Treatment of patent ductus arteriosus: indomethacin or ibuprofen?

Sekar, Krishnamurthy; Corff, Karen E.

doi:10.1038/jp.2008.52

Cited by 56 publications

(48 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17 Indomethacin reduces the blood flow velocity in kidneys, intestine, and brain, ibuprofen has not this effect. 1,14 In infants who received 2 or more courses, the decrease in urine output and the increase in serum creatinine concentration were not different between ibuprofen and indomethacin.…”

Section: ■ Discussionmentioning

confidence: 98%

“…Chan et al 10 compared of therapy: an early onset of treatment increases the chances of success. 1 At the time of writing, ibuprofen is becoming the first choice for ductal closure due to its higher association with cerebral, gastrointestinal and renal blood flow velocity, whereas ibuprofen does not exhibit this effect. 2 Renal failure is more common in infants receiving indomethacin compared to ibuprofen.…”

Section: Indomethacin Vs Ibuprofen By Intravenous Administrationmentioning

confidence: 99%

“…3 Surgical treatment is the only option when pharmacological treatment fails to close the PDA in symptomatic infants. 1 As noted, ibuprofen and indomethacin are potent non-selective cyclo-oxygenase (COX) inhibitors and therefore block the conversion of arachidonic acid to prostaglandins.…”

Section: Indomethacin Vs Ibuprofen By Intravenous Administrationmentioning

confidence: 99%

See 2 more Smart Citations

Ibuprofen and indomethacin for the closure of the patent ductus arteriosus

Pacifici¹

2016

Medical Express

View full text Add to dashboard Cite

The ductus arteriosus connects the pulmonary artery with the aorta and allows right ventricular blood to bypass the unexpanded lungs. In mature infants, the ductus arteriosus closes after birth. Patent ductus arteriosus occurs in 70% of preterm infants with a birth weight < 1,000 grams. Failure of the ductus arteriosus to close has been associated with intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, periventricular leukomalacia, renal failure, and persistent pulmonary hypertension. The drugs used to treat the patent ductus arteriosus are ibuprofen and indomethacin which are potent non-selective inhibitors of cyclo-oxygenase (COX) and therefore inhibit prostaglandin E2 synthesis. Prostaglandin E2 relaxes smooth muscle and tends to inhibit the closure of the patent ductus arteriosus. Intravenous ibuprofen and indomethacin inhibit prostaglandin E2 synthesis and thereby close the patent ductus arteriosus with similar efficacy. Indomethacin reduces the blood flow velocity in kidneys, intestine and brain. Ibuprofen has less effect on blood flow velocity in these organs. There is a significant increase in serum creatinine after indomethacin administration but not after ibuprofen and infants treated with ibuprofen have higher creatinine clearance. Oliguria (urine output < 1 ml/kg/h) occurs more frequently with indomethacin than with ibuprofen. Indomethacin requires furosemide for urine output more often than ibuprofen. Ibuprofen reduces the risk of necrotizing enterocolitis and transient renal insufficiency and it is the drug of choice for closing the patent ductus arteriosus. Ibuprofen and indomethacin may be administered orally. In conclusion, intravenous ibuprofen and indomethacin close the patent ductus arteriosus at the same rate, but indomethacin is more toxic than ibuprofen.

show abstract

Section: ■ Discussionmentioning

confidence: 98%

Section: Indomethacin Vs Ibuprofen By Intravenous Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Ibuprofen and indomethacin for the closure of the patent ductus arteriosus

Pacifici¹

2016

Medical Express

View full text Add to dashboard Cite

show abstract

“…[3] The success of treatment with intravenous medication has been questionable in some cases. [3] Thus, over the last three decades, several techniques of catheterization closure have been described. [4] The success rate is significantly higher for PDA if it has a diameter smaller than 2.5 mm.…”

Section: Discussionmentioning

confidence: 99%

A rare complication of patent ductus arteriosus coil occlusion involving a foreign body migrating rapidly from the femoral vein to the right ventricle

Talay¹

2013

Turk Gogus Kalp Dama

View full text Add to dashboard Cite

“…5 Penutupan DA secara spontan hanya terjadi pada 34% BKB. 6,7 Penutupan spontan DAP tanpa sindrom gawat nafas pada BKB sebesar 10% pada hari ke-1, 60% hari ke-2, 85 % hari ke-3 dan 97% hari ke-4. Apabila penutupan spontan tidak terjadi pada hari ke-4 maka akan menjadi duktus arteriosus persisten.…”

unclassified

Perbandingan Efektifitas dan Keamanan Parasetamol Intravena dan Ibuprofen Oral pada Penutupan Duktus Arteriosus Persisten pada Bayi Kurang Bulan

