Treatment of erosive vulvovaginal lichen planus with methotrexate

Jang, Nelly; Fischer, Gayle

doi:10.1111/j.1440-0960.2008.00472.x

Cited by 50 publications

(39 citation statements)

References 19 publications

(26 reference statements)

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“…MTX (7.5–20 mg once weekly, in combination with folic acid) showed most encouraging results in case series of both oral and anogenital LP in a total of 8 patients . In our experience low‐dose regimens (10 mg weekly combined with folic acid 5 mg weekly one day after MTX application) are well tolerated and often produce a rapid complete response as early as after one month of therapy (Figure ).…”

Section: Disseminated Skin Lesions and Exanthematous Lichen Planusmentioning

confidence: 68%

Individualizing treatment and choice of medication in lichen planus: a step by step approach

Manousaridis

Peitsch

et al. 2013

J Deutsche Derma Gesell

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SummaryAlthough lichen planus is one of the most common dermatological entities, very few reviews on its management exist in the literature. Standard therapeutic approaches include various topical treatments (including topical corticosteroids, calcineurin inhibitors, vitamin D analogs) and phototherapy modalities, as well as systemic corticosteroids and systemic retinoids. While localized skin lesions are easily managed with standard modalities, generalized forms and in particular involvement of hair follicles, nails and mucosa, as well as eyes are often challenging. This review proposes an evidence-based and differential therapeutic regime, taking into account many new emerging systemic therapies to help clinicians optimize treatment according to the type, extent and severity of the disease. An individual therapeutic ladder has been developed for each location, starting with standard modalities and ranking alternative systemic treatments (mainly methotrexate and hydroxychloroquine, as well as cyclosporine, azathioprine and mycophenolate mofetil) according to efficacy, evidence level and side-effect profile.

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Section: Disseminated Skin Lesions and Exanthematous Lichen Planusmentioning

confidence: 68%

Individualizing treatment and choice of medication in lichen planus: a step by step approach

Manousaridis

Peitsch

et al. 2013

J Deutsche Derma Gesell

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“…Tedaviye dirençli olgularda topikal kalsinörin inhibitörleri, sistemik azatiyopürin, siklosporin kullanılabilir. Sekonder enfeksiyon varsa kortikosteroidlerle antibiyotik veya antifungal kombinasyonu kullanılabilir (29)(30)(31)(32)(33)(34)(35)(36). İntroital daralma veya labial yapışıklık varsa cerrahi düzeltme, nadiren üriner retansiyon nedeniyle de acil cerrahi müdahale gerekebilir (35).…”

Section: Likenoid Paternunclassified

Vulvar Dermatoses

Dilek¹,

Saral²

2017

tdd

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“…[44] Some authors have used MTX in combination with topical agents like topical steroids, calcineurin inhibitors for the treatment of refractory type of erosive oral or genital lichen planus with good results. [45,46] Localized Scleroderma (Morphea) Methotrexate is emerging as the most frequently used systemic agent in the treatment of localized scleroderma in children. Low dose MTX can be used in combination with systemic corticosteroids for the treatment of rapidly progressive, disabling types of localized scleroderma in children.…”

Section: Lichen Planusmentioning

confidence: 99%