Tongue cancer and Pregnancy: Report of two cases in association with HPV infection and literature review. Is HPV vaccination necessary to prevent of tongue cancer?

Abstract

The detailed research for more information on the very important area of tongue cancer is the purpose of the present study. We report two cases of pregnant women suffering from tongue cancer during pregnancy, the treatment of tongue cancer and information on the outcome of pregnancy. Pregnancy should not be considered an obstacle to the proper treatment of a mother's tongue malignancy. The epidemiological trend in recent years is to increase the overall survival of patients and keep them free of disease for a longer period of time. The reported pregnant women were in the third trimester of pregnancy with tongue cancer symptoms at 37 and 32 weeks, respectively. After detailed information, the cesarean section was performed and the two women treated according to the proposed protocols which were as following: surgical removal of tumors, lymph node dissection in 5 levels and postoperative radiotherapy. The first case of these recurred 3 months later, underwent surgical removal of the tumor and subsequently underwent chemotherapy and immunotherapy. She died one year after the primary diagnosis of tongue cancer. The perinatal effect was perfect in both cases. The lack of systematic randomized prospective studies and the difficulties in carrying them out in general, make bibliographic review even more useful in guidelines, retrospective studies, series of events and individual cases for future scientific studies to be performed in order to establish treatment protocols.

Follow-Up of Tongue Cancer Diagnosed During Pregnancy: A Case Report

“…Despite its common age, oral cancer can also be seen in reproductive age [8]. In the history of these people, tobacco and cigarette consumption, alcohol abuse, and having a history of cancer in the first degree family members are usually seen [1,8].…”

“…Despite its common age, oral cancer can also be seen in reproductive age [8]. In the history of these people, tobacco and cigarette consumption, alcohol abuse, and having a history of cancer in the first degree family members are usually seen [1,8]. Due to the rarity of tongue cancer during pregnancy, it is possible to diagnose this disease with a low level of clinical suspicion, misdiagnosis and delay in treatment.…”

“…On the other hand, due to the rarity of this type of cancer during pregnancy, the treatment methods, prognosis and long-term effect on fetal growth are not well known [9]. Unfortunately, until now, there are no international guidelines available for the treatment of oral tongue cancer during pregnancy [10][11][12].…”