Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin

Xie, Zongping; Liu, Xin; Jia, Weitao; Zhang, Changqing; Huang, Wenhai; Wang, Jianqiang

doi:10.1016/j.jconrel.2009.06.012

Cited by 138 publications

(114 citation statements)

References 32 publications

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“…After being loaded with drug, the borate bioactive glass therefore served as a multifunctional device, initially providing a local drug release function and later serving as a scaffold for bone repair. At the same time, it can maintain its high compressive strength after immersion in SBF, as proved by our previous investigations (7,13). It could also be used at a location where load bearing is required.…”

Section: Discussionmentioning

confidence: 52%

“…A limitation of TCP is that it degrades too slowly to match the bone regeneration rate (6). Calcium sulfate also has disadvantages, such as a transient cytotoxic effect, leading to inflammatory reactions, insufficient ability to stimulate bone regeneration, a high resorption rate, quick elution in vitro, friability, and low mechanical strength (7).…”

mentioning

confidence: 99%

“…Our previous studies have shown that borate glass as a carrier of vancomycin or teicoplanin is successful at eradicating osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA) in a rabbit model, showing excellent biocompatibility and compressive strength, supporting full osteointegration with direct apposition of the newly formed bone, and stimulating bone regeneration as it degrades (7,13).…”

mentioning

confidence: 99%

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Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model

Xie

Cui

Zhao

et al. 2013

Antimicrob Agents Chemother

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The treatment of osteomyelitis induced by Gram-negative bacilli is rarely reported in the literature. This study established a rabbit tibia model of osteomyelitis induced by the Gram-negative bacillus Escherichia coli. Using this model, pellets composed of a chitosan-bonded mixture of borate bioactive glass and gentamicin were evaluated in vitro and in vivo for the treatment of osteomyelitis induced by Escherichia coli. Our results showed that the pellets in phosphate-buffered saline released gentamicin continuously over 26 days. Without the simultaneous use of a systemic antibiotic, the implantation of the gentamicin-loaded pellets into the osteomyelitis region of the tibia resulted in the eradication of 81.82% of infections, as determined by microbiological, histological and radiographic evaluation, and supported the ingrowth of new bone into the tibia defects after 6 weeks of implantation. The results indicate that the gentamicin-loaded borate bioactive glass implant, combining sustained drug release with the ability to support new bone formation, could provide a method for treating osteomyelitis induced by Gram-negative bacilli.

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Section: Discussionmentioning

confidence: 52%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model

Xie

Cui

Zhao

et al. 2013

Antimicrob Agents Chemother

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“…Subsequently, the vancomycin loaded bioglass pellets were used in a rabbit tibial infection model. After 11 weeks, 81.25% of the animals showed no signs of infection along with good bone growth and osseointegration [21]. In another study, borate bioglass was mixed with chitosan to form a injectable paste, which was subsequently loaded with vancomycin.…”

Section: Bioactive Glassmentioning

confidence: 99%

Novel Local Bone Void Filling Antibiotic Carriers for the Treatment of Bone Infection

Brooks¹

2017

OPROJ

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“…37 Among current pharmaceuticals, the classical antibiotic vancomycin has been widely used in the therapeutic treatment for osteomyelitis. 38 However, some drawbacks exist in the traditional therapy (such as injections and oral administration).…”

mentioning

confidence: 99%

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

Pan

et al. 2017

IJN

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Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting–particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.

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Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin

Cited by 138 publications

References 32 publications

Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model

Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model

Novel Local Bone Void Filling Antibiotic Carriers for the Treatment of Bone Infection

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

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