Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity

Abstract

With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization and rehydration and systemic corticosteroids if necessary, the prognosis is good.

Efficacy and safety of currently marketed anti-osteoporosis medications

“…This incidence is in the vicinity of what has been previously reported as severe skin reactions with most other currently available anti-OP medications [130]. A causative link has not been firmly established, as strontium is a trace element naturally present in the human body and ranelic acid is poorly absorbed.…”

Antifracture Efficacy of Currently Available Therapies for Postmenopausal Osteoporosis

“…While the osteoporosis treatments are generally considered safe, they have been associated with some rare adverse reactions. [56,57] Even mild adverse reactions can constitute considerable barriers to adherence and persistence, and should therefore be carefully assessed with modification of mode of drug administration, dosing regimen and cost if necessary. [1,23] On the other hand, rare adverse reactions to osteoporosis treatments should never be considered as a reason not to treat a woman at risk of fracture.…”

Ranélate de strontium (Protelos®) : effets indésirables rapportés en France

“…Leurs caractéristiques sont conformes à celles des DRESS dus à d'autres médicaments. En dehors des deux premiers cas français publiés par notre équipe [11], plus d'une dizaine de cas ont été publiés [12][13][14], certains insistant sur une atteinte systémique particulière hépatique [15] ou rénale [12,16]. L'incidence des cas spontanément notifiés en France (1/ 13 725 nouveaux patients) est difficile à comparer à celles des DRESS notifiés avec les médicaments le plus souvent mis en cause (allopurinol, minocycline, sulfonamides, antiépilep-tiques, anti-VIH) [17] car les méthodes de recueil sont différentes et que nos données sont des valeurs minimum puisqu'elles sont basées sur la notification spontanée.…”