A corneal tulip? Assessing corneal opacities in Lisch corneal epithelial dystrophy

Chou, Chi-Ying; Lockington, David

doi:10.1111/cxo.12555

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…In review of the literature, corneal epithelial debridement, also referred to as epitheliectomy or superficial keratectomy, has been the traditional management approach for LECD. [2][3][4][6][7][8]10,11 Unfortunately, recurrence was common, noted in 7 of 9 eyes of 9 patients. By contrast, no recurrences were noted over a 2-year period in 2 eyes of 2 patients who underwent keratolimbal autograft transplantation and keratectomy with cauterization of the limbal focus of origin.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Recurrent Lisch Epithelial Corneal Dystrophy Treated With 5-Fluorouracil: A Case Report and Review of the Literature

Amer

Arze

Sayegh

et al. 2022

Cornea

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The aim of the study was to describe a case of Lisch epithelial corneal dystrophy (LECD), review its clinical and histopathological features and diagnostic imaging, and introduce a novel treatment approach using topical 5-fluorouracil (5-FU).Methods: A 65-year-old woman presented with a recurrent leftsided corneal lesion consistent with LECD. The lesion was evaluated clinically, with high-resolution optical coherence tomography (HR-OCT), and histologically. The lesion was successfully treated with two 1-week cycles of topical 5-FU.Results: Slit-lamp examination showed an opalescent, whorlshaped corneal lesion. HR-OCT revealed a trapezoidal area of normal thickness epithelial hyperreflectivity. Histopathology demonstrated a mucosal epithelium with foamy cytoplasm and increased cell size consistent with LECD. Treatment with topical 5-FU resulted in marked clearance of the corneal lesion on slit-lamp examination and HR-OCT.Conclusions: 5-FU may be considered as a treatment option for LECD.

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