Treatment of multiple eccrine hidrocystoma with oral isotretinoin following erbium-yttrium aluminum garnet laser

Abstract

Eccrine hidrocystomes (EH) are benign cystic tumors of dermal eccrine ducts. There is still no gold standard treatment option for EH because of the large number of lesions, the risk of cicatrization and the different treatment options offered. We offer combined oral isotretinoin and following erbium-yttrium aluminum garnet laser treatment as an alternative treatment option in difficult patients with EH.

Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

“…Pestoni et al 29 used concomitant tretinoin and fractional CO 2 laser on two patients for successful treatment of nodulocystic acne, resulting in improvement without significant adverse events. In addition, Demirkan et al 31 used a single session of Er:YAG laser and isotretinoin to successfully treat multiple eccrine hidrocystoma without recurrence at 1 year. No adverse events were reported.…”

“…It is important to consider the limitation of all studies included in this review, including pre‐intervention (eg, confounding, selection), peri‐intervention (eg, classification), and post‐intervention (eg, reporting) bias. Eight studies 7,8,18,19,21,22,29,31 were critically biased due to the inherent limitations of case reports and expert opinions of selective reporting and negative self‐controls. The remainder were moderately biased, due to no pre‐registered protocols, variable isotretinoin dosages and laser settings, and the subjective nature of outcome measures.…”