Treatment of keloids and hypertrophic scars using bleomycin

Aggarwal, Himanshu; Saxena, Anurag; Lubana, Parvinder; Mathur, Rajkumar; Jain, DK

doi:10.1111/j.1473-2165.2008.00360.x

Cited by 61 publications

(53 citation statements)

References 21 publications

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“…This resulted in complete flattening in 22 patients (44%), significant flattening in 11 patients (22%), adequate flattening in 7 patients (14%) and no flattening in 10 patients (20%). The difference between the present study and that of Aggarwal et al (2008) may be due to the difference in the methods of injection. It could be concluded that intralesional injection of bleomycin is more effective than the superficial puncture techniques.…”

Section: Espana Et Al (2001) Used Intralesional Bleomycin Injection contrasting

confidence: 54%

“…Complete flattening was seen in 6 patients, highly significant flattening (>90%) was observed in 6 patients, and significant flattening (75%-90%) in 1 patients. Also, Aggarwal et al (2008) used bleomycin by multiple superficial puncture technique to treat fifty patients with keloids and hypertrophic scars. Three applications were given at interval of fifteen days followed by a fourth and final application two months after the last application.…”

Section: Espana Et Al (2001) Used Intralesional Bleomycin Injection mentioning

confidence: 99%

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Comparative study between intralesional injection of bleomycin and 5-fluorouracil in the treatment of keloids and hypertrophic scars

Kabel

Sabry

Sorour

et al. 2016

Journal of Dermatology & Dermatologic Surgery

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Section: Espana Et Al (2001) Used Intralesional Bleomycin Injection contrasting

confidence: 54%

Section: Espana Et Al (2001) Used Intralesional Bleomycin Injection mentioning

confidence: 99%

Comparative study between intralesional injection of bleomycin and 5-fluorouracil in the treatment of keloids and hypertrophic scars

Kabel

Sabry

Sorour

et al. 2016

Journal of Dermatology & Dermatologic Surgery

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“…Ulceration healed within 10 days and hyperpigmentation resolved after 1 year of follow up. 44,45 None of the patients demonstrated any pulmonary, hepatic, or other major sideeffect of bleomycin, which may due to low dose of this drug. The recurrence reported by Himanshu was about 14% over 18 months of follow-up, which is similar to results shown by Espana (15.4%).…”

Section: Bleomycin Injectionmentioning

confidence: 97%

A Review of the Effectiveness of Antimitotic Drug Injections for Hypertrophic Scars and Keloids

Wang

Liu²,

Qing³

et al. 2009

Annals of Plastic Surgery

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Hypertrophic scars and keloids are common problems after injury and cause functional and cosmetic deformities. A wide variety of treatments have been advocated for hypertrophic scars and keloids regression. Unfortunately, the reported efficacy has been variable. This article explores antimitotic drugs described in the literature such as steroid injection, 5-FU, mitomycin C, and bleomycin, which mainly target the fibroblasts in scar tissue, have been proposed as the effective modalities for scar treatment and scar prevention after surgery, but restricted due to possible side effects. The current accepted treatment for hypertrophic scar and keloid are combination therapy and the early treatment which could achieve better efficacy and less adverse effect.

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“…Injected bleomycin was effective at causing flattening of keloid scars in two noncontrolled studies. 126,127 Pressure therapy. Pressure garments are a commonly used conservative therapeutic option for scars and are particularly popular for large burn scars.…”

Section: Stem Cells In 2009 Biernaskie Et Al Deter-mentioning

confidence: 99%

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Marshall

Leavitt

et al. 2018

Advances in Wound Care

221

176

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Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar. SCOPE AND SIGNIFICANCEThis review begins with an overview of how human skin wounds heal, with an emphasis on the formation of scar as the end result of wound healing. This is followed by a review of recent developments in the cellular biology of wound healing and scarring, particularly related to stem cells and fibroblasts. Finally, traditional and novel treatments intended to prevent and reduce scarring are described. This review will be of interest to clinicians and basic scientists who wish to better understand the processes of wound healing and scarring as well as the treatment options available. TRANSLATIONAL RELEVANCEA great deal has been learned about the cellular and molecular pathways that contribute to scar formation. At the same time, clinicians have understood for centuries that certain techniques allow wounds to heal faster with less scarring. Despite the enormity of the clinical problem presented by scarring, there has been a failure to translate the basic science of scarring into improved scarring treatments that take advantage of specific molecular and cellular targets. However, in the field, there is optimism that recent advances will bridge the gap between the basic science and the clinical treatment of scarring. CLINICAL RELEVANCE Scarring of the skin affects millions of patients and in some, particularly children and burn victims, causes a great deal of suffering. Scar prevention mainly consists of the principles of wound closure without tension and avoiding infection and wound breakdown. Various treatments for established scars exist, with varying levels of effectiveness. Burn scars are particularly challenging, and treatment is largely supportive with the option for revision surgery to remove scarred skin. A novel drug-based treatment that makes use of a specific mole...

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Treatment of keloids and hypertrophic scars using bleomycin

Abstract: Bleomycin is easy to administer, is cheap, shows high regression rate, and has minimum complication and recurrence. Thus, it can be used as the first-line treatment modality for management of keloids and hypertrophic scars.

Cited by 61 publications

References 21 publications

Comparative study between intralesional injection of bleomycin and 5-fluorouracil in the treatment of keloids and hypertrophic scars

Comparative study between intralesional injection of bleomycin and 5-fluorouracil in the treatment of keloids and hypertrophic scars

A Review of the Effectiveness of Antimitotic Drug Injections for Hypertrophic Scars and Keloids

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

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