Treatment of Gram-negative septic shock with an immunoglobulin preparation

Schedel, I.; Dreikhausen, Ursula; Nentwig, B.; Höckenschnieder, Marion; Rauthmann, D.; Balikcioglu, S.; Coldewey, R.; Deicher, H.

doi:10.1097/00003246-199109000-00003

Cited by 224 publications

(58 citation statements)

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“…Stehr et al (26) emphasized the benefits of polyclonal IgM-enriched solution by using a rabbit model of bacteremia. Clinical trials showed that IgM-enriched preparations were able to significantly decrease endotoxin levels in plasma (23) and even reduce mortality (22) during the early phase of septic shock. Norrby-Teglund et al (47) showed that IgM-enriched Immune complexes between bacteria and human plasma-derived pIgA, SIgA, mIgA, IgG, IgM, SigM, or anti-Shigella LPS-specific SIgAC5 monoclonal Ab were formed for 1 h as described under "Experimental procedures," and the expression of virulence factors was induced by Congo red.…”

Section: Discussionmentioning

confidence: 99%

“…Preclinical and clinical studies have underscored the efficacy against various infectious agents of polyclonal IgM-enriched preparations administered by the systemic route (22)(23)(24)(25)(26). Similar to SIgA, SIgM can be seen as a valid candidate immunoglobulin for mucosal application, given its ability to bind antigens with strong avidity, its potential to ensure long term protection (27), its capacity to survive low pH conditions (28), as well as its resistance to proteases (29).…”

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confidence: 99%

See 1 more Smart Citation

Reconstituted Human Polyclonal Plasma-derived Secretory-like IgM and IgA Maintain the Barrier Function of Epithelial Cells Infected with an Enteropathogen

Longet

Vonarburg

Lötscher

et al. 2014

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Reconstituted Human Polyclonal Plasma-derived Secretory-like IgM and IgA Maintain the Barrier Function of Epithelial Cells Infected with an Enteropathogen

Longet

Vonarburg

Lötscher

et al. 2014

Journal of Biological Chemistry

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“…[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] The studies included in our review were very similar to those in the recently updated Cochrane review; 15 however, Just et al 40 was omitted and Spannbrucker et al 49 included.…”

Section: Literature Searching/inclusion Criteriamentioning

confidence: 99%

“…The data extracted from the 17 included studies [42][43][44][45][46][47][48][49][50][51][52][53][54][55] are summarised in Tables 7-13. 42,[48][49][50][52][53][54][55] out of the 17 studies (47%) explicitly reported that they were carried out in a critical-care unit setting; however, our assessment of the patient characteristics for inclusion in the other studies indicated a population with severe sepsis in each case, and so it was inferred that these studies would have been conducted in a critical-care unit setting.…”

Section: Data Extractionmentioning

confidence: 99%

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis.

Soares

Welton²,

Harrison³

et al. 2012

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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“…But our results showed no significant clinical effect in short term prognosis. On the other hand, previous studies from overseas have used even higher doses [15][16][17][18][19][20][21][22][23][24] than that used in this study, and there may also be a need to conduct analyses in Japan using these higher doses on prognosis of severe sepsis and septic shock.…”

Section: Discussionmentioning

confidence: 97%

Effect of High-Dose Intravenous Immunoglobulin Administration on the Levels of Interleukin-6 in Patients with Sepsis

Kusunoki¹,

Nishi²,

Umegaki³

et al. 2017

Intensive & Crit Care

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Treatment of Gram-negative septic shock with an immunoglobulin preparation

Cited by 224 publications

References 0 publications

Reconstituted Human Polyclonal Plasma-derived Secretory-like IgM and IgA Maintain the Barrier Function of Epithelial Cells Infected with an Enteropathogen

Reconstituted Human Polyclonal Plasma-derived Secretory-like IgM and IgA Maintain the Barrier Function of Epithelial Cells Infected with an Enteropathogen

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis.

Effect of High-Dose Intravenous Immunoglobulin Administration on the Levels of Interleukin-6 in Patients with Sepsis

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