Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience

Llombart-Cussac, Antonio; Pivot, Xavier; Contesso, G.; Rhor-Alvarado, A.; Delord, Jean‐Pierre; Spielmann, M.; Tursz, T; Cesne, Axel Le

doi:10.1038/bjc.1998.733

Cited by 139 publications

(106 citation statements)

References 25 publications

(11 reference statements)

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“…Patients with primary cardiac angiosarcoma had a shorter median survival of seven months and median disease -free progression interval of four months compared to other histological types (8). In present case, radiochemotherapy after surgical resection was effective because it inhibited aggressiveness of the angiosarcoma.…”

Section: Duscussionmentioning

confidence: 65%

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Three-year survival in primary cardiac angiosarcoma

Fukunaga

Kitai²,

Imai³

et al. 2017

J. Med. Invest.

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: A healthy 18-year-old girl was referred to our hospital for further evaluations of cardiac angiosarcoma. Transthoracic echocardiography showed an immobile 4.6 cm 3.7 cm cardiac mass. The mass was occupying right atrial chamber and partially, invading into annulus of tricuspid valve on transesophageal echocardiography. At surgery, the mass was seen to be protruding from right atrial appendage and adhering to right side of pericardium. The histological findings were consistent with cardiac angiosarcoma and immunological staining was positive for CD34 and CD31. Afterward, although she received radiochemotherapy, she died of metastasis of cardiac angiosarcoma more than three years after surgical resection.

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Section: Duscussionmentioning

confidence: 65%

“…Liombart-Cussac et al reported that only a surgical radical resection was found to be significantly associated with longer survival. They also found that adjuvant chemotherapy postoperatively failed to modify the natural course of this disease (8). Primary tumor resection can contribute to improve median survival (3).…”

Section: Duscussionmentioning

confidence: 99%

Three-year survival in primary cardiac angiosarcoma

Fukunaga

Kitai²,

Imai³

et al. 2017

J. Med. Invest.

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“…En estos casos no existe una pauta clara de tratamiento complementario 9 . En sarcomas de partes blandas, el uso de quimioterapia complementaria es habitual.…”

Section: Comentariosunclassified

Autotrasplante cardiaco en el tratamiento quirúrgico de tumores cardiacos primarios: Caso clínico

A¹,

S²,

H³

et al. 2012

Rev. méd. Chile

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“…Some authors claim a beneficial effect for chemotherapy, 19,22,23) whereas others express no effect at all. 17,24) Vol 42 No 3 Survival data: Burke,et al 5) and other authors have found that histological grading correlates with survival. High mitotic activity and necrosis is associated with a poor survival outcome.…”

Section: )mentioning

confidence: 99%

Ventricular Outflow Tract Obstruction Secondary to Leiomyosarcoma of the Right Ventricle.

et al. 2001

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SUMMARYPrimary leiomyosarcomas of the heart, particularly those affecting the right ventricle, are uncommon. We report the case of a 70-year-old Belgian woman presenting with the symptoms of progressive exertional dyspnea and left-sided pleuritic pain. A leiomyosarcoma which originated from the right lateral ventricle wall, causing pulmonary outflow obstruction. was diagnosed. Pathology revealed a neoplasm with a myxoid stroma, high mitotic activity and nuclei expressing atypia. Immunohistochemical staining was positive for vimentine and desmin. Seven months after complete surgical resection the tumor relapsed.This case demonstrates the poor outcome, the high relapse rate and inefficiency of treatment associated with primary cardiac leiomyosarcomas. The current literature regarding the incidence, diagnostic techniques, treatment strategies and survival rates of this rare but terminal disease is reviewed. (Jpn Heart J 2001; 42: 377-386)

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Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience

Cited by 139 publications

References 25 publications

Three-year survival in primary cardiac angiosarcoma

Three-year survival in primary cardiac angiosarcoma

Autotrasplante cardiaco en el tratamiento quirúrgico de tumores cardiacos primarios: Caso clínico

Ventricular Outflow Tract Obstruction Secondary to Leiomyosarcoma of the Right Ventricle.

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