Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral <i>vs</i> intramuscular; an open labeled <scp>RCT</scp>

Zabihiyeganeh, Mozhdeh; Jahed, Seyed Adel; Nojomi, Marzieh

doi:10.1111/j.1365-2265.2012.04518.x

Cited by 33 publications

(26 citation statements)

References 32 publications

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“…Other studies also found that accumulative doses of 1 00 000-1 20 000 IU/month were insufficient to raise serum-25(OH)D concentrations to ⩾ 75 nmol/l. 6,40 The study by Zabihiyeganeh et al, 6 showed that among Iranians (serum-25(OH)D o 75 nmol/l), 65.6% of the patients who received accumulative dose of 300 000 IU over 3 months reached serum-25(OH)D concentration ⩾ 75 nmol/l after 6 months, 6 a finding comparable to ours (66.7%). So, larger doses than monthly 1 00 000 IU are required to shift vitamin D status to ⩾ 75 nmol/l in the populations with high prevalence of vitamin D insufficiency.…”

Section: Discussionsupporting

confidence: 85%

“…2 Concurrently, vitamin D deficiency/insufficiency is re-emerging as a worldwide public health issue. 3 Evidence shows that Middle Eastern women living in their home country [4][5][6] or in other countries as immigrants [7][8][9] have low serum-25(OH)D concentrations. Comparable to Turkish women, 45.0% of Iranian women living in Oslo, Norway, had serum levels o20 nmol/l.…”

Section: Introductionmentioning

confidence: 98%

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The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

2014

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 98%

The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

2014

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“…Peak levels of 25OHD were seen at 30 and 120 days in those given oral and IM treatment, respectively. Another study in 92 adults with 25OHD <75 nmol/l compared 300,000 IU vitamin D 3 IM to 50,000 IU D 3 orally given on 6 occasions over 3 months [71] . A higher proportion of subjects receiving oral treatment had 25OHD >75 nmol/l at 3 and 6 months than IM subjects.…”

Section: Evidencementioning

confidence: 99%

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Munns¹,

Shaw²,

Kiely³

et al. 2016

Horm Res Paediatr

353

477

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Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, and development of infants, children, and adolescents; the consequences can be lethal or can last into adulthood. The goals of this evidence-based consensus document are to provide health care professionals with guidance for prevention, diagnosis, and management of nutritional rickets and to provide policy makers with a framework to work toward its eradication. Evidence: A systematic literature search examining the definition, diagnosis, treatment, and prevention of nutritional rickets in children was conducted. Evidence-based recommendations were developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system that describes the strength of the recommendation and the quality of supporting evidence. Process: Thirty-three nominated experts in pediatric endocrinology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. nology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. Key WordsRickets · Nutrition · Vitamin D · Calcium · Consensus recommendations Abstract Background: Vitamin D and ca...

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“…demonstrated that considerable efficacy and safety of two different oral and injectable regimens utilizing a total dose of 300,000-IU Vitamin D3 in treating hypovitaminosis D.[18] They concluded that in the short-term oral preparations are effective in correction of Vitamin D deficiency. In our study too, the serum 25OHD levels at 6 weeks were comparable in the oral and IM D3 group.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency

Gupta

Farooqui

Batra

et al. 2017

Indian J Endocr Metab

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Context:A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency.Aims:The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital.Settings and Design:Prospective randomized open-label single institution study.Subjects and Methods:This study enrolled 40 apparently healthy adults with Vitamin D deficiency into 2 arms. The oral cholecalciferol group (n = 20) received oral cholecalciferol 60,000 IU weekly for 5 weeks while the IM cholecalciferol group (n = 20) received a single injection of cholecalciferol 300,000 IU. The main outcome measure was serum 25-hydroxyvitamin D (25OHD) levels at baseline, 6 and 12 weeks after the intervention.Statistical Analysis Used:Differences in serum 25OHD and other biochemical parameters at baseline and follow-up were analyzed using general linear model.Results:Mean 25OHD level at baseline was 5.99 ± 1.07 ng/mL and 7.40 ± 1.13 ng/mL (P = 0.332) in the oral cholecalciferol and IM cholecalciferol group, respectively. In the oral cholecalciferol group, serum 25OHD level was 20.20 ± 1.65 ng/mL at 6 weeks and 16.66 ± 1.36 ng/mL at 12 weeks. The corresponding serum 25OHD levels in the IM cholecalciferol group were 20.74 ± 1.81 ng/mL and 25.46 ± 1.37 ng/mL at 6 and 12 weeks, respectively. At 12 weeks, the mean 25OHD levels in IM cholecalciferol group was higher as compared to the oral cholecalciferol group (25.46 ± 1.37 vs. 16.66 ± 1.36 ng/mL; P < 0.001).Conclusions:Both oral and IM routes are effective for the treatment of Vitamin D deficiency. 25-hydroxyvitamin D levels in the IM cholecalciferol group showed a sustained increase from baseline.

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Treatment of hypovitaminosis D with pharmacologic doses of cholecalciferol, oral vs intramuscular; an open labeled RCT

Cited by 33 publications

References 32 publications

The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency

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