Three-year survival in primary cardiac angiosarcoma

Fukunaga, Naoto; Kitai, Takeshi; Imai, Yukihiro; Furukawa, Yutaka; Koyama, Tadaaki

doi:10.2152/jmi.64.181

Cited by 6 publications

(11 citation statements)

References 7 publications

(5 reference statements)

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“…Around 75% of angiosarcomas are located in the right atrium. The lateral/free wall is the most common site, while the interatrial septum is frequently preserved [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…Dyspnea is present in 59%-88% of patients with such a diagnosis [2,7]. It is usually multifactorial: vulnerability of the tricuspid valve due to the location in the right atrium, pericardial effusion with or without cardiac tamponade, right ventricle obstruction due to tumor's growth, pleural effusion, and lung metastasis [4,9,11,12]. Less frequently, patients may present hemopericardium, hemoptysis, anemia, pulmonary embolism, and superior vena cava syndrome [10,12].…”

Section: Discussionmentioning

confidence: 99%

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Primary Cardiac Angiosarcoma: A Rare and Fatal Diagnosis

Gonçalves¹,

Nunes²,

Vieira³

et al. 2021

Cureus

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Primary cardiac angiosarcoma is a rare malignant neoplasm and occurs most frequently in middle-aged males. It has an aggressive nature, with highly variable clinical features, which results in delayed diagnosis and high mortality.We report a 19-year-old man presented to the ED with a three-month history of hemoptysis and one-week history of anterior chest pain. Additionally, an aortic diastolic murmur grade II/VI was found on physical examination. Thoracic CT scan revealed bilateral dispersed hypodense pulmonary nodes with peripheral halo, alveolar densification, and pericardial effusion. The transthoracic echocardiogram confirmed sizeable pericardial effusion and bicuspid aortic valve, without other significant findings. A pericardiocentesis removed 1300 mL of hemorrhagic fluid, consistent with an exudate without malignant cells. Both cardiac magnetic resonance and transesophageal echocardiogram revealed a large mass on the right atrium's anterior wall. Mass biopsy was performed, revealing malignant cardiac angiosarcoma. The biopsy of the lung lesions was compatible with lung metastasis of primary cardiac angiosarcoma. The patient was submitted to palliative chemotherapy but died 12 months after the diagnosis.

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“…Around 75% of angiosarcomas are located in the right atrium. The lateral/free wall is the most common site, while the interatrial septum is frequently preserved [4,7].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Cardiac Angiosarcoma: A Rare and Fatal Diagnosis

Gonçalves¹,

Nunes²,

Vieira³

et al. 2021

Cureus

View full text Add to dashboard Cite

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“…For resectable cases, surgical resection combined with chemotherapy and local radiotherapy might be useful. Fukunaga et al recently reported a three-year survival in a patient with primary cardiac angiosarcoma, who received surgical resection followed by chemoradiotherapy (10).…”

Section: Discussionmentioning

confidence: 99%

Dramatic Recovery from Cardiovascular Collapse: Paclitaxel as an Urgent Treatment for Primary Cardiac Angiosarcoma

et al. 2021

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We herein report three patients with cardiac angiosarcoma who were directly admitted to the intensive-care unit for hemodynamic instability with circulatory collapse. Using a multidisciplinary cardio-oncologic approach, we diagnosed their condition as angiosarcoma by an invasive biopsy and urgently started weekly paclitaxel administration despite their poor performance status. Their vital signs were soon stabilized, leading to the patients' discharge from the hospital. Although no treatment guidelines for cardiac angiosarcoma have been established, chemotherapy with paclitaxel can be an option for cases presenting with hemodynamic instability.

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“…[ 19 ] Surgical resection remains the first-line treatment of choice when no evidence of metastases exists and myocardial resection is reparative. [ 20 ] If the tumor is resectable, adjuvant therapies, including chemotherapy, radiotherapy and targeted therapy, can improve the chances of survival because of the high probability of metastasis. [ 21 – 24 ] Among the surgical therapeutic methods, heart transplantation has also been suggested, although many moral and social dilemmas exist.…”

Section: Discussionmentioning

confidence: 99%

Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy

et al. 2018

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Rationale:Primary cardiac tumors are very rare, and angiosarcoma accounts for about 33% of all primary malignant cardiac tumors. Primary cardiac epithelioid angiosarcoma is a highly aggressive and difficult to diagnose tumor, with early systemic metastasis and poor prognosis.Patient concerns:A 35-year-old Han male experienced sudden severe palpitation and moderate dyspnea. The patient received a whole body F-18 fluoro-deoxyglucose positron emission tomography (18F-FDG PET)/computed tomography (CT) scan, the scan showed a large mass in the right atrium (RA) and numerous pulmonary nodules in both lungs.Diagnoses:The patient was diagnosed as right atrial epithelioid angiosarcoma with multiple pulmonary metastasis by pulmonary biopsy through CT-guided percutaneous transthoracic fine needle aspiration.Interventions:The patient received a cycle of chemotherapy with docetaxel and gemcitabine, followed by another cycle with epirubicin and ifosfamide.Outcomes:The chemotherapy was ineffective. After the two cycles, the bilateral pleural effusion steadily increased, the patient had severe dyspnea and palpitation, and died three weeks later, with an overall survival of 2.5 months.Lessons:Primary angiosarcoma of heart is a very rare and aggressive disease, and its diagnosis and treatment are difficult. Most patients may have systemic metastasis at diagnosis, and have a very short survival without surgical resection. Hence, early diagnosis and surgical resection is extremely important to treat this disease.

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Three-year survival in primary cardiac angiosarcoma

Cited by 6 publications

References 7 publications

Primary Cardiac Angiosarcoma: A Rare and Fatal Diagnosis

Primary Cardiac Angiosarcoma: A Rare and Fatal Diagnosis

Dramatic Recovery from Cardiovascular Collapse: Paclitaxel as an Urgent Treatment for Primary Cardiac Angiosarcoma

Right atrial epithelioid angiosarcoma with multiple pulmonary metastasis confirmed by multimodality imaging-guided pulmonary biopsy

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