Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study

Xue, Huan; Ye, Dan; Huang, Shiliu; He, Shujuan; Liu, Jing; Mu, Shengzhi; Li, You-Bao; Hu, Guanglei; Hu, Die; Wang, Zhao; Zeng, Weihui

doi:10.1007/s10103-022-03702-0

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Although keloid formation was the concern when isotretinoin was applied, 33,34 multiple studies reported that low dose isotretinoin is a safe option in recent years. 25,[35][36][37] No hypertrophic scars or keloids were observed in our study. Moreover, no hyperpigmentation or hypopigmentation occurred.…”

Section: Discussioncontrasting

confidence: 49%

“…Compared with FxPico alone, the combined therapy has a more obvious effect on the improvement of acne scar and lesions. Although keloid formation was the concern when isotretinoin was applied, 33,34 multiple studies reported that low dose isotretinoin is a safe option in recent years 25,35–37 . No hypertrophic scars or keloids were observed in our study.…”

Section: Discussionmentioning

confidence: 42%

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Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Xue

Huang

et al. 2023

Lasers Surg Med

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Purpose Acne scars are common in patients with moderate to severe acne. Isotretinoin is the first‐line treatment for those patients, but whether oral isotretinoin can improve acne scar is not clear. Picosecond lasers (FxPico) has been reported to improve acne scars. In the present study, we evaluated the clinical efficacy of low‐dose isotretinoin with or without FxPico treatment for acne scars. Materials and Methods A total of 48 patients with acne scars were enrolled and were randomly assigned to receive low dose oral isotretinoin or not. For all the patients in both treatment groups, one side of face were randomly assigned to be treated with picosecond laser. Assessments, including photos, échelle d'évaluation clinique des cicatrices d'acné (ECCA) and Global Acne Grading System (GAGS) score, the number of lesions, melanin and erythema indexes, transepidermal water loss were assessed at 0, 1, 2, and 3 month. Side effects, Dermatology Life Quality Index (DLQI) and satisfaction were recorded before and after the study. Results A total of 44 patients completed the study (24 received oral low dose isotretinoin and 20 did not). Low dose oral isotretinoin treated group showed significant improvement on ECCA (from 112.5 [50–180] to 105 [50–160]), GAGS score (from 12.6 ± 3.3 to 10.1 ± 3.0), the count of papules (from 4.3 ± 3.7 to 1.0 ± 1.5) than the blank group, and higher improvement were noticed after isotretinoin combined with FxPico. All the side effects were temporary and tolerable, no adverse effects were observed. Higher DLQI and patients' satisfaction were achieved by oral isotretinoin alone and isotretinoin combined with FxPico. Conclusions This is the first paper showing the improvement of scars by early low dose‐isotretinoin intervention with or without the combination of picosecond laser. Early intervention with oral low‐dose isotretinoin is effective for the treatment and prevention of acne scars, the combined therapy with FxPico can achieve better outcome.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 42%

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Xue

Huang

et al. 2023

Lasers Surg Med

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“…Specifically, the 1,064-nm PSNYL was used in 6 studies, 5 specifically for acne scarring, but with a variety of laser parameters. Xue and colleagues 29 used the 1,064 nm PSNYL laser with specific parameters, including a spot size of 7 mm, fluence of 1.2 J, frequency of 2 Hz, and pulse width of 450 ps, with each lesion receiving 2 passes. Kwon and colleagues 30 compared the 1,064-nm PSNYL (NAFL) and 1,550-nm Er:glass laser (P-DOE) for acne treatment, the PSNYL parameters were 450-picosecond pulse duration, fluence of 130 to 430 mJ/cm 2 , frequency of 5 to 10 Hz, and spot size of 10 mm with 4 to 8 passes, whereas the P-DOE parameters were 25 to 35 J/cm 2 at level 4 to 6 with 4 to 8 passes.…”

Section: Resultsmentioning

confidence: 99%

Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Aggarwal,

Rossi,

Puyana

et al. 2024

Dermatol Surg

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BACKGROUND Fractional nonablative lasers (NAFLs) have demonstrated efficacy and safety for treating dermatologic conditions in patients with darker skin phototypes. Nonablative lasers are preferred in darker skin tones due to lower risk of postinflammatory hyperpigmentation. OBJECTIVE This review aims to identify the ideal laser options and parameters for treating common dermatologic conditions in patients with skin types IV-VI. MATERIALS AND METHODS A comprehensive literature search was conducted on PubMed in May 2023. Of 1,065 articles were identified, and 40 articles met the inclusion criteria. The studies were classified based on design, dermatologic condition, and skin phototype of patients, and assigned levels of evidence according to the Modified Criteria of the Oxford Center of Evidence Based Medicine. RESULTS Strong level 1 evidence supports the treatment of melasma and atrophic scars using NAFL. Moderate level 2 evidence was found for using NAFL in acne vulgaris, striae, and skin rejuvenation; 45% of the studies examined skin types III-IV, 20% III-V, 7.5% II-IV, 5% II-V, 5% IV alone, and 2.5% I-IV. CONCLUSION Further research is needed to determine the optimal treatment modalities and parameters for skin types V and VI. Appropriate device selection and conservative treatment settings are crucial for optimizing outcomes and minimizing adverse events.

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Efficacy and safety comparison between pulsed dye laser and intense pulsed light configured with different wavelength bands in treating erythematotelangiectatic rosacea

Ruan,

Zheng,

Cai

2024

Lasers Med Sci

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Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study

Cited by 3 publications

References 51 publications

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Efficacy and safety of low‐dose oral isotretinoin monotherapy versus combined therapy with picosecond laser for the treatment of acne scars in Asian population

Review of Fractional Nonablative Lasers for the Treatment of Dermatologic Conditions in Darker Skin Phototypes

Efficacy and safety comparison between pulsed dye laser and intense pulsed light configured with different wavelength bands in treating erythematotelangiectatic rosacea

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