Treatment of giant cell granuloma of the maxilla with intralesional injection of steroids

A 10‐year review of the occurrence and treatment of central giant cell granulomas, in a District General Hospital

“…Successful non-surgical treatment with intralesional corticosteroid injections has been advocated in a variety of cases (18,24,30,31,42,43). Steroids, such as triamcinolone acetonide, inhibit osteoclasts in marrow cultures and in conditions of resorption of bone by increased apoptosis (31).…”

Central giant cell granuloma in anterior maxilla

“…6 Central GCG (e.g., GCG of the mandible and maxilla) is less common than peripheral GCG of the extremities. 7 GCG affects children and adults, and may occur at any age, but is most commonly seen in the first 3 decades. It is more frequent in females than in males.…”

Giant cell granuloma of the maxilla. Global management, review of literature and case report.

“…So basically include three lines of conservative treatment. The most used is the intralesional injection of corticosteroids, with different guidelines and protocols, of which the most widespread in the literature is the weekly injection of triamcinolone (7) associated with local anesthetic for a period six weeks. Other conservative options are the use of calcitonin (8) (usually in the form of nasal spray) or interferon-α (INF-α) (4,8), both in pattern of several months, depending on the success in reducing the granuloma.…”