Treatment of Keloids: A Meta-analysis of Intralesional Triamcinolone, Verapamil, and Their Combination

Abstract

They can occur in many places on the body; however, the chest, shoulders, and earlobes are the most common locations. 1 Although there are many treatment modalities in use, none have been determined to be the gold standard of care. Keloid therapy continues to be an emphasized area of research to attempt to find the best treatment possible. There have been numerous treatment modalities attempted in the clinical setting, ranging from noninvasive to surgical. These include pressure dressings, silicone gel sheeting, intralesional medications (corticosteroids, verapamil, bleomycin, 5-fluorouracil), topical mitomycin C, radiotherapy, cryotherapy, and excision. 2

Surgical excision and skin grafting combined with intralesional injection of triamcinolone for the treatment of keloids after syndactyly release

“…Triamcinolone acetonide has become a wellestablished anti-keloid corticosteroid with low systematic toxicity since it was reported by Griffith (1966). It is an effective anti-inflammatory agent that decreases fibroblast proliferation and collagen synthesis (Klomparens and Simman, 2022). Lim et al (2007) reported keloid formation in four patients after syndactyly reconstruction with an acceptable result after two intralesional triamcinolone acetonide injections.…”

“…Drug injection has always been a major adjuvant therapy. The commonly used keloid injection drugs include corticosteroids (triamcinolone acetonide and betamethasone), 5fluorouracil, verapamil and bleomycin (Kim et al, 2020;Klomparens and Simman, 2022;Sun et al, 2021). Successful outcomes after methotrexate administration have also been reported, although close monitoring is required because of the various systematic side effects of this drug (Kong et al, 2012;Muzaffar et al, 2004;Tolerton and Tonkin, 2011;Tonkin et al, 2008;Widerberg and Rosberg, 2019).…”

“…Triamcinolone acetonide has become a well-established anti-keloid corticosteroid with low systematic toxicity since it was reported by Griffith (1966). It is an effective anti-inflammatory agent that decreases fibroblast proliferation and collagen synthesis (Klomparens and Simman, 2022). Lim et al.…”

“…Triamcinolone acetonide has proven effective in managing keloid and is commonly considered to be the first-line therapy (Griffith, 1966; Klomparens and Simman, 2022; Ren et al., 2017). Two studies have reported acceptable results for simple triamcinolone acetonide injection in six mild cases of keloids after syndactyly reconstruction (Langlais et al., 2022; Lim et al., 2007).…”

Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial

“…These include dressings, silicone gel sheeting, intralesional injections, topical application of mitomycin C, radiotherapy, cryotherapy, and surgical excision. 3 Considering the high likelihood of recurrence following keloid excision, the medical field is extensively exploring various treatment options to discover the most effective intervention. 4 Corticosteroids, notably triamcinolone, are typically the initial choice in the treatment of keloids.…”