Sari

Nova

Bermawi

et al. 2016

View full text Add to dashboard Cite

Latar belakang. Duktus arteriosus persisten (DAP) pada bayi kurang bulan (BKB) dapat menimbulkan gangguan hemodinamika sehingga perlu segera ditutup. Salah satu cara penutupan adalah dengan obat penghambat siklooksigenase (COX), khususnya ibuprofen. Mengingat efek samping yang ditimbulkan ibuprofen, parasetamol yang bekerja menghambat peroksidase mulai diperkenalkan sebagai alternatif dengan efektifitas setara dan efek samping yang minimal. Tujuan. Membandingkan efektifitas dan keamanan antara parasetamol intravena dan ibuprofen oral untuk penutupan DAP pada BKB. Metode. Uji klinis terbuka, acak terkontrol pada bayi dengan usia gestasi ≤37 minggu yang dikonfirmasi DAP dengan menggunakan ekokardiografi. Dilakukan randomisasi blok untuk menerima parasetamol intravena atau ibuprofen oral. Hasil utama yang dinilai adalah respon terapi penutupan duktus arteriosus (DA), efek samping yang timbul, dan kejadian reopening. Hasil. Penutupan DAP terjadi pada 33 dari 36 (91,6%) BKB yang mendapat parasetamol intravena dan 29 dari 40 (72,5%) yang mendapat ibuprofen oral (p=0,03). Pada kelompok ibuprofen, efek samping yang timbul berupa trombositopenia (28,5%) dan perdarahan saluran cerna (25,7%), sedangkan pada kelompok parasetamol intravena tidak dijumpai efek samping. Reopening terjadi hanya pada satu bayi di kelompok ibuprofen oral. Kesimpulan. Parasetamol intravena lebih efektif dan lebih aman dibandingkan ibuprofen oral untuk penutupan DAP pada BKB. Sari Pediatri 2015;17(4):279-84. Kata kunci: duktus arteriosus persisten, bayi kurang bulan, parasetamol intravena, ibuprofen oral The Comparison of Effectiveness and Safety between Intravenous Paracetamol and Oral Ibuprofen for Persistent Ductus Arteriosus in Preterm InfantsOktaviliana Sari,* Ria Nova,* Herman Bermawi,* Erial Bahar** Background. Persistent ductus arteriosus (PDA) in preterm infants can cause hemodynamic disturbances, that it must be closed immediately. PDA can be closed using cyclooxygenase inhibitor agents (COX), mainly ibuprofen. Because the side effects, intravenous paracetamol, a peroxidase inhibitor was recently introduced as an alternative terapy for ductal closure with similar effectiveness and minimal side effects. Objectives. To compare the effectiveness and safety of intravenous paracetamol and oral ibuprofen for PDA closure in preterm infants.Methods. An open label randomized controlled study was done in seventy six preterm infants (gestational age ≤37 weeks) with echocardiographically confirmed PDA. Infant were randomly assigned to received either intravenous paracetamol or oral ibuprofen. The main outcome was the success of ductal closure and secondary outcomes were adverse effects and reopening. Results. PDA closure was achieved in 33 of 36 (91.6%) infants receiving intravenous paracetamol and in 29 of 40 (72.5%) infants receiving oral ibuprofen (p=0.03). In the ibuprofen group, thrombocytopenia and gastrointestinal bleeding were found in 28.5% and 25.7% infants respectively, while in the paracetamol group, no adverse effect was observed. There ...

show abstract

Treatment of patent ductus arteriosus: indomethacin or ibuprofen?

Cited by 56 publications

References 27 publications

Ibuprofen and indomethacin for the closure of the patent ductus arteriosus

Ibuprofen and indomethacin for the closure of the patent ductus arteriosus

A rare complication of patent ductus arteriosus coil occlusion involving a foreign body migrating rapidly from the femoral vein to the right ventricle

Perbandingan Efektifitas dan Keamanan Parasetamol Intravena dan Ibuprofen Oral pada Penutupan Duktus Arteriosus Persisten pada Bayi Kurang Bulan

Contact Info

Product

Resources

About