Concomitant use of isotretinoin and lasers with implications for future guidelines: An updated systematic review

Abstract

It is generally believed that intervention on skin while on isotretinoin or within 6 to 12 months after treatment can lead to prolonged healing and abnormal scarring. The objective of this systematic review is to evaluate the body of evidence on concomitant use of isotretinoin and lasers for adverse events as a consequence of treatment. A PRISMA-compliant systematic review (Systematic Review Registration Number: CRD42017056492) of 12 electronic databases was conducted for the terms "laser" and "isotretinoin" or associated brand names from inception until June 2020. Subsequent reference search of studies meeting predefined inclusion criteria were conducted, and all articles were evaluated for bias and assigned levels of evidence to facilitate data synthesis. The search strategy produced 29 studies. Of 871 patients included in the studies of interest, 12 experienced transient adverse effects that resolved spontaneously, and only two presented with keloid formation, both from case reports. This systematic review suggests the risk associated with concomitant isotretinoin and laser use is small to absent. Further studies are needed, but these results suggest that current contraindications may be overly cautious.

EGR1 Is a Critical Gene in Response of Human Keratinocyte to Blue Light Radiation

“…1,2 Since the benefits of laser application are significant, it can be expected that the use of lasers will achieve considerable progress in the near future. 3 On the other hand, the molecular mechanism of laser effects on the human body is not clear yet. 4 There are many documents about the molecular mechanism regarding the gene expression change of many genes after the treatment of the human body by diverse lasers.…”