Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial

Abstract

IntroductionIn this clinical trial, we investigated the efficacy of two treatment methods for keloids resulting from surgical incisions: intralesional triamcinolone injections alone versus in combination with verapamil.Material and MethodsPatients were divided into two groups: one received triamcinolone alone (Group T) and the other received a triamcinolone‐verapamil blend (Group VT). Regular treatments were conducted until the keloids were nearly flat or for a maximum of eight sessions.ResultsBoth groups showed significant improvements, but Group VT saw quicker resolution of skin redness and needed fewer sessions. Though the Vancouver Scar Scale (VSS) scores were generally similar across both groups, Group VT exhibited greater improvements, leading to lower final scores. The VT group also attained normal scar flexibility faster than the T group.ConclusionThese findings suggest that the combination of verapamil and triamcinolone provides a more effective treatment for keloids, thereby highlighting the potential of verapamil in scar reduction.

Effects of miR-214 on adenosine A2A receptor and carboxymethyl chitosan nanoparticles on the function of keloid fibroblasts and their mechanisms

“…All collected scar tissue was confirmed by the pathology department. The diagnostic criteria for scar tissue were as follows 21 : fibroblasts in the scar tissue exhibit a ruptured appearance, irregular arrangement, abundant mucoid interstitium, and more hyaluronic acid in the epidermis. The inclusion criteria for scar tissue are: (1) a disease course of more than nine months without spontaneous acute regression; (2) recurrence after surgical or other treatment; and (3) skin damage exceeding the initial injury site and invading surrounding skin.…”

Pharmacotherapy for Keloids and Hypertrophic Scars

“…A combination of two drugs can augment their mechanisms without unwanted side effects [431]. The combination of TAC and VER incorporated in hydroxypropyl β-cyclodextrin (HP-β-CD) microneedles significantly decreases the thickness of HTSs, as well as hydroxyproline (HYP) and TGF-β1 expression in HTSs, and it improves collagen fiber arrangement and reduces dermis congestion and hyperplasia [432]. The clinical efficacy of intralesional triamcinolone alone and a combination of triamcinolone and VER was compared in KD patients.…”