Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. survey and analysis of the evolution of phytotherapy knowledge amongst Wayãpi Indians

Odonne, Guillaume; Berger, Franck; Stien, Didier; Grenand, Pierre; Bourdy, Geneviève

doi:10.1016/j.jep.2011.07.044

Cited by 46 publications

(31 citation statements)

References 33 publications

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“…The use of C. papaya has been recurrent in the traditional medicine having a significant number of reports due to their properties for the treatment such as skin ulcers [17] and antiprotozoal activity against Leishmania amazonensis [18], Trichomonas vaginalis [6], and Plasmodium falciparum ( P. falciparum ) [19]. The antiprotozoal activity of the chloroform crude extract of C. papaya during the subacute and chronic phase of Chagas' disease is demonstrated in this study in concordance with previous reports [7].…”

Section: Resultsmentioning

confidence: 99%

In Vivo Antiprotozoal Activity of the Chloroform Extract from Carica papaya Seeds against Amastigote Stage of Trypanosoma cruzi during Indeterminate and Chronic Phase of Infection

Jiménez‐Coello

Acosta-Viana

Ortega‐Pacheco

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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In order to evaluate the antiprotozoal activity of the chloroform extract of Carica papaya seeds during the subacute and chronic phase of infection of Trypanosoma cruzi, doses of 50 and 75 mg/kg were evaluated during the subacute phase, including a mixture of their main components (oleic, palmitic, and stearic acids). Subsequently, doses of 50 and 75 mg/kg in mice during the chronic phase of infection (100 dpi) were also evaluated. It was found that chloroform extract was able to reduce the amastigote nests numbers during the subacute phase in 55.5 and 69.7% (P > 0.05) as well as in 56.45% in animals treated with the mixture of fatty acids. Moreover, the experimental groups treated with 50 and 75 mg/kg during the chronic phase of the infection showed a significant reduction of 46.8 and 53.13% respectively (P < 0.05). It is recommended to carry out more studies to determine if higher doses of chloroformic extract or its administration in combination with other antichagasic drugs allows a better response over the intracellular stage of T. cruzi in infected animal models and determine if the chloroform extract of C. papaya could be considered as an alternative for treatment during the indeterminate and chronic phase of the infection.

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Section: Resultsmentioning

confidence: 99%

In Vivo Antiprotozoal Activity of the Chloroform Extract from Carica papaya Seeds against Amastigote Stage of Trypanosoma cruzi during Indeterminate and Chronic Phase of Infection

Jiménez‐Coello

Acosta-Viana

Ortega‐Pacheco

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…A previous study demonstrated the potency and cost effectiveness of C. papaya fruit when applied topically in the treatment of chronic ulcers in Jamaica [21]. In a recent study, C. papaya was listed as one of the plants used in the treatment of leishmaniasis [22]. It has been reported as accessible, nontoxic, and prophylactic and to be a promising monotherapy against intestinal parasitosis in tropical countries [23].…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts fromCarica papayaLeaves

Melariri

Campbell

Etusim

et al. 2011

Journal of Parasitology Research

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We investigated the antiplasmodial properties of crude extracts from Carica papaya leaves to trace the activity through bioassay-guided fractionation. The greatest antiplasmodial activity was observed in the ethyl acetate crude extract. C. papaya showed a high selectivity for P. falciparum against CHO cells with a selectivity index of 249.25 and 185.37 in the chloroquine-sensitive D10 and chloroquine-resistant DD2 strains, respectively. Carica papaya ethyl acetate extract was subjected to bioassay-guided fractionation to ascertain the most active fraction, which was purified and identified using high-pressure liquid chromatography (HPLC) and GC-MS (Gas chromatography-Mass spectrometry) methods. Linoleic and linolenic acids identified from the ethyl acetate fraction showed IC50 of 6.88 μg/ml and 3.58 μg/ml, respectively. The study demonstrated greater antiplasmodial activity of the crude ethyl acetate extract of Carica papaya leaves with an IC50 of 2.96 ± 0.14 μg/ml when compared to the activity of the fractions and isolated compounds.

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“…Changes in medicinal plant use can be perceived as “continuity” (maintenance), “disjunction” (same species but new context or conceptual background), “discontinuity” (abandonment) and synchronism (substitution and adoption; see Bye et al, 1995). Odonne et al (2011) found only one out of five previously described plant species used by the Wayãpi against leishmaniasis still in use, while previously not reported species are now relied upon. Generally field studies on medical ethnobotany show “snapshots,” i.e., the status quo of medicinal plant use for a certain community and point in time.…”

Section: Diachronic Studies and Bioprospecting Ancient Textsmentioning

confidence: 91%

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

Leonti¹,

Casu²

2013

Front. Pharmacol.

168

111

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The ethnopharmacological approach toward the understanding and appraisal of traditional and herbal medicines is characterized by the inclusions of the social as well as the natural sciences. Anthropological field-observations describing the local use of nature-derived medicines are the basis for ethnopharmacological enquiries. The multidisciplinary scientific validation of indigenous drugs is of relevance to modern societies at large and helps to sustain local health care practices. Especially with respect to therapies related to aging related, chronic and infectious diseases traditional medicines offer promising alternatives to biomedicine. Bioassays applied in ethnopharmacology represent the molecular characteristics and complexities of the disease or symptoms for which an indigenous drug is used in “traditional” medicine to variable depth and extent. One-dimensional in vitro approaches rarely cope with the complexity of human diseases and ignore the concept of polypharmacological synergies. The recent focus on holistic approaches and systems biology in medicinal plant research represents the trend toward the description and the understanding of complex multi-parameter systems. Ethnopharmacopoeias are non-static cultural constructs shaped by belief and knowledge systems. Intensified globalization and economic liberalism currently accelerates the interchange between local and global pharmacopoeias via international trade, television, the World Wide Web and print media. The increased infiltration of newly generated biomedical knowledge and introduction of “foreign” medicines into local pharmacopoeias leads to syncretic developments and generates a feedback loop. While modern and post-modern cultures and knowledge systems adapt and transform the global impact, they become more relevant for ethnopharmacology. Moreover, what is traditional, alternative or complementary medicine depends on the adopted historic-cultural perspective.

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Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. survey and analysis of the evolution of phytotherapy knowledge amongst Wayãpi Indians

Cited by 46 publications

References 33 publications

In Vivo Antiprotozoal Activity of the Chloroform Extract from Carica papaya Seeds against Amastigote Stage of Trypanosoma cruzi during Indeterminate and Chronic Phase of Infection

In Vivo Antiprotozoal Activity of the Chloroform Extract from Carica papaya Seeds against Amastigote Stage of Trypanosoma cruzi during Indeterminate and Chronic Phase of Infection

Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts fromCarica papayaLeaves

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

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