Treatment of intrabony defects with beta‐tricalciumphosphate alone and in combination with platelet‐rich plasma

Abstract

Background:The therapeutic efficacy of platelet‐rich plasma (PRP) still remains controversial. This study aimed to compare the efficacy of a beta‐tricalcium phosphate (β‐TCP) and PRP/β‐TCP combination both clinically and radiographically.Methods:Fourteen chronic periodontitis patients with at least two similar three‐walled defects were included in the study. Each patient was randomly treated with both β‐TCP (n = 14) and PRP/β‐TCP (n = 14) in the same session. Baseline and 6‐month evaluations of plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), gingival recession (GR), bleeding on probing, and radiographic intrabony defect depth (RIDD) were assessed statistically.Results:At 6 months, statistically significant reductions of GI, PPD, BOP, and RIDD were observed in both groups. The median values of CAL decreased from 7.0 to 6.0 mm in the β‐TCP group (p = 0.002), and 7.5 to 5.0 mm in the PRP/β‐TCP group (p < 0.001). No statistically significant difference was detected between the two groups for all clinical indices.Conclusion:After a 6‐month healing period, both β‐TCP and PRP/β‐TCP were found effective in the treatment of three‐walled intrabony defects and no additional statistically significant benefits were found with PRP. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.

Guided bone regeneration in standardized calvarial defects using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats

“…The volumetric results of the present study are in line with previously reported studies using b-TCP for GBR [16,18,34,35]. Brkovic et al [14] reported that placement of b-TCP along with collagen membrane in extraction sockets resulted in good-quality healed bone which was capable of supporting implants.…”

Comparative evaluation of clinical efficacy of β-tri calcium phosphate (Septodont-RTR) TM alone and in combination with platelet rich plasma for treatment of intrabony defects in chronic periodontitis

“…These results are concomitant with earlier studies. [1920] This could be because of the regular and frequent recall visits in which the patients underwent regular supragingival scaling, which further minimized plaque accumulation.…”

Cranial vault reconstruction with bone morphogenetic protein, calcium phosphate, acellular dermal matrix, and calcium alginate in mice

“…It is commercially available as blocks or granules. There are several papers combining TCP to GF, with positive and negative results 40,44 . Afifi et al 45 have demonstrated that TCP alone has a non-negligible tax of complications in cranioplasties, especially when inserted in previously irradiated areas, or for those in contact with paranasal sinuses.…”