Treatment of nine cases of pemphigus vulgaris with cyclosporine

Barthélémy, H; Frappaz, A.; Cambazard, F.; Mauduit, G; Rouchouse, B.; Kanitakis, Jean; Souteyrand, P.; Claudy, A; Thivolet, J

doi:10.1016/s0190-9622(88)70132-2

Cited by 85 publications

(30 citation statements)

References 6 publications

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“…Cyclosporine A Inhibits mitochondrial permeability transition pore by preventing the binding of cyclophilin D to pore proteins (42,43) Used to treat PV patients as an immunosuppressor drug both systemically and topically; has been effective as a monotherapy in a few PV patients, but most commonly used as a steroid-sparing drug, inducing a prolong remission (29)(30)(31)(44)(45)(46)(47); partially inhibited signs of experimental PV in mice (48) Nicotinamide, also called niacinamide, an amide of nicotinic acid; one of two principal forms of the B-complex vitamin, B 3 Nicotinamide is a precursor of the coenzyme NAD …”

Section: Treatment Of Pv Patientsmentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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Background: Previous studies suggested that mitochondrial antibodies contribute to pemphigus vulgaris (PV). Results: PV sera elicited mitochondrial damage, and mitochondria-protecting drugs exhibited protective effect in cell culture and mouse skin. Conclusion: PV antibodies altered O 2 respiration, disrupted electron transfer chain, and increased reactive oxygen species. Significance: Results provide the mechanism of therapeutic action and justify the use of mitochondria-protecting drugs in PV.

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Section: Treatment Of Pv Patientsmentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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“…[6][7][8][9] To decrease the exposure to corticosteroids, the use of steroid-sparing agents in pemphigus has become common. These agents include azathioprine, 3 cyclosporine, 10,11 gold, 12 dapsone, 13 antimalarials, 14 and cyclophosphamide. 2 However, these treatment modalities may cause adverse reactions of their own.…”

mentioning

confidence: 99%

Pulse Intravenous Cyclophosphamide Therapy in Pemphigus

Fleischli¹,

Valek²,

Pandya³

1999

Arch Dermatol

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“…Immunoablative high-dose cyclophosphamide without stem cell rescue has been successful in one patient (Hayag et al, 2000). Cyclosporin has proved effective in some hands (Balda and Rosenzweig, 1986;Cunliffe, 1987;Barthelemy et al, 1988;Mobini et al, 1997b) but not in others as an adjuvant to corticosteroids (Ioannides et al, 2000). However, methotrexate is not recommended (Carson et al, 1996).…”

Section: Alternative Treatments To Corticosteroidsmentioning

confidence: 99%

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

Scully

Challacombe

2002

Critical Reviews in Oral Biology & Medicine

136

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ABSTRACT:Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Certain ethnic groups, such as Ashkenazi Jews and those of Mediterranean origin, are especially liable to pemphigus. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examinations, is essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected by both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay (ELISA). Before the introduction of corticosteroids, pemphigus vulgaris was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids, with azathioprine, dapsone, methotrexate, cyclophosphamide, and gold as adjuvants or alternatives, but mycophenolate mofetil and intravenous immunoglobulins also appear promising.

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Treatment of nine cases of pemphigus vulgaris with cyclosporine

Cited by 85 publications

References 6 publications

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Pulse Intravenous Cyclophosphamide Therapy in Pemphigus

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

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