Minimizing Complications in Autoimmune Blistering Diseases

Clay, Tiffany; Pandya, Amit G.

doi:10.1016/j.det.2011.06.005

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…Studies showed that AIBD treatment can impact the quality of life as much as disease itself. 4 , 5 , 7 In this study, TABQOL scores of PV, BP, and all patients were lower than TABQOL scores reported in Australia, 9 China, 11 Poland, 7 Turkey, 12 and Egypt 13 ; while PF patients in our study had higher TABQOL scores than previously reported studies, probably due to cultural differences or treatment approach. Compared with our population, Australian and Turkish 9 , 12 studies demonstrated the highest TABQOL among EBA patients; also, in the Egyptian study, 13 EBA was reported to have the second-highest TABQOL score.…”

Section: Discussioncontrasting

confidence: 79%

“…Other noncorticosteroid drugs have reduced dependency on corticosteroids, but they have complications of their own such as headache, lethargy, fever, myalgia, gastrointestinal symptoms, hepatotoxicity, bone marrow suppression, and immunosuppression. 5 …”

Section: Introductionmentioning

confidence: 99%

“…In this regard, assessing AIBD patients’ quality of life related to treatment using TABQOL is of great importance. 4 , 5 In this study, we have measured AIBD patients’ quality of life using the Farsi TABQOL questionnaire.…”

Section: Introductionmentioning

confidence: 99%

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Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Behkar

Garmaroudi

Nasimi

et al. 2022

International Journal of Women’s Dermatology

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Background: In autoimmune bullous diseases (AIBDs), autoantibodies loosen molecular adhesions in the skin and/or mucosa and lead to blisters and erosions. Immunosuppressive drugs reduce mortality of the AIBD; therefore, patients will have to live longer with comorbidities. Objective: This study aims to determine the quality of life of AIBD patients undergoing systemic treatment while investigating the survey’s relationship with various factors. Methods: In this 2-step cross-sectional study, we initially included 53 consecutive pemphigus patients to investigate reliability and validity of the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life (TABQOL) questionnaire. Then, we conducted the study on 119 AIBD patients, currently under treatment at an AIBD clinic in Iran. Results: The mean TABQOL score for our patients was 13.87 ± 7.51. The highest TABQOL was for epidermolysis bullosa acquisita (24 ± 8.485) followed by pemphigus foliaceus (20.5 ± 14.181) and the lowest for pemphigus vulgaris (13.24 ± 6.54). There was no significant difference between patients’ TABQOL scores and their gender, history of rituximab injection, and disease severity scores. We only found a positive correlation between TABQOL and prednisolone dose. Conclusion: Treatments of AIBD considerably impact the quality of life of patients and an impairment in quality of life is correlated to higher doses of prednisolone.

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Section: Discussioncontrasting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Behkar

Garmaroudi

Nasimi

et al. 2022

International Journal of Women’s Dermatology

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“…Various treatment modalities such as blockage of T cell receptor (TCR) signaling pathways, intervention of costimulatory and accessory molecules, T cell depletion, alteration of T cell adhesion and trafficking as well as modulation of cytokines have been designed and clinically applied for treatment of autoimmune and inflammatory diseases with varying degrees of success (Steward-Tharp et al, 2010). However, undesirable toxic side effects are still major obstacles in the use of these immunosuppressive agents (Smith et al, 2003; Clay and Pandya, 2011). …”

Section: Introductionmentioning

confidence: 99%

A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells

Wang

Chen

et al. 2017

Front. Microbiol.

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An endophytic fungus, Mycosphaerella nawae ZJLQ129, was isolated from the leaves of the traditional Chinese medicine Smilax china. From the fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) was isolated. Chemical modification of it to the amide derivative (-)mycousnine enamine (2), which is new to science, was found to have high and selective immunosuppressive activity: similar to cyclosporin A, (-)mycousnine enamine (2) selectively inhibited T cell proliferation, suppressed the expression of the surface activation antigens CD25 and CD69 and the formation and expression of the cytokines interleukin-2 as well as interferon γ in activated T cells, but did not show any effect on the proliferation of B cells and cancer cells (PANC-1 and A549) and the activation of macrophages. Furthermore, the cytotoxicity of (-)mycousnine enamine was lower than that of cyclosporin A, and its therapeutic index (TC50/EC50) was 4,463.5, which is five-fold higher than that of cyclosporin A. We conclude that (-)mycousnine enamine (2), the semi-synthestic product prepared from the native product (-)mycousnine (1) of the endophyte M. nawae is a novel effective immunosuppressant showing low toxicity and high selectivity.

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“…13 For pregnant women with AIBD, the delivery should be vaginal, as slow wound healing may occur after cesarean delivery, associated with corticosteroid use. 62 Autoimmune diseases in females usually occur after puberty and sexual activity. 63 After unprotected sexual intercourse, male sperm may be found into the peritoneal cavity of women exposing the immune system to foreign proteins.…”

mentioning

confidence: 99%

Investigation of comorbid autoimmune diseases in women with autoimmune bullous diseases: An interplay of autoimmunity and practical implications

Karakioulaki

Murrell

Kyriakou

et al. 2022

International Journal of Women’s Dermatology

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Autoimmune bullous diseases are a group of skin disorders resulting from an autoimmune reaction against intercellular adhesion molecules or components of the basement membrane of skin and mucosa. Autoimmune disorders often occur in patients with a history of another autoimmune disease and most autoimmune diseases have a striking female predominance. In this review, we aim to analyze the different associations of autoimmune bullous diseases with other autoimmune diseases and highlight the distinctiveness of the female gender in these associations.

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Minimizing Complications in Autoimmune Blistering Diseases

Cited by 8 publications

References 30 publications

Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

Assessing quality of life in patients with autoimmune bullous diseases using the Persian version of Treatment of Autoimmune Bullous Disease Quality of Life questionnaire finds similar effects in women as men

A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells

Investigation of comorbid autoimmune diseases in women with autoimmune bullous diseases: An interplay of autoimmunity and practical implications

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