Treatment of Male Infertility

Glezerman, Marek; Lunenfeld, Bruno

doi:10.1007/978-3-642-65117-5_11

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…However, we agree with other authors that conventional light microscopy cannot identify the entire variety of morphological defects that can occur in spermatozoon subcellular organelles, especially in head structure [18,32,40]. In contradistinction, electron microscopy can correctly identify the ultramorpological state of the sperm cell subcellular organelles and thus determine the specific sperm quality.…”

Section: Introductionsupporting

confidence: 88%

“…Sperm morphology assessment according to strict criteria is widely accepted to be a valuable and stable test for predicting the in vivo [18] and in vitro [21,28] sperm fertilizing capacity. However, we agree with other authors that conventional light microscopy cannot identify the entire variety of morphological defects that can occur in spermatozoon subcellular organelles, especially in head structure [18,32,40].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Ultramorphological Analysis of Human Sperm: Diagnosis and Management of Male Infertility

Bartoov

Eltes

Reichart

et al. 1999

Archives of Andrology

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Section: Introductionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Quantitative Ultramorphological Analysis of Human Sperm: Diagnosis and Management of Male Infertility

Bartoov

Eltes

Reichart

et al. 1999

Archives of Andrology

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“…Electron microscopy has revealed several structural abnormalities in spermatozoa of infertile men involving mainly the nucleus and acrosome (Bartoov & Fisher, 1982; Zamboni, 1987; Lipitz et al ., 1992; Mundy et al ., 1994). Such abnormalities have been correlated with the fertilizing potential of spermatozoa, both in vitro and in vivo (Mashiach et al ., 1992; Glezerman & Bartoov, 1993). Treatment with FSH has proved to be effective in improving the ultrastructural features of semen (Bartoov et al ., 1994; Baccetti et al ., 1997).…”

Section: Introductionmentioning

confidence: 99%

Effects of long-term treatment with human pure follicle-stimulating hormone on semen parameters and sperm-cell ultrastructure in idiopathic oligoteratoasthenozoospermia

Arnaldi¹,

Balercia²,

Barbatelli

et al. 2000

Andrologia

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Ten subfertile men affected by idiopathic oligoteratoasthenozoospermia and exhibiting normal serum hormone levels received a long-term treatment with human pure follicle-stimulating hormone (hp-FSH) (150 IU, intramuscularly, three times per week for 6 months). Semen parameters and ultrastructural features of spermatozoa were evaluated before and after therapy. The results showed an increase in sperm cell concentration and, more interestingly, motility. Electron microscopic examination revealed an improved fine architectural pattern, mainly involving acrosome, head and chromatin and middle-piece, in accordance with the positive changes of functional data. No significant changes of hp-FSH treatment on serum hormone levels were observed, since the latter were found to be substantially unchanged after 6 months of therapy. The present data suggest: (i) the benefit of hp-FSH administration in idiopathic oligoteratoasthenozoospermia, when hormone parameters support a substantial integrity of spermatogenetic microenvironment and (ii) an optimal effect after long-term (6 months) therapy.

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“…Of the different types of male infertility, the oligo/terato/asthenospermia (OTA) syndrome is the most difficult to treat, since in most cases sperm concentration, motility, and morphology are linked one to the other. 2 Two approaches toward treatment of the subfertile male are suggested: In the in vivo approach therapeutic regimens include substitute treatment in an attempt to overcome hormonal deficiency, combined with surgical correction of anatomic defects such as varicocele, obstructions, etc. When the medical and surgical modes of treatment fail, the in vitro approach is suggested, i.e., improvement of sperm quality by laboratory techniques for homologous artificial insemination (AIH).…”

mentioning

confidence: 99%