Treatment of osteoporosis in men

Kaufman, JM; Reginster, JY; Boonen, Steven; Brandi, Maria Luisa; Cooper, Cyrus; Dere, Willard H.; Devogelaer, J.-P.; Díez-Pérez, Adolfo; Kanis, John А.; McCloskey, Eugène; Mitlak, Bruce; Orwoll, Eric; Ringe, J. D.; Weryha, G.; Rizzoli, René

doi:10.1016/j.bone.2012.11.018

Cited by 87 publications

(54 citation statements)

References 103 publications

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“…They are considered to be the first choice for treating osteoporosis and should be used together with calcium and vitamin supplements. 18,19 A recent review failed to find any systematic reviews or metaanalyses of studies with three-year or longer follow-ups assessing fractures as outcomes associated with use of bisphosphonates.…”

Section: Discussionmentioning

confidence: 99%

Cross-cultural adaptation and content validation of START

Luz¹,

Oliveira

Noblat

2016

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: Non-treatment of diseases or clinical conditions has been considered to constitute omission of care in several countries. The aim of the present study was to develop a transcultural adaptation of the Screening Tool to Alert Doctors to the Right Treatment (START) to Brazilian Portuguese and to validate the tool's content. DESIGN AND SETTING: Cultural adaptation and validation of the START criteria using the Delphi consensus technique. METHOD: START was translated from its original language into Brazilian Portuguese, followed by backtranslation and validation by means of the modified Delphi technique. For this, an electronic form was developed and sent to 20 experts, who were asked to use a Likert scale to assess the statements included in START, in relation to their pertinence to Brazilian realities. All of the statements that exhibited mean scores greater than 4.0 were considered to have attained consensus. The experts' identities were kept confidential throughout the validation process. RESULTS:In the first phase of the validation process, 63.6% (14/22) of the statements in START attained consensus. The remaining statements were returned to the experts so that they could have the opportunity to review their comments and statements and to assess them again, based on the Likert scale used earlier. In this phase, 100% of the START instrument attained consensus. CONCLUSION: The content of START was entirely validated for Brazil, with all of the original criteria maintained.RESUMO CONTEXTO E OBJETIVO: O não tratamento de doenças ou condições clínicas tem sido apontado como omissão no cuidado em diversos países. O objetivo deste estudo foi realizar a adaptação transcultural para o português brasileiro e sua validação de conteúdo do questionário START (Screening Tool to Alert Doctors to the Right Treatment). TIPO DE ESTUDO E LOCAL:Adaptação cultural e validação dos critérios START através da técnica de consenso Delphi. MÉTODO: O START foi submetido à tradução da língua original para o Português (Brasil), tradução reversa e validação de conteúdo por meio da técnica Delphi modificada. Para isso, um formulário eletrônico foi desenvolvido e enviado a 20 especialistas para o julgamento das proposições presentes na ferramenta START conforme sua pertinência para a realidade brasileira, utilizando uma escala de Likert. Foram consideradas consensuais todas as proposições que apresentaram média superior a 4,0. A identificação de cada especialista foi mantida em confidencialidade durante o todo o processo. RESULTADOS: Na primeira fase da validação, foi obtido consenso em 63,6% (14/22) das proposições contidas na ferramenta START. As proposições não consensuais foram reencaminhadas para os especialistas, que tiveram a oportunidade de rever seus comentários e proposições e julgá-las com base na escala de Likert utilizada previamente. Nessa fase, foi obtido consenso em 100% do instrumento START. CONCLUSÃO: O conteúdo do START foi validado para o Brasil na sua totalidade, com todos os critérios origina...

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Section: Discussionmentioning

confidence: 99%

Cross-cultural adaptation and content validation of START

Luz¹,

Oliveira

Noblat

2016

Sao Paulo Med. J.

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“…9 It affects not only women but also men, a frequently under-recognized fact. 10,11 Osteoporotic fractures in men, although less frequent than in women, are associated with a higher mortality. 12,13 Following the diagnosis of an osteoporotic fracture, in addition to clinical evaluation and risk factors assessment (e.g.…”

Section: Causes Of Bone Loss In Menmentioning

confidence: 99%

“…In men, 50% of cases are secondary to one of three conditions: endogenous or exogenous glucocorticoid excess, hypogonadism, and excessive alcohol consumption. 10,11 In addition to these, idiopathic hypercalciuria-defined as urinary calcium > 3-4 mg/kg/day or 300 mg/24 h-is present in 8% of men with osteoporosis.…”

Section: Causes Of Bone Loss In Menmentioning

confidence: 99%

“…[10][11][12][13][14] OSA, another chronic respiratory disorder, is not a known cause of osteoporosis, but could lead to bone loss and increased risk of fracture through multiple mechanisms, including hypogonadism, sympathetic activation, systemic inflammation, oxidative stress, hypercortisolism, and hypoxemia, as discussed next.…”

Section: Potential Causes Of Bone Loss In Men With Osamentioning

confidence: 99%

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Bone Loss in Obesity and Obstructive Sleep Apnea: A Review of Literature

Chakhtoura

Nasrallah

Chami

2015

Journal of Clinical Sleep Medicine

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“…Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors [9]. Osteoporosis is a progressive skeletal disorder, due to the unequal coupling between osteoclast mediated bone resorption and osteoblast mediated bone formation [10,11]. Anti-osteoporotic effects of the newly synthesized coumarine pyridine hybrids were evaluated in primary cultures of rat calvarial osteoblasts in vitro [12].…”

Section: Introductionmentioning

confidence: 99%

Succinimide-N-sulfonic acid as an efficient recyclable catalyst for the synthesis of some fused indolo pyrano pyrimidinone derivatives

Mansoor¹,

Logaiya²,

Sudhan³

et al. 2015

Bull. Chem. Soc. Eth.

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ABSTRACT.A new, simple, thermally efficient and solvent-free condensation of 2-amino-4,5-dihydro-4-phenylpyrano[3,2-b]indole-3-carbonitrile derivatives with coumarin-3-carboxylic acid employing succinimide-Nsulfonic acid (SuSA) as catalyst for the synthesis of a series of 5,6-dihydro-2-(2-oxo-2H-chromen-3-yl)-5-phenylindolo[2',3':5,6]pyrano[2,3-d]pyrimidin-4(3H)-one derivatives is described. This method has the advantages of high yield, simple methodology, and short reaction time, as well as being green in terms of avoiding the use of toxic catalysts and solvents. Furthermore, the catalyst could be recycled and reused four times without significant loss of activity. Thiourea dioxide (TUD) catalyzed efficient three-component coupling reactions of aromatic aldehydes, 3-hydroxyindole and malononitrile in water at 70 ºC was described as the preparation of 2-amino-4,5-dihydro-4-phenylpyrano[3,2-b]indole-3-carbonitrile derivatives.

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Treatment of osteoporosis in men

Cited by 87 publications

References 103 publications

Cross-cultural adaptation and content validation of START

Cross-cultural adaptation and content validation of START

Bone Loss in Obesity and Obstructive Sleep Apnea: A Review of Literature

Succinimide-N-sulfonic acid as an efficient recyclable catalyst for the synthesis of some fused indolo pyrano pyrimidinone derivatives

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