Treatment of oral cancers during pregnancy: a case-based discussion

Satô, Kiyoshi; Shiba, Hiroaki; Mochizuki, Yumi; Hirai, Hideaki; Tomioka, Hirofumi; Shimizu, Ryo; Marukawa, Eriko; Fukayama, Haruhisa; Yoshimura, Ryoichi; Ishida, Hiroo; Harada, Hiroyuki

doi:10.1186/s40463-019-0331-1

Cited by 16 publications

(16 citation statements)

References 36 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 7 The tongue is a common organ, which has a great influence on fasting, drinking water, and speaking. 8 There is therefore an urgent need to find more targets for the treatment of tongue cancer, as well as to develop more effective drugs and treatment methods. The analysis and summary of gene data is therefore the fastest and most effective way to identify effective targets.…”

Section: Introductionmentioning

confidence: 99%

Silencing of SPP1 Suppresses Progression of Tongue Cancer by Mediating the PI3K/Akt Signaling Pathway

Zhang

Lai

et al. 2020

Technol Cancer Res Treat

View full text Add to dashboard Cite

Background: In the present study, we aimed to find an effective target for the treatment of tongue cancer using gene chip screening and signal pathway research. Methods: We used microarray screening and gene expression profile analyses to find important differentially expressed genes in tongue cancer. We constructed a protein-protein interaction network, and used enrichment analysis of the Kyoto Encyclopedia of Genes and Genomes to screen for important genes. We then silenced the genes of interest in SCC154 cells to study the relationship with the Phosphatidylinositol 3-kinase/Akt signal pathway. Western blot analyses, the 3-(4,5Dimethylthiazol-yl)-2,5Dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) test, and immunofluorescence assays were used to compare the expression levels of Phosphatidylinositol 3-kinase/Akt signal pathway-related proteins, cell viability, and cell proliferation ability in normal SCC154 cells, Si-RNA SCC154 cells, and gene-silenced SCC154 cells. The scratch test, Transwell test, and western blotting were used to determine migration, invasion, and carcinogenesis. Results: Using GSE9844, GSE13601, and GSE31056 gene chips, we identified 93 upregulated genes and 76 downregulated genes in tongue cancer. Using the protein-protein interaction network and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we further identified 47 differentially expressed genes. Using Kaplan-Meier plotter online tools, we also identified 3 genes (SPP1, Recombinant Human Secreted Phosphoprotein 1; PLAU, plasminogen activator urinary; and APP, amyloid precursor protein). Compared with normal SCC154 cells and Si-RNA control SCC154 cells, the expressions of Phosphatidylinositol 3-kinase/Akt pathway proteins in si-SPP1 SCC154 cells were significantly decreased (*P < 0.05), and the protein activities and proliferation abilities were also significantly decreased (*P < 0.05), while the migration ability, invasion ability, and cancer forming ability were significantly increased (*P < 0.05). Conclusion: Inhibition of the SPP1 gene may have a therapeutic effect on tongue cancer, and could be an effective target for the treatment of this disorder.

show abstract

Section: Introductionmentioning

confidence: 99%

Silencing of SPP1 Suppresses Progression of Tongue Cancer by Mediating the PI3K/Akt Signaling Pathway

Zhang

Lai

et al. 2020

Technol Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…One in 118 pregnant women in the early stages of cancer is pregnant [1,2]. The most common cancers during pregnancy are those with the highest impact during the reproductive period such as breast and cervical neoplasms, hematological malignancies, cancers of the colon, ovarian and melanoma [3,4]. The most commonly reported rates of cancer during pregnancy are breast cancer in a percentage of 46%, hematological cancers in a percentage of 18% and oral cancers with a frequency of less than 2% [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…The most common cancers during pregnancy are those with the highest impact during the reproductive period such as breast and cervical neoplasms, hematological malignancies, cancers of the colon, ovarian and melanoma [3,4]. The most commonly reported rates of cancer during pregnancy are breast cancer in a percentage of 46%, hematological cancers in a percentage of 18% and oral cancers with a frequency of less than 2% [3,4]. In particular, cancers of the oral cavity during pregnancy include cancer of the larynx, thyroid, melanoma and lymphoma with a frequency twice as high in men as in women.…”

Section: Introductionmentioning

confidence: 99%

Tongue cancer and Pregnancy: Report of two cases in association with HPV infection and literature review. Is HPV vaccination necessary to prevent of tongue cancer?

