Treatment of Keloids with Hyaluronidase

Hyaluronidase

“…24 Hyaluronidase has also been used to manage lymphedema and keloids. [32][33][34][35] Lymphedema of the upper and lower extremities in five patients was successfully treated with hyaluronidase when administered using iontophoresis. 32 This treatment reduced limb swelling by increasing skin and subcutaneous tissue fluid absorption.…”

“…For keloids, one study involving 26 patients using preoperative hyaluronidase and excisional surgery followed by external radiation resulted in no recurrence; in contrast, radiation after excisional surgery without preoperative hyaluronidase resulted in 21% recurrence after 1 year. 33,34 An alternative treatment for keloids is intralesional corticosteroid injection; the difficulty of injecting into this hard mass can be overcome by softening the lesion with the addition of hyaluronidase. 35 A 16% recurrence rate of keloid in 37 patients 3 years after treatment with carbon dioxide ablative laser and after hyaluronidase has been reported, whereas that from ablation using carbon dioxide alone ranged from 39% to 92%.…”

Treatment of Keloid with Asiaticoside

“…This gives the drug an ad vantage over steroids which when injected intralesionally in keloids, the escape of the drug into the surrounding tissue m ay result in dis figuring cutaneous, subcutaneous and possibly muscular atrophy, as was stated by Asboe-Hansen [4]. Good results from intralesional in jections of hyaluronidase are claimed by Cornbleet [5], although AsboeHansen [4] stated th at repeated hyaluronidase injections m ay bring about flattening but bear the risk of secondary regrowth as an overcom pensatory new production of hyaluronic acid.…”

“…Cornbleel [5] (1954) claims good results from hyaluronidase intralesional injec tions even in cases that failed with surgical repair and radiotherapy.…”

Pilot Study Evaluating Topical Onion Extract as Treatment for Postsurgical Scars

“…5 Systemic pharmacologic treatments, which act using one of these proposed mechanisms of action, include colchicine, 6 D-penicillamine, antihistamines, 7 intralesional steroids, 8 and intralesional hyaluronidase. 9 Topical treatments include retinoic acid, 10 steroids, 7 vitamin E, 11 silicone gel sheeting, 12 cryotherapy, 13 and pressure dressings. 3 The most recent addition in the armamentarium of scar treatment is MEDERMA (Contractubex, Merz, Frankfurt, Germany), which is a topical gel containing allium cepa (onion extract) as the active ingredient.…”