Treatment of Enterobiasis With One Oral Dose of Promethazine Hydrochloride

Bumbalo, Thomas S.

doi:10.1001/jama.1957.02980150019006

Cited by 4 publications

References 5 publications

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A Clinical Evaluation of Four Oxyuricides

Bumbalo¹

1960

Arch Pediatr Adolesc Med

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In recent years, attention has been focused on the increased incidence of parasitic diseases in the United States.1,2 Enterobiasis (infection by the pinworm Enterobius vermicularis) is still a common and troublesome pediatric problem, even though many investigators have reported a variety of