The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

Mazahery, Hajar; Stonehouse, Welma; Hurst, Pamela von

doi:10.1038/ejcn.2014.264

Cited by 25 publications

(35 citation statements)

References 44 publications

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“…Many studies conclude that vitamin D deficiency is common in middle Eastern female immigrants but that their response to prescribed vitamin D dosages is often inadequate [28]. …”

Section: Discussionmentioning

confidence: 99%

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

Kalliokoski

Rodhe

Bergqvist

et al. 2016

BMC Pregnancy Childbirth

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BackgroundMuscular weakness and severe vitamin D deficiency is prevalent in Somali (veiled) pregnant women, Sweden. The study aims here were to explore adherence to prescribed supplemental vitamin D in new mothers with vitamin D deficiency and its effects on grip strength and upper leg performance in Somali (target group TG) and Swedish women (reference group RG) from spring through winter.MethodsA before- and after study was designed. A cross-sectional sample of women in antenatal care with serum 25-OHD ≤50 nmol/L were prescribed one or two tablets daily (800 or 1600 IU vitamin D3 with calcium) for 10 months. Reminders were made by Somali nurses (TG) or Swedish doctors (RG). Baseline and 10 month measurements of plasma nmol/L 25-OHD, maximal grip strength held for 10 s (Newton, N) and ability to squat (yes;no) were done. Total tablet intake (n) was calculated. Outcome variables were changes from baseline in grip strength and ability to squat. Predicting variables for change in grip strength and ability to squat were calculated using linear and binary regression in final models. Undetectable 25-OHD values (<10 nmol/L) were replaced with ‘9’ in statistic calculations.ResultsSeventy-one women (46 TG, 1/3 with undetectable baseline 25-OHD; 25 RG) participated. At the 10-month follow up, 17% TG and 8% RG women reported having refrained from supplement. Mean 25-OHD increased 16 to 49 nmol/L (TG) and 39 nmol/L to 67 nmol/L (RG), (both p < 0.001). Grip strength had improved from 153 to 188 N (TG) (p < 0.001) and from 257 to 297 N (RG) (p = 0.003) and inability to squat had decreased in TG (35 to 9, p < 0.001). Intake of number of tablets predicted increased grip strength (B 0.067, 95%CI 0.008–0.127, p = 0.027). One tablet daily (>300 in total) predicted improved ability to squat (OR 16; 95% CI 1.8–144.6).ConclusionsAdherence to supplemental vitamin D and calcium should be encouraged as an even moderate intake was associated to improved grip strength and upper leg performance, which was particularly useful for the women with severe 25-OHD deficiency and poor physical performance at baseline.Trial registrationClinicalTrials.gov Identifier: NCT02922803. Date of registration: September 28, 2016.

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“…Many studies conclude that vitamin D deficiency is common in middle Eastern female immigrants but that their response to prescribed vitamin D dosages is often inadequate [28]. …”

Section: Discussionmentioning

confidence: 99%

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

Kalliokoski

Rodhe

Bergqvist

et al. 2016

BMC Pregnancy Childbirth

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“…Baseline 25(OH)D amounts accounted 20.2% of the differences in feedback to supplementation in premenopausal Middle Eastern woman. 8 The present model indicates that WHR is associated with the response to VitD supplementation, although it is not at the apex of the tree. Ekwaru et al through statistical results reported that BMI is the better factor against absolute body weight to identify VitD doses is required for specific body weight groups.…”

Section: Discussionmentioning

confidence: 66%

“…Overweight subjects appeared almost 1.5 times more in comparison with normal weight subjects . There is correlation between high body fat percentage or BMI or WC with lower increases in 25(OH)D levels in response to supplementation . The mechanism of which adipose tissue affects circulating 25(OH)D response to VitD supplementation is that VitD is a fat soluble vitamin and is stored in regions of body fat for subsequent use .…”

Section: Discussionmentioning

confidence: 98%

“…Hepatic hydroxylation of VitD may be a saturable process, so response to VitD supplementation could entirely be affected by baseline 25(OH)D levels. Baseline 25(OH)D amounts accounted 20.2% of the differences in feedback to supplementation in premenopausal Middle Eastern woman …”

Section: Discussionmentioning

confidence: 99%

“…However, in response to an administration dose of VitD supplement, the increase in 25(OH)D level is different between individuals . Due to the broad inter‐individual differences, the one‐size‐fits‐all strategy has not been effected by supplementation . In giving recommendations about VitD supplementation to the general public, it is therefore important for clinicians to know factors affecting the amount of response to supplements to apply individualization treatment approach.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of the magnitude of response to vitamin D supplementation in adolescent girls identified using a decision tree algorithm

et al. 2019

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Vitamin D (VitD) supplementation is an inexpensive and effective approach for improving VitD insufficiency/deficiency. However, the response to supplementation, with respect to the increase in serum 25(OH)D level varies between individuals. In this study, we have assessed the factors associated with the response to VitD supplementation using a decision‐tree algorithm. Serum VitD levels, pre‐ and post‐VitD supplementation was used as the determinant of responsiveness. The model was validated by constructing a receiver operating characteristic curve. Serum VitD at baseline levels was at the apex of the tree in our model, followed by serum low‐density lipoprotein cholesterol and triglyceride, age, waist‐hip ratio, and high‐density lipoprotein cholesterol. Our model suggests that these determinants of responsiveness to VitD supplementation had sensitivity, specificity, and accuracy, 59.4, 75.8 and 69.3%, respectively. The decision tree model appears to be a relatively accurate, specific, and sensitive approach for identifying the factors associated with response to VitD supplementation.

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Factors determining the serum 25‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach

et al. 2021

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Vitamin D supplementation has been shown to prevent vitamin D deficiency, but various factors can affect the response to supplementation. Data mining is a statistical method for pulling out information from large databases. We aimed to evaluate the factors influencing serum 25-hydroxyvitamin D levels in response to supplementation of vitamin D using a random forest (RF) model. Data were extracted from the survey of ultraviolet intake by nutritional approach study. Vitamin D levels were measured at baseline and at the end of study to evaluate the responsiveness. We examined the relationship between 76 potential influencing factors on vitamin D response using RF. We found several features that were highly correlated to the serum vitamin D response to supplementation by RF including anthropometric factors (body mass index [BMI], free fat mass [FFM], fat percentage, waist-to-hip ratio [WHR]), liver function tests (serum gamma-glutamyl transferase [GGT], total bilirubin, total protein), hematological parameters (mean corpuscular volume [MCV], mean corpuscular hemoglobin concentration [MCHC], hematocrit), and measurement of insulin sensitivity (homeostatic model assessment of insulin resistance). BMI, total bilirubin, FFM, and GGT were found to have a positive relationship and homeostatic model assessment for insulin resistance, MCV, MCHC, fat percentage, total protein, and WHR were found to have a negative correlation to vitamin D concentration in response to supplementation. The accuracy of RF in predicting the response was 93% compared to logistic

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The effect of monthly 50 000 IU or 100 000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland

Abstract: Vitamin D deficiency/insufficiency is highly prevalent in this population. Monthly 100,000 IU vitamin D for 6 months is more effective than 50,000 IU in achieving serum-25(OH)D ⩾75 nmol/l; however, a third of women still did not achieve these levels.

Cited by 25 publications

References 44 publications

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

Determinants of the magnitude of response to vitamin D supplementation in adolescent girls identified using a decision tree algorithm

Factors determining the serum 25‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach

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