Multifocal Epithelial Hyperplasia of Oral Cavity Expressing HPV 16 Gene: A Rare Entity

Prabhat, M. P. V.; Lakshmi, Chintamaneni Raja; Madhavi, N.; Bhavana, Sujana Mulk; Gummadapu, Sarat; Ramamohan, Kodali

doi:10.1155/2013/871306

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…In addition, Clausen et al [ 18 ] had reported FEH in Greenland Eskimos, both children and adults, ranging in age from 2 to 79 years. Likewise, scarce case reports of FEH in patients over 60 years have been reported in Germany [ 5 ], Sri Lanka [ 6 ] and India [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review

Castro

Cruz

et al. 2016

J Clin Med Res

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Focal epithelial hyperplasia (FEH), or Heck’s disease, is a rare disease of the oral mucosa associated with infection by some subtypes of human papilloma virus, especially subtypes 13 or 32. The disease is predominantly found in children and adolescents with indigenous heritage, but other ethnic groups can be affected worldwide. To the best of the authors’ knowledge, it has not been reported in Brazil’s elderly population. This article describes a case of FEH in a 57-year-old Brazilian patient presenting since childhood, with multiple lesions in the lips, buccal mucosa and tongue. The solitary tongue lesion underwent excisional biopsy and the histopathological analysis showed parakeratosis, acanthosis, rete pegs with a club-shaped appearance, koilocytosis and the presence of mitosoid cells. These microscopic findings in conjunction with clinical presentation were sufficient to establish the accurate diagnosis of FEH. Polymerase chain reaction (PCR) was performed, but no one human papillomavirus (HPV) subtype could be identified. Clinicians must be aware of this rare oral disease, which can even affect elderly patients, as we described here. Treatment may be indicated in selected cases due to esthetic and/or functional problems.

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Section: Discussionmentioning

confidence: 99%

Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review

Castro

Cruz

et al. 2016

J Clin Med Res

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“…9 High-risk HPV-types may be found in benign HPV-associated oral lesions and low-risk (LR)-HPV types may be identified in malignant HPV-associated lesions like oropharyngeal SCC (OPSCC). 15 Some view the presence of HPV in the mouth as being an oral HPV carrier, or as a passenger infection [16][17][18] ; and these individuals are probable transmitters of the virus 19 through oral sex practices and through open mouth kissing among others. 2 The prevalence of HPV in the mouth and oropharynx has been studied globally, but there is an apparent lack of substantial data from sub-Saharan Africa, and specifically, South Africa.…”

Section: Oral and Oropharyngeal Hpv Prevalence In South Africamentioning

confidence: 99%

Oral and Oropharyngeal HPV prevalence in South Africa A systematic review and meta-analysis

Wood¹,

Motloba²,

Makwakwa³

et al. 2022

S. Afr. dent. j.

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Prevalence data for HPV infection in the head and neck in Southern African populations is lacking. In addition to cervical cancer, this sexually transmitted oncogenic virus is responsible for a subset of head and neck cancer and is transmitted via oral sexual routes, and through other forms of intimate contact between anatomical sites lined by mucosa. This systematic review and meta-analyses aimed to synthesize data for the prevalence of head and neck HPV infection in South Africa. Original research papers from South Africa reporting on the prevalence of HPV in the head and neck was systematically reviewed using PubMed, Ovid Medline, Embase and the Cochrane Library. A meta-analysis on the prevalence data wasconducted for 16 papers that met the inclusion criteria.

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“…The most frequent benign and malignant papilloma lesions in the maxillofacial area, associated with HPVs are presented in the table below: Нead and neck squamous-cell carcinoma (HNSCC) 6,11,16,18,31,33,35 HPVs attack squamoss epithelial cells. Unlike many other viruses, which infect the oral epithelium and destroy the cells, HPVs permeate and induce proliferative changes in these cells with subsequent cell transformations and the development of benign and malignant tumors.…”

Section: S S U E 1 2 0 1 5 Lesions In the Maxillofacial Area Assmentioning

confidence: 99%

“…Papillomaviruses are detected in epithelial cells via electronic microscopes, and it is generally assumed that these virulent units should be considered a form of disseminated oral papillomatosis with skin manifestations (9,12,13,31).…”

Section: S S U E 1 2 0 1 5 Lesions In the Maxillofacial Area Assmentioning

confidence: 99%

Human Papillomaviruses, Herpes Viruses and Oral Neoplasms

Krasteva¹,

Dobreva²,

Galabov³

et al. 2015

MedInform

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Human papillomaviruses constitute the most widely spread sexually transmitted viral infection world-wide. In about 1% of the cases, a continuing HPV infection can lead to the appearance of precancerous conditions. In a subsequent carcinoma progression, different types of cancer can develop -cervical, rectal, penile, oral, throat, laryngeal, etc. More than 200 HPV types have been established, with at least 25 found in lesions in the oral cavity.The attention of specialists in the field has been focused on the association between HPVs and oral carcinogenesis. It is highly recommended that each patient with a suspected lesion in the oral cavity should be tested for HPV.

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Multifocal Epithelial Hyperplasia of Oral Cavity Expressing HPV 16 Gene: A Rare Entity

Cited by 8 publications

References 6 publications

Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review

Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review

Oral and Oropharyngeal HPV prevalence in South Africa A systematic review and meta-analysis

Human Papillomaviruses, Herpes Viruses and Oral Neoplasms

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