Treatment of fibrosarcoma in a horse

Riggottt, J. M.; Quarmby, W. B.

doi:10.1111/j.2042-3306.1980.tb03425.x

Cited by 15 publications

(12 citation statements)

References 6 publications

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“…In horses, the mostcommonlyreported site forfibrosarcoma is the head,including periocular (6), premaxilla, andn asomaxillary regions (2,5,17). Other single reportso ff ibrosarcoma in horses include sitesinthe epaxialmuscles, the subcutisof the flank andrib regions,the omentum, kidneyand mediastinum (7,8,10,15,16,24) andone tumour on the hip, secondary to partialt hickness burnso vert he gluteal region (18).…”

Section: Discussionmentioning

confidence: 99%

“…In smalla nimals, adjunct therapy mayi nclude radiation, chemotherapyand immunotherapy (11). There arereports of chemotherapeutics andr adiation therapy for some tumour types in the horse (16,(20)(21)(22)(23), however, the expenseand difficultieso fa dministration of theset herapies maketheminaccessiblefor most equine patients.Additionally, amputation is not areasonableo ption for equine patients.I nt he currentc ase, the successful outcome may indicatel ong-termr esolutiono fc linical signs is possiblewithout the benefitofwide dissection margins during surgical excision. This maysuggest thatthe biological behaviour of fibrosarcoma is different in horses thani no thers pecies.…”

Section: Discussionmentioning

confidence: 99%

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Fibrosarcoma over the tarsal groove of a 14-month-old Quarter horse

Story¹,

Gaughan²,

Andrews³

et al. 2005

Vet Comp Orthop Traumatol

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A 14-month-old male Quarter horse was presented for evaluation of a grade 3 out of 5 (grade 0 = sound; grade 5 = non-weight bearing) right rear lameness. A firm, 8 x 16 cm mass was palpable at the caudal medial aspect of the distal tibia and proximal tarsal region of the right hind limb. A percutaneous needle aspirate contained mesenchymal cells that were moderate to large in size with single, oblong nuclei. Differential diagnoses included fibrous hyperplasia, fibroma, or well-differentiated fibrosarcoma. Excisional biopsy for both definitive diagnosis and treatment was offered and selected by the owner. A fibrosarcoma was confirmed by histological examination of the mass. One and a half years after resection signs of lameness or evidence of regrowth of the mass were not evident.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fibrosarcoma over the tarsal groove of a 14-month-old Quarter horse

Story¹,

Gaughan²,

Andrews³

et al. 2005

Vet Comp Orthop Traumatol

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“…Fibrosarcomas are found most often in dogs and cats, although they do occur in all species, including man. The cutaneous form in equidae has been described (REINERTSON, 1974;RIGGOTT and QUARMBY, 1980;PULLEY and STANNARD, 1990;JONES et al, 1997) and is considered to be rare. COTCHIN (1977) reported that x 3 YO of all neoplasms in horses are fibrosarcomas.…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of an Equine Preputial Fibrosarcoma Using 5‐Fluorouracil/Evaluation of the Treatment Using Quantitative PCNA and KI67 (MIB 1) Immunostaining (Case Report)

Roels

Ducatelle

Vijver

et al. 1998

Journal of Veterinary Medicine Series A

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Summary An 18‐month‐old cross‐bred Fjord pony colt presenting a fibrosarcoma of the prepuce with severe infiltrative growth, was treated by topical application of 5‐fluorouracil. Biopsies were taken before and after a treatment period of 2 months. As a control, preputial tissue from a healthy horse was biopsied. Tissue sections were stained immunohistochemically for Proliferating Cell Nuclear Antigen (PCNA) and Proliferation related factor — Ki67 (MIB1). Using computerized quantitative image analysis of these sections, Mitotic index (PCNA), Growth Fraction (Ki67) and total nuclear area percentage of the dermis were calculated. The Mitotic index, growth fraction and total nuclear area percentage were significantly (P < 0.001) reduced at the end of the treatment period compared to the initial biopsy tissue, but they still were significantly higher than the control values, due to a remnant inflammatory reaction to the cytostatic drug. After treatment of the lesion, the pony fully recovered with no visible residual lesions on the prepuce. On follow‐up 6 months after treatment, the horse showed no signs of recurrence. The success of the present treatment should encourage further clinical trials in cases of malignant fibrous tumours of skin in horses. The quantitative analysis of cell proliferation in biopsies can be used to evaluate treatment follow‐up.

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“…Fibrosarcomas are not common tumours in horses, 23 comprising 2% of cutaneous and musculocutaneous neoplasms 24 . They have been described in the premaxilla, 25 rostral mandible, 26 paranasal sinuses, 27,28 tarsal groove, 23 humerus, 29 epaxial musculature, 30 omentum, 31 mesentery, 32 abdominal cavity and wall, 33 kidney, 34 thoracic vertebrae and wall, 35 mammary gland 36 and prepuce 37 . A fibrosarcoma has also been reported following a burn injury in a horse 38 .…”

Section: Discussionmentioning

confidence: 99%

Myofibroblastic fibrosarcoma with multifocal osseous metaplasia at the site of equine influenza vaccination

Kannegieter¹,

Schaaf

Lovell

et al. 2010

Aust Veterinary J

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We describe a fibrosarcoma in a 12-year-old Quarterhorse ¥ Arabian gelding as a sequela to equine influenza vaccination. Shortly after the second vaccination, swelling at the site was noticed by the owner and it continued to increase in size over the following 6 months. Biopsy of the mass indicated a fibrosarcoma had developed at the vaccination site. It was approximately 20 cm in diameter and elevated well above the level of the skin. There was no clinical evidence of metastases to the lungs or local lymph nodes. Surgical resection of the mass was performed and the wound healed by first and second intention. Histopathological examination and immunohistochemical staining confirmed a myofibroblastic fibrosarcoma with multifocal osseous metaplasia. To the authors' knowledge, this is the first equine case of a vaccineassociated fibrosarcoma.

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Treatment of fibrosarcoma in a horse

Cited by 15 publications

References 6 publications

Fibrosarcoma over the tarsal groove of a 14-month-old Quarter horse

Fibrosarcoma over the tarsal groove of a 14-month-old Quarter horse

Successful Treatment of an Equine Preputial Fibrosarcoma Using 5‐Fluorouracil/Evaluation of the Treatment Using Quantitative PCNA and KI67 (MIB 1) Immunostaining (Case Report)

Myofibroblastic fibrosarcoma with multifocal osseous metaplasia at the site of equine influenza vaccination

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