Treatment of focal epithelial hyperplasia with trichloroacetic acid

Multifocal Epithelial Hyperplasia of Oral Cavity Expressing HPV 16 Gene: A Rare Entity

“…The prominent microscopic features consist of parakeratin layering, extensive acanthosis, epithelial cells of the spinous layer with enlarged nucleus, degeneration of koilocytes, and mitosoid cells [6]. Our case demonstrated multiple papillary epithelial projections with fibrovascular connective tissue cores and presence of koilocytes in the spinous layer of the epithelium favouring the diagnosis.…”

“…Harris Ricardo et al treated 4 cases of focal epithelial hyperplasia using 80% of trichloroacetic acid and observed resolution of the lesions within 45 days [6]. The prognosis of the disease is good, as most of the lesions remit spontaneously, although periodical clinical followups are crucial [4].…”

A severe manifestation of extensive multifocal epithelial hyperplasia (Heck's disease) and the role of CO2 laser as a treatment modality: A case report

“…Heck's disease usually regresses spontaneously, but the therapeutic intervention becomes a necessity when the lesions interfere with functional and aesthetic aspects 5,6 . Several therapeutic methods have been used to manage such conditions including surgical excision, 7,8 laser surgery, 9,10 cryotherapy, 11,12 in addition to the conservative treatments such as topical imiquimod, 13 trichloroacetic acid, 14 topical interferon‐β 15 and topical and systemic interferon‐α 16,17 …”