Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant &lt;i&gt;Peganum harmala&lt;/i&gt; : research communication

Mirzaiedehaghi, M.

doi:10.4102/ojvr.v73i2.162

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…In this study 100 % of the sheep recovered after treatment but in another experiment reported by Mirzaiedehaghi (2006), the recovery rate was 65 %. The reasons for this apparent discrepancy in the success rate of the treatment, could be the different environmental conditions, and the small numbers of sheep we used.…”

Section: Discussioncontrasting

confidence: 50%

“…Three days after a febrile reaction had developed and the detection of schizonts in the prescapular lymph node smears, treatment of the lambs in Group A with the alkaloids of P. harmala was commenced intramuscularly at a dose of 5 mg of the dried material in 0.1 ml normal saline/kg body mass (Mirzaiedehaghi, 2006) once daily for 7 days. The lambs in Group B were untreated and served as controls.…”

Section: Methodsmentioning

confidence: 99%

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Effect of <i>Peganum harmala</i> (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Derakhshanfar¹,

Mirzaei²

2008

Onderstepoort J Vet Res

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Malignant theileriosis of sheep is a highly fatal, acute or subacute disease is caused by the tick-borne protozoan parasite, Theileria hirci. In this investigation ten healthy male lambs aged 5-6 months were randomly divided into two groups, A and B and were kept in isolated tick-proof pens. They were treated for internal and external parasite before commencement of the experiment. The lambs were experimentally infected with T. hirci by placing ticks Hyalomma anatolicum anatolicum infected with T. hirci on them. The ticks used in this survey had originally been isolated from sheep and colonies of them were established in an insectarium. Before and after infection rectal temperatures and clinical signs of the lambs were recorded, blood and prescapular lymph node smears were prepared and examined to determine the extent of the parasitaemia, and blood samples were analyzed to evaluate their haemoglobin (Hb) and packed cell volume (PCV) rates. Three days after the commencement of a febrile reaction and appearance of the schizonts in the lymph node smears, treatment of the lambs in Group A with an extract containing the alkaloids of Peganum harmala (wild rue) was commenced. Group B lambs were kept untreated controls. Before treatment there were no significant differences in the rectal temperature, parasitaemia rate, and the Hb and PCV values between animals in the two groups but after treatment significant differences in these values was detected (P < 0.05). After treatment, the clinical signs and parasites in the lymph node smears of the animals in Group A disappeared and they all animals recovered. These parameters in the animals of Group B progressed until their death. Pathological studies showed the characteristic lesions of theileriosis in lambs in Group B, but not in Group A. The results indicate a therapeutic effect of the alkaloids of P. harmala for treatment of ovine malignant theileriosis.

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Section: Discussioncontrasting

confidence: 50%

Section: Methodsmentioning

confidence: 99%

Effect of <i>Peganum harmala</i> (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Derakhshanfar¹,

Mirzaei²

2008

Onderstepoort J Vet Res

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“…The recovery rate of cattle from theileriosis was 78%, but in our previous study on natural malignant theileriosis in sheep, it was 65% (Mirzaiedehaghi, 2006). The reason for this discrepancy in the success rate of these 2 studies could be attributed to the different extracts of P. harmala.…”

Section: Discussionmentioning

confidence: 80%

“…Treatment with the extract containing the alkaloids of P. harmala was performed intramuscularly at a dose of 5 mg/kg body weight once daily for 5 days (Mirzaiedehaghi, 2006). All cattle with rectal tempera-268 Korean J. Parasitol.…”

Section: Methodsmentioning

confidence: 99%

Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala

Mirzaei

2007

Korean J Parasitol

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Theileria annulata, a protozoan parasite of cattle and domestic buffaloes, is transmitted by ticks of the genus Hyalomma, and causes a disease named Mediterranean or tropical theileriosis. In this research 50 cattle naturally infected with Theileria annulata were treated with the extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of the extract being 5 mg/kg per day. After the treatment, 39 cattle responded to the treatment and recovered, but 11 did not respond to the treatment and died. The recovery rate of animals treated with the extract of the plant Peganum harmala was 78%.

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“…Other investigators have shown that trivalent antimonial compounds were highly toxic to different Leishmania species in the promastigote form at concentrations ranging from 1.58 to 35.00 μg of Sb (III)/mL (20)(21)(22). Several studies have shown that different protozoan infections have been susceptible to P. harmala extract in varying degrees (23,24). The our results showed that there was no significant difference between plants extract and Glucantime (P>0.05) in MTT and IC50 test also NO production.…”

Section: Discussionmentioning

confidence: 99%

In vitro activity of Hyssopus officinalis, Tussilage farfara, Carum copticum extracts against Leishmania major in Iran

Tabatabaie¹,

Golestani²,

Akhlaghi³

et al. 2014

asb

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Leishmania is transmitted by sandflies that ingest the parasite in the amastigote phase resident within macrophages, then inoculate the promastigote phase into body hosts. The present study was conducted to evaluate the in vitro effects of alcoholic extract of Plants on L.major. The extract of aerial parts of plants were obtained by maceration. The in vitro experiments were performed on promastigotes to assess antileishmanial activity of the extracts using glucantime as 194 Fatemeh Tabatabaie et al.a reference. The extract of plants and glucantime solutions for biological testing were prepared in PBS at 0.05-0.1-0.2-0.4 μg/mL and 1μg/mL, respectively. All experiments were repeated at least three times in duplicate. For the extract of plants and glucantime, the concentration-response curve was plotted, from which IC50 values were determined also No and MTT assay were done. The different concentrations resulted in different optical densities or inhibitory percentages (P<0.05) so that extract of plants were effective against L. major in vitro. NO production the extract of plants showed significant in vitro antileishmanial activities.The Findings of this study indicate that these plants are effective against L.major in vitro.

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Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant <i>Peganum harmala</i> : research communication

Cited by 11 publications

References 3 publications

Effect of <i>Peganum harmala</i> (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Effect of <i>Peganum harmala</i> (wild rue) extract on experimental ovine malignant theileriosis : pathological and parasitological findings

Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala

In vitro activity of Hyssopus officinalis, Tussilage farfara, Carum copticum extracts against Leishmania major in Iran

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