Treatment of gallbladder cancer by radical resection

Todoroki, Takeshi; Kawamoto, Toru; Takahashi, Hideto; Takada, Yasutsugu; Koike, Naoto; Otsuka, Masaaki; Fukao, Katashi

doi:10.1046/j.1365-2168.1999.01085.x

Cited by 126 publications

(121 citation statements)

References 8 publications

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“…More and more people advocated extended radical cholecystectomy in patients of medium and advanced stage in order to improve the long-term survival. Todoroki et al (1999) reported that on the basis of simple cholecystectomy, complicated with surgical procedures including hepatic lobe resection, semi-hepatectomy, pancreaticoduodenectomies, partial gastrectomy or colectomy, the 5-year postoperative overall survival rate was around 25%-33% . Similarly, Sasaki et al (2006) reported that the 5-year overall survival rate of gallbladder cancer patients of Nvein IV stage who underwent expanded radical surgery was around 42.9% .…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Xu¹,

Liu²,

Liu³

2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Xu¹,

Liu²,

Liu³

2012

Asian Pacific Journal of Cancer Prevention

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“…In fact 5-year survival rates of 15–63% and 7–25% have been reported for T3 and T4 tumours, respectively (table 8) [3,10,11,12,13,14,15,16,17]. …”

Section: Discussionmentioning

confidence: 99%

Does the Presence of Jaundice and/or a Lump in a Patient with Gall Bladder Cancer Mean that the Lesion Is Not Resectable?

Varma

Gupta²,

Soin³

et al. 2009

Dig Surg

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Background: The presence of jaundice or an abdominal lump in gall bladder cancer (GBC) is often translated to advanced and unresectable disease. We examined whether this was true. Methods: We retrospectively analysed 120 GBC patients, who had been operated on, for presenting symptoms, staging and resectability. The outcomes in patients with jaundice and/or an abdominal lump were compared with those who did not have these features. Early disease was represented by stages I and II, while stages III and IV represented advanced disease. Results: Sixty-eight patients (57%) presented with an abdominal lump and 62 (52%) had jaundice. An abdominal lump, jaundice or both were present in 89 patients (74%), of whom 78 (88%) had advanced disease, while 22 of the 31 patients (71%) with neither jaundice nor an abdominal lump had advanced disease. Forty-four patients (50%) with either or both of these features had R0 resections, while 20 patients (64%) with neither jaundice nor an abdominal lump had R0 resections. The presence of jaundice or an abdominal lump was significantly associated with advanced disease (p = 0.025), but not with unresectability (p = 1). Conclusions: Jaundice or an abdominal lump was present in 74% of the patients with GBC. While this represented advanced-stage cancer, it did not preclude resectability.

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“…In the present study, 3-year DFS and OS rates in the patients that had undergone surgery alone without adjuvant therapy were 33% and 25.3%, respectively. Todoroki et al defended the viewpoint that radical cholecystectomy can be performed even in stage-IV disease [28] . Poor prognosis after surgery alone has brought forward chemotherapy and/or radiotherapy as adjuvant settings.…”

Section: Resultsmentioning

confidence: 99%

Adjuvant Therapy in Patients with Gallbladder Carcinoma

Cihan

Demi̇rci

Odabaş

et al. 2015

Journal of Gastroenterology and Hepatology Research

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AIM:This study aimed to investigate the effects of adjuvant therapy and chemotherapeutic agents on survival of patients with gallbladder carcinoma. Factors that may affect survival were examined. METHOD: The files of 74 patients who had been followed between 2004 and 2013 were retrospectively reviewed. Only stage I-III gallbladder carcinoma patients were included in the study. RESULTS: The median age was 65 (36-82) years and 55 (74.4%) of the patients were female. Stage I was determined in 12 (16.2%) patients, whereas Stage II and III were determined in 62 (83.8%) patients. All of the patients had undergone surgical intervention. Positive surgical margin was present in 21 (28.4%) patients and 14 (58.4%) of these patients were re-operated. Thirty-nine (52.7%) patients received chemotherapy. The combination of cisplatin-fluorouracil was the most commonly used chemotherapy regimen, received by 15 (38.5%) patients. Radiotherapy alone was performed in none of the patients, while 8 (10.8%) patients received chemoradiotherapy. Whereas DFS was 21±1.7 (17.2-24.9 95% CI) in the adjuvant therapy arm, OS was found to be 24±2.05 (19.9-28.9 95% CI). DFS was 23±6.7 (9.7-36.3 95% CI) and OS was 28±2.8 (22.5-33.5 95% CI) in the patients that did not receive adjuvant therapy. The differences in both DFS (p=0.246) and OS were not statistically significant (p=0.534). The effectiveness of adjuvant therapy on DFS and OS in the subgroups (surgical margin positivity, stage II patients, older than 65 years old) was statistically significant. CONCLUSION: There is no standard adjuvant therapy for gallbladder carcinoma. The present study demonstrated the favorable effect of adjuvant therapy, particularly for selected patients. Prospective studies in large patient groups are needed to clarify the benefits of adjuvant therapy.

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Treatment of gallbladder cancer by radical resection

Abstract: With careful patient selection, radical resection for gallbladder cancer improves the prognosis with acceptable operative mortality and morbidity rates, even for stage IV disease, provided that complete gross tumour resection is combined with radiotherapy.

Cited by 126 publications

References 8 publications

Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Does the Presence of Jaundice and/or a Lump in a Patient with Gall Bladder Cancer Mean that the Lesion Is Not Resectable?

Adjuvant Therapy in Patients with Gallbladder Carcinoma

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