Treatment of Lisch Corneal Dystrophy With Photorefractive Keratectomy and Mitomycin C

Wessel, Matthew M.; Sarkar, Jayati S.; Jakobiec, Frederick A.; Dang, Natasha; Bhat, Pooja; Michaud, Norman; Starr, Chauncey

doi:10.1097/ico.0b013e3181ec8e26

Cited by 27 publications

(19 citation statements)

References 10 publications

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“…In vivo confocal microscopy demonstrated solitary, dark and well‐demarcated lesions in round and oval configurations. These clinical findings were all consistent with previously documented reports of Lisch corneal epithelial dystrophy, as described in the ophthalmic literature …”

Section: Case Reportsupporting

confidence: 92%

A corneal tulip? Assessing corneal opacities in Lisch corneal epithelial dystrophy

Chou¹,

Lockington²

2018

Clinical and Experimental Optometry

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Section: Case Reportsupporting

confidence: 92%

A corneal tulip? Assessing corneal opacities in Lisch corneal epithelial dystrophy

Chou¹,

Lockington²

2018

Clinical and Experimental Optometry

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“…Alcohol-assisted epithelial debridement and contact lens placement have both been successfully attempted, with some degree of recurrence reported 7,9 . Treatment using photorefractive keratectomy (PRK) combined with mitomycin C (MMC) application has also been described with minimal recurrence 3,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Histopathologic analysis of superficial scrapings from affected corneal epithelium demonstrates sheets of cells with a bubbly cytoplasm and vacuoles made of glycogen, prevalent in the suprabasalar cell layers 1,3–7 . Slit-lamp examination reveals varying shapes of homogenous gray defects often in whorled and fimbriated patterns 1–9 .…”

Section: Introductionmentioning

confidence: 99%

“…A few small studies have investigated various diagnostic modalities for this dystrophy. In vivo confocal microscopy has shown well-demarcated regions of uniformly affected cells with hyporeflective nuclei and hyperreflective cytoplasm 3,4,6,9 . Additionally, electron microscopy reveals the vacuoles to contain a laminated and clumped substance or whorled material 3,4,7 .…”

Section: Introductionmentioning

confidence: 99%

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High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

Pole¹,

Sise

Joag³

et al. 2016

Cornea

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Purpose To describe a case of Lisch epithelial corneal dystrophy (LECD) and present its unique characteristics on high-resolution optical coherence tomography (HR-OCT). Methods A 78-year-old man with whorled corneal epithelial opacities in the right eye was referred for evaluation of ocular surface squamous neoplasia. Clinical evaluation, photos, and HR-OCT images of involved cornea were obtained and scrapings of the affected cornea were sent for histopathologic analysis. Results Clinically the patient presented with a opalescent whirling epithelium in a linear pattern encroaching on the visual axis. HR-OCT showed normal thickness epithelial hyperreflectivity of involved cornea without stromal involvement, along with sharply demarcated borders of unaffected tissue. Histopathologic findings demonstrated vacuolated PAS-positive cells throughout the epithelial layers consistent with LECD. Conclusions HR-OCT was able to provide useful information to rule out ocular surface squamous neoplasia, and confirm the clinical impression of LECD at the time of clinical examination. HR-OCT shows promise as an adjunctive diagnostic tool for ocular surface lesions and pathologies.

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“…In some cases, debridement might be helpful. Phototherapeutic keratectomy (PTK) can be beneficial in some cases [32].…”

Section: Lisch Epithelial Corneal Dystrophy (Lecd)mentioning

confidence: 99%

Corneal Dystrophies and Degenerations

Alkatan¹,

Alkheraiji²,

Alzahem³

2019

Frontiers in Ophthalmology and Ocular Imaging

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The cornea is a complex structure with complex functions aiming to protect the internal ocular tissues and transmit and refract the coming light rays. Corneal dystrophies are a group of relatively infrequent genetic corneal disorders in which an abnormal material accumulates in the cornea causing variable loss of its clarity. On the other hand, corneal degenerations are more common and usually result from physiologic changes related to aging, particular disease, or long-standing environmental insults to the cornea. Ectatic corneal disorders are usually characterized by bilateral loss of corneal biomechanical strength leading to progressive thinning and bulging of the cornea with resultant astigmatism and decreased visual acuity. In this chapter, we will describe the basic embryological, anatomical, histologic, and physiological features of the cornea. Then, we will go over the clinical, histopathologic, medical, and surgical aspects of dystrophic, degenerative, and ectatic corneal disorders.

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Treatment of Lisch Corneal Dystrophy With Photorefractive Keratectomy and Mitomycin C

Abstract: Although the whorled inclusions represent a novel finding, the overall clinical and microscopic analysis was consistent with Lisch dystrophy. Surface ablation with MMC should be considered as a treatment option for this disease.

Cited by 27 publications

References 10 publications

A corneal tulip? Assessing corneal opacities in Lisch corneal epithelial dystrophy

A corneal tulip? Assessing corneal opacities in Lisch corneal epithelial dystrophy

High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

Corneal Dystrophies and Degenerations

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