Treatment of gonorrhoea with single oral doses of ampicillin plus probenecid. I. Comparison with procaine penicillin.

Diagnostic treatment and reporting criteria for gonorrhoea in sexually transmitted disease clinics in England and Wales. 2: treatment and reporting criteria.

“…Gundersen et al (1969) was the first person to tackle this problem and showed that a combination of 2 g of ampicillin plus 1 g of probenecid given once gave a failure rate of only 1-2%. The final step in the acceptance of ampicillin was in studies that showed that 2 g of ampicillin plus probenecid was as effective as 1-2 megaunits of procaine penicillin plus probenecid Willcox et al, 1973). Many of these series are not comparable as different follow-up intervals are used after treatment, criteria of treatment failure vary, and information on penicillin sensitivities of the gonococci is not always available.…”

Oral talampicillin in the treatment of gonorrhoea.

“…The use of single dose antibiotic therapy for the treatment of acute uncomplicated gonorrhoea has been the subject of previous research (Kvale et al, 1971;Masterton and Schofield, 1972;Willcox et al, 1973). This type of treatment results in the eradication of the gonococcus in 98 % of cases in both sexes (Gundersen et al, 1969;Kvale et al, 1971).…”

“…In 1961, with the advent of ampicillin, a valuable oral therapy was introduced. This semi-synthetic penicillin has now become recognised worldwide as standard oral treatment and single dose administration is recommended by the Venereal Disease Control Division, Center for Disease Control, Atlanta, USA (Center for Disease Control, 1972, 1974 and also by the clinics in the United Kingdom, where it is often given with probenecid (Willcox et al, 1973).…”

Single-dose treatment of gonorrhoea with cotrimoxazole. A report on 1,223 cases.

“…clinics as it facilitates handling of patients, requires rather less care and attention, and is particularly convenient in small clinics although it would not be preferred by all patients, especially immigrants. Parenteral penicillin remains the drug of choice in the treatment of gonorrhoea, but oral penicillins have yet to prove their effectiveness when given a single dose (Gundersen, Odegaard, and Gjessing, 1969;Alergant, 1973;Willcox, Woodcock, Latto, John, Redmond, Parker, Rees, Cobbold, 1973).…”