Pulse Intravenous Cyclophosphamide Therapy in Pemphigus

Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris

“…18,25 The use of pulsed intravenous cyclophosphamide decreases the adverse effects associated with oral administration, especially with respect to malignancies such as bladder cancer. [26][27][28] In our study, P/PC induced remission in 73.3% of patients after 1 year of treatment.…”

Management of autoimmune bullous diseases: Pharmacology and therapeutics

“…28 A recent uncontrolled study by Fleischli et al reported 7 patients with severe or recalcitrant PV who underwent treatment with pulse cyclophosphamide (starting monthly dose of 0.5 to 1.0 g/m 2 of body surface area and increased by 100 to 250 mg per dose, provided the white blood cell count is acceptable) along with oral prednisone and 50 mg of cyclophosphamide daily. 30 Four of the patients had an excellent response, which allowed a decrease in their prednisone dose. More recently, Hayag et al reported the successful use of immunoablative, high-dose cyclophosphamide without stem cell rescue (50 mg/kg intravenous cyclophosphamide for 4 days) in a patient with severe and refractory PV.…”

Minimizing Complications in Autoimmune Blistering Diseases

“…Hyperpigmentation of the skin, mucous membranes, and nails has been reported with the use of cyclophosphamide. [16][17][18][19] IVIG is prepared from pooled plasma and may contain some IgA. Anaphylaxis may occur in IgAdeficient patients, therefore it is recommended to measure IgA levels before initiating IVIG.…”