Treatment of malignant fibrous histiocytoma of the heart

Stevens, Craig W.; Sears-Rogan, Pamela; Bitterman, Pincas; Torrisi, J.

doi:10.1002/1097-0142(19920215)69:4<956::aid-cncr2820690420>3.0.co;2-o

Cited by 19 publications

(6 citation statements)

References 20 publications

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“…Surgery is the only treatment capable of improving outcome even after palliative resection, but long-term survivors are still anecdotal. Sporadic cases of long-term survivors treated with radiation therapy (Stevens et al 1992) and/or chemotherapy (Potter et (Demny. 1996).…”

Section: Discussionmentioning

confidence: 99%

Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience

Llombart-Cussac

Pivot²,

Contesso³

et al. 1998

Br J Cancer

139

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Section: Discussionmentioning

confidence: 99%

Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience

Llombart-Cussac

Pivot²,

Contesso³

et al. 1998

Br J Cancer

139

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“…Recommended therapy has often been complete or partial excision of the cardiac malignancy, followed by adjuvant radiation therapy and/or chemotherapy [3,32]. The literature contains reports of responses of inoperable cardiac and great vessel sarcoma to radiation therapy 1391, chemotherapy [40], and combination therapy [41], but experience is limited by the rarity of these malignancies. Doxorubicin chemotherapy and radiation therapy are cardiotoxic.…”

Section: Treatment Of Cardiac Andmentioning

confidence: 99%

Sarcomas related to the heart and vasculature

Raaf

1994

Seminars in Surgical Oncology

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Soft tissue sarcoma is the most common malignant neoplasm of the heart, pericardium, and great vessels. Its presentation is infrequent, nonspecific, and subtle. For example, emboli from these tumors to the lungs or peripheral arteries may mimic thrombotic embolic disease. New noninvasive techniques such as echocardiography and magnetic resonance imaging (MRI) aid in diagnosis and preoperative assessment. Angiosarcoma, the most common cardiac sarcoma, is aggressive and usually arises in the right atrium. Kaposi's sarcoma of the heart has been found in patients with AIDS and in immunosuppressed organ transplant recipients. Most primary sarcomas of the aorta and pulmonary artery (the elastic arteries) show minimal differentiation and are classified as "intimal, sarcomas," whereas leiomyosarcomas predominate in the muscular arteries and great veins. Surgical resection of any sarcoma of the vasculature, when feasible, is technically challenging but may result in cure or palliation. Adjuvant chemotherapy and radiation therapy can also relieve symptoms and prolong survival.

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“…In a case report of a patient with cardiac MFH, a 5,600 cGy dose of radiotherapy was delivered in conjuction with resection and provided clinical remission for 16 months. 13 The role of heart transplantation in the treatment of primary cardiac sarcomas remains controversial. Our patient is the second identified in the literature to undergo orthotopic heart transplantation for primary cardiac MFH.…”

Section: Discussionmentioning

confidence: 99%