Treatment of Ocular Surface Squamous Neoplasia With Topical Aloe vera Drops

Abstract

Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.

Diagnosis and medical management of ocular surface squamous neoplasia

“…The three most studied and used compounds are interferon-α2b (IFN-α2b),[23–28] 5-fluorouracil,[29–32] and mitomycin C (MMC). [33–40] (Table 2) Anti-vascular endothelial growth factor (anti-VEGF),[41–45] retinoic acid,[46,47] and aloe vera[48] have also been used but their efficacy is not well-established yet.…”

“…The use of aloe vera in the form of eye drops has been reported in one case,[48] with resolution after 3 months of continuous use 3 times per day. However, the lesion was not biopsy-proven OSSN at diagnosis due to patient refusal.…”

Update on pharmacotherapy for ocular surface squamous neoplasia

“…Aloe plants demonstrate antiproliferative, immunostimulatory and antioxidant properties. Aloe consists of the molecules aloin and aloe emodin which mediate the anti-proliferative activity [111, 112]. Studies have shown that aloe emodin can induce apoptosis in vitro [112].…”

“…Aloe consists of the molecules aloin and aloe emodin which mediate the anti-proliferative activity [111, 112]. Studies have shown that aloe emodin can induce apoptosis in vitro [112]. Acemannan is a D-isomer mucopolysaccharide in Aloe vera with immunostimulatory effects, likely inducing an anti-neoplastic outcome [111, 112] .…”

“…Studies have shown that aloe emodin can induce apoptosis in vitro [112]. Acemannan is a D-isomer mucopolysaccharide in Aloe vera with immunostimulatory effects, likely inducing an anti-neoplastic outcome [111, 112] .…”