2013
DOI: 10.1111/jocd.12059
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Treatment of forehead/glabellar rhytide complex with combination botulinum toxin a and hyaluronic acid versus botulinum toxin a injection alone: a split‐face, rater‐blinded, randomized control trial

Abstract: Glabella and forehead lines can be effectively and safely reduced with neurotoxin alone as well as neurotoxin in combination with fillers. Combination treatment may provide a slightly better cumulative benefit and also increase the persistence of effect.

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Cited by 41 publications
(30 citation statements)
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“…29,35,36 Conclusions Dermal fillers have been used with onabotulinumtoxinA and bimatoprost for a combination approach to facial aesthetic treatment. 4,5 Although published reports describe clinical trial findings for the combined use of HA fillers and onabotulinumtoxinA for the treatment of specific facial areas, 12,37,38 this clinical trial utilized a unique combined treatment method with multiple modalities for a comprehensive, global, on-label approach. The perspectives and experience of the investigators with the injection pattern, sequencing, volume, and techniques in using VYC-20L, HYC-24L, HYC-24L+, and onabotulinumtoxinA provide a valuable guide to the use of these treatments in clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…29,35,36 Conclusions Dermal fillers have been used with onabotulinumtoxinA and bimatoprost for a combination approach to facial aesthetic treatment. 4,5 Although published reports describe clinical trial findings for the combined use of HA fillers and onabotulinumtoxinA for the treatment of specific facial areas, 12,37,38 this clinical trial utilized a unique combined treatment method with multiple modalities for a comprehensive, global, on-label approach. The perspectives and experience of the investigators with the injection pattern, sequencing, volume, and techniques in using VYC-20L, HYC-24L, HYC-24L+, and onabotulinumtoxinA provide a valuable guide to the use of these treatments in clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…The use of a combined approach in the treatment of photoaged skin has become more popular over the years. In the literature, studies and case reports have highlighted the success of multimodal regiments (involving adjunctive neuromodulator with fillers, intense pulse light, and laser resurfacing) within the aesthetic realm for improvement of rhytides and photodamage (Carruthers and Carruthers, 2003;Carruthers and Carruthers, 2004;Dubina et al, 2013;Goldman and Wollina, 2010;Kadunc et al, 2007;Khoury et al, 2008;Tierney and Hanke, 2010). Botulinum toxin has also proven helpful within the surgical sphere to minimize postoperative scar formation (Flynn, 2009;Gassner et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…OnaBTX-A is known to have a rapid onset of activity with peak benefits usually occurring approximately one-week posttreatment (Carruthers and Carruthers, 1998;Lowe et al, 2005). For this reason, many practitioners advocate pretreatment with neuromodulators before other aesthetic procedures to attain maximal synergy (Carruthers and Carruthers, 1998;Carruthers and Carruthers, 2003;Carruthers and Carruthers, 2004;Dubina et al, 2013;Kadunc et al, 2007;Khoury et al, 2008;Landau, 2006;Tung et al, 2011). In a randomized, blinded, split-face study, Khoury et al (2008) found that a significantly higher proportion of patients showed improvement in small wrinkles and fine lines with intense pulse laser plus BTX-A versus intense pulse laser alone (Khoury et al, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…There is still a lack of information on combination treatments with BoNT-A and fillers, and how the results of full-facial treatments are appreciated by the patients. 16,17 This study evaluated the subject satisfaction, efficacy, and safety of BoNT-A (s.U) and the RES filler range in combination for fullfacial aesthetic rejuvenation.…”
mentioning
confidence: 99%