Treatment of Late-Onset Hearing Loss in Infants With Congenital Cytomegalovirus Infection

Amir, Jacob; Attias, Joseph; Pardo, Joseph

doi:10.1177/0009922813510204

Cited by 31 publications

(42 citation statements)

References 15 publications

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“…Начало антивирусной терапии в возрасте старше 30 дней жизни считается не эффективным [40], хотя ряд авторов свидетельствует обратное [41,42]. В исследованиях Amir J. et.…”

Section: лечениеunclassified

The modern view of congenital cytomegalovirus infection: diagnosis, treatment and prevention

et al. 2019

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A literature review of the works of foreign and domestic authors is devoted to modern approaches to the diagnosis, treatment and prevention of congenital cytomegalovirus infection (cCMV). The data of international consensuses are presented: «Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management» adopted by the cCMV group from the European society for pediatric infectious diseases (ESPID) in Leipzig, Germany in 2015, and «Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy» by an informal International Congenital Cytomegalovirus Recommendations Group (ICCRG), established in Brisbane, Australia in 2015 as part of the 5th International cCMV Conference about evidence-based treatment cCMV using antiviral drugs and immunotherapy. Particular attention is paid to the prevention of cCMV in both pregnant and newborns, as well as data from international studies on the cytomegalovirus vaccination.

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Section: лечениеunclassified

The modern view of congenital cytomegalovirus infection: diagnosis, treatment and prevention

et al. 2019

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“…Despite many case reports and cohort studies, data from only 2 RCTs on antiviral treatment for cCMV have been published [ 12 , 13 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. A phase III RCT, primarily assessing the hearing outcomes of newborns with cCMV, was conducted by the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group (CASG) [ 12 ].…”

Section: Benefit Of Antiviral Therapymentioning

confidence: 99%

“…The highest quality evidence available is limited to retrospective case series of small numbers of babies treated outside the newborn period. Amir et al [ 68 ] reported on 21 children, the majority of which had asymptomatic cCMV or only lenticulostriatal vasculopathy, which were treated with antivirals over a 9 to 12 month period starting at a median age of 8 months. At the last follow-up (median age of 24 months), hearing impairment improved in 29 of 35 ears evaluated.…”

Section: Benefit Of Antiviral Therapymentioning

confidence: 99%

Potential Benefit of Selective CMV Testing after Failed Newborn Hearing Screening

Kummer

Marcrum

2018

IJNS

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Evidence-based guidelines for the prevention, diagnosis and treatment of congenital cytomegalovirus (cCMV) were recently released by two independent expert groups. Of particular emphasis was the relationship between cCMV and sensorineural hearing loss (SNHL), a major component of the virus’ overall disease burden. In this study, a literature review was performed to estimate the proportion of cCMV-related SNHL cases, which might be identified through selective cCMV testing following failed newborn hearing screening. Furthermore, it was of interest to estimate the potential benefit of emerging antiviral therapies. Currently, at most 10% of cCMV-related SNHL is likely to be identified clinically. Through use of a selective cCMV testing protocol, however, a significant improvement in the identification rate can be achieved. Recent expert group statements strongly recommend antiviral therapy in cases of moderate-to-severe disease, especially in the presence of central nervous system involvement. Though differences exist between recommendations in instances of isolated SNHL or SNHL in combination with only mild symptoms, the majority of experts in both groups offered at least a weak recommendation for antiviral treatment. Available results suggest antiviral treatment could therefore benefit a meaningful proportion of newborns referred for cCMV testing following failed newborn hearing screening.

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“…Во время проведения аудиологического скрининга новорожденных с бессимптомной формой врожденной ЦМВИ в раннем послеродовом периоде методом отоакустической эмиссии и регистрации слуховых вызванных потенциалов такие дети, как правило, показывают нормальные результаты. Развитие прогрессирующей СНТ часто является первым симптомом наличия ЦМВИ [24]. Средний возраст выявления тугоухости на первом году жизни составляет 7,4±3,7 мес [24].…”

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“…Развитие прогрессирующей СНТ часто является первым симптомом наличия ЦМВИ [24]. Средний возраст выявления тугоухости на первом году жизни составляет 7,4±3,7 мес [24]. Однако нарушение слуха может обнаруживаться и в более поздние сроки, при этом средний возраст манифестации СНТ при инаппарантной форме ЦМВИ составляет 44, а при клинической -33 мес [25].…”

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Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing

Boboshko

Vikhnina

Savenko

2016

Vestn. otorinolaringol.

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Intrauterine infections are a crucial pathogenic factor exerting an appreciable influence on the development of the fetus. They can provoke intrauterine death, cause multiple lesions in the organs and tissues as well as long-term complications that manifest themselves at the later stages of the growth and development of the child. One of such complications is the sensorineural loss of hearing. The importance of hearing impairment arises from the high prevalence of tis condition and frequent incapacitation it causes in the patients. The present publication is focused on various mechanisms underlying the development of hearing impairment depending on the primary infection. Special attention is given to the methods of diagnostics and treatment of intrauterine infections.

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Treatment of Late-Onset Hearing Loss in Infants With Congenital Cytomegalovirus Infection

Abstract: In children with late-onset hearing loss due to cytomegalovirus infection, antiviral treatment appears to prevent further deterioration and produce improvement. Controlled studies are needed to verify this observation.

Cited by 31 publications

References 15 publications

The modern view of congenital cytomegalovirus infection: diagnosis, treatment and prevention

The modern view of congenital cytomegalovirus infection: diagnosis, treatment and prevention

Potential Benefit of Selective CMV Testing after Failed Newborn Hearing Screening

Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing

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