“…OnaBTX-A is known to have a rapid onset of activity with peak benefits usually occurring approximately one-week posttreatment (Carruthers and Carruthers, 1998;Lowe et al, 2005). For this reason, many practitioners advocate pretreatment with neuromodulators before other aesthetic procedures to attain maximal synergy (Carruthers and Carruthers, 1998;Carruthers and Carruthers, 2003;Carruthers and Carruthers, 2004;Dubina et al, 2013;Kadunc et al, 2007;Khoury et al, 2008;Landau, 2006;Tung et al, 2011). In a randomized, blinded, split-face study, Khoury et al (2008) found that a significantly higher proportion of patients showed improvement in small wrinkles and fine lines with intense pulse laser plus BTX-A versus intense pulse laser alone (Khoury et al, 2008).…”