Tsikouras¹,

Paraskevopoulos²,

Bothou³

et al. 2020

J Syst Integr Neurosci

View full text Add to dashboard Cite

The detailed research for more information on the very important area of tongue cancer is the purpose of the present study. We report two cases of pregnant women suffering from tongue cancer during pregnancy, the treatment of tongue cancer and information on the outcome of pregnancy. Pregnancy should not be considered an obstacle to the proper treatment of a mother's tongue malignancy. The epidemiological trend in recent years is to increase the overall survival of patients and keep them free of disease for a longer period of time. The reported pregnant women were in the third trimester of pregnancy with tongue cancer symptoms at 37 and 32 weeks, respectively. After detailed information, the cesarean section was performed and the two women treated according to the proposed protocols which were as following: surgical removal of tumors, lymph node dissection in 5 levels and postoperative radiotherapy. The first case of these recurred 3 months later, underwent surgical removal of the tumor and subsequently underwent chemotherapy and immunotherapy. She died one year after the primary diagnosis of tongue cancer. The perinatal effect was perfect in both cases. The lack of systematic randomized prospective studies and the difficulties in carrying them out in general, make bibliographic review even more useful in guidelines, retrospective studies, series of events and individual cases for future scientific studies to be performed in order to establish treatment protocols.

show abstract

“…For many years, health professionals were unsure about how to deal with this cancer especially during pregnancy. Most women with cancer start or continue treatment during pregnancy so there is more medical information and information about the treatment and course of cancer in pregnant women [4][5][6]. Cancer during pregnancy can be complicated for both the mother and for the medical staff that has undertaken the treatment and monitoring of her pregnancy.…”

Section: Introductionmentioning

confidence: 99%

HPV induced tongue cancer in pregnancy: Diagnosis and the role of vaccination in management

Tsikouras¹,

Bothou²,

Paraskevopoulos³

et al. 2020

Clin Obstet Gynecol Reprod Med

View full text Add to dashboard Cite

Oral cancer is frequently a squamous cell carcinoma. In Western countries it is more commonly found on the tongue and consists one of the most common malignancies in the oral mucosa. The exact causes of squamous cell carcinoma are not known. There are many risk factors such as chemical, biological, natural and other related to culture, habits, customs and traditions, religion and environmental influences at the national level and differ in different nations. Biological agents are viruses (such as the herpes simplex virus, HPV, HIV) and mycoses. Human papillomavirus (HPV), especially HPV subtype 16, is on the rise in young people with oral cancer who are not smokers. Epidemiological studies throughout world with the help of molecular techniques undoubtedly show the crucial importance of human papillomavirus (HPV) in growth squamous cell carcinoma. The sensitive anatomical unit of the tongue in cases of malignancy in pregnant women creates significant bioethical concerns that must be addressed with delicacy, discernment and responsibility by the oncology medical team. The contribution of the 9 valent vaccination, which provides protection against this oncogenic subtype of HPV 16 associated with squamous cell carcinoma, is likely to be valuable to young women and men, and may be recommended after future studies during pregnancy.

show abstract

Treatment of oral cancers during pregnancy: a case-based discussion

Cited by 16 publications

References 36 publications

Silencing of SPP1 Suppresses Progression of Tongue Cancer by Mediating the PI3K/Akt Signaling Pathway

Silencing of SPP1 Suppresses Progression of Tongue Cancer by Mediating the PI3K/Akt Signaling Pathway

Tongue cancer and Pregnancy: Report of two cases in association with HPV infection and literature review. Is HPV vaccination necessary to prevent of tongue cancer?

HPV induced tongue cancer in pregnancy: Diagnosis and the role of vaccination in management

Contact Info

Product

Resources

About