Treatment of ligature-induced peri-implantitis defects by regenerative procedures. Part II. A histometric study in dogs.

Abstract

The purpose of this study was to evaluate, by histometric analysis, re-osseointegration following treatment of ligature-induced peri-implantitis in dogs. Five dogs were used in this study. Their mandibular premolars (P2, P3 and P4) were first removed. After 3 additional months of healing, two titanium implants were placed on each side of the mandible. After 3 months, the abutment connection was performed and experimental peri-implantitis was induced by placing cotton ligatures in a submarginal position. Ligatures and abutments were removed after one month and the peri-implant bone defects were randomly assigned to one of the treatments: debridement, debridement plus guided-bone regeneration, debridement plus mineralized-bone graft, and debridement plus guidedbone regeneration associated with mineralized-bone graft. Five months post-treatment, the degree of bone contact with the implant surface and the bone area within the threads were measured in 12 threads, the 6 most coronal at each side of each implant. One-way analysis of variance did not reveal statistically significant differences between the treatment modalities (p > 0.05). Within the limits of the present study, it can be concluded that there is a limited possibility of reosseointegration around implant surfaces previously exposed by ligature-induced peri-implantitis.

Comparison of naturally occurring and ligature‐induced peri‐implantitis bone defects in humans and dogs

“…However, unfortunately, there are currently no data evaluating configurations and sizes of ligature-induced peri-implant bone defects in dogs and naturally occurring lesions in humans. In particular, previous animal studies using beagle and labrador dogs merely reported that ligatures were removed when radiographic observation revealed an initial bone loss of approximately 30-50% (Grunder et al 1993;Jovanovic et al 1993;Ericsson et al 1996;Persson et al 1996;Hü rzeler et al 1997;Machado et al 1999;Persson et al 1999;Wetzel et al 1999;Machado et al 2000;Deppe et al 2001;Nociti et al 2001aNociti et al , 2001bPersson et al 2001aPersson et al , 2001bPersson et al , 2004. However, a limited number of these studies provided some clinical figures illustrating the defect configuration of ligatureinduced peri-implant bone loss in some implants.…”

Surgical treatment of peri‐implantitis

“…With regard to reosseointegration, the use of membranes alone and graft material alone tended to give better results than open debridement alone. Overall the best results for both reosseointegration and bone fill tended to occur when a combination of both GBR and graft material was used despite some studies which showed no benefit over debridement alone (Machado et al 1999, 2000, Nociti et al 2000, 2001a, b).…”

Treatment of peri‐implantitis with deproteinised bovine bone and tetracycline: a case report

“…Surgical treatment procedures of peri‐implantitis around titanium implants have previously been evaluated in humans 1–3 and animals 4,5 , and protocols such as air‐powder abrasives 6 , citric acid 7 and antimicrobial agents 8 have been suggested for the detoxification procedures.…”