Pilot Study Evaluating Topical Onion Extract as Treatment for Postsurgical Scars

Jackson, Brooke A.; Shelton, Andrea J.

doi:10.1046/j.1524-4725.1999.08240.x

Cited by 70 publications

(40 citation statements)

References 15 publications

(18 reference statements)

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“…The combined effects of the CAH mixture show time-related differences. The drug reduces inflammation and fibroblast proliferation in the first stage and decreases the accumulation of connective tissue elements such as proteoglycans and collagen in the terminal stages of the wound healing process (21,23). It has therefore been used for many years to achieve a hypertrophic scar-free wound healing process (21,24).…”

Section: Discussionmentioning

confidence: 99%

Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model

et al. 2016

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“…21 However, limited clinical trials have failed to demonstrate any clinical improvement in scar height or erythema. 22 Products containing onion extracts did not provide any additional improvement in scar cosmesis than a petrolatum-based ointment. 23 Hosnuter et al 24 evaluated the therapeutic activity of topical onion extract in gel form to treat hypertrophic scars and keloids.…”

Section: Onion Extractmentioning

confidence: 92%

Scar Revision Review

Thomas

Somenek

2012

Arch Facial Plast Surg

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Scars are a natural part of dermal healing following lacerations, incisions, or tissue loss. They can vary in quality depending on the individual's racial characteristics, the mechanism of the trauma, and conditions in which the wound healed-all of which are factors beyond the surgeon's control. A scar on the face can have significant implications for the patient. What may seem like an insignificant issue to the casual observer can cause continuous frustration for the patient, affecting their daily lives. These can include psychological as well as social consequences, leading to a diminished quality of life. Factors that the surgeon can control include the favorable repositioning of the scar, proper alignment of the wound edges, and meticulous handling of the tissues.

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“…106 There was also no benefit seen with Mederma in a trial involving human patients following Mohs microsurgery. 107 The drug imiquimod modulates the inflammatory response in wound healing and stimulates interferon activity. 101 Several noncontrolled studies evaluated the use of imiquimod cream after surgical excision of keloids and reported a wide range of recurrence rates (0-100%).…”

Section: Stem Cells In 2009 Biernaskie Et Al Deter-mentioning

confidence: 99%

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Marshall

Leavitt

et al. 2018

Advances in Wound Care

220

176

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Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar. SCOPE AND SIGNIFICANCEThis review begins with an overview of how human skin wounds heal, with an emphasis on the formation of scar as the end result of wound healing. This is followed by a review of recent developments in the cellular biology of wound healing and scarring, particularly related to stem cells and fibroblasts. Finally, traditional and novel treatments intended to prevent and reduce scarring are described. This review will be of interest to clinicians and basic scientists who wish to better understand the processes of wound healing and scarring as well as the treatment options available. TRANSLATIONAL RELEVANCEA great deal has been learned about the cellular and molecular pathways that contribute to scar formation. At the same time, clinicians have understood for centuries that certain techniques allow wounds to heal faster with less scarring. Despite the enormity of the clinical problem presented by scarring, there has been a failure to translate the basic science of scarring into improved scarring treatments that take advantage of specific molecular and cellular targets. However, in the field, there is optimism that recent advances will bridge the gap between the basic science and the clinical treatment of scarring. CLINICAL RELEVANCE Scarring of the skin affects millions of patients and in some, particularly children and burn victims, causes a great deal of suffering. Scar prevention mainly consists of the principles of wound closure without tension and avoiding infection and wound breakdown. Various treatments for established scars exist, with varying levels of effectiveness. Burn scars are particularly challenging, and treatment is largely supportive with the option for revision surgery to remove scarred skin. A novel drug-based treatment that makes use of a specific mole...

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Pilot Study Evaluating Topical Onion Extract as Treatment for Postsurgical Scars

Abstract: Scar hydration is an important factor in wound healing and can be achieved with topical petrolatum-based ointment. Topical onion gel extract was ineffective in improving scar erythema and pruritus in our patients.

Cited by 70 publications

References 15 publications

Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model

Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model

Scar Revision Review

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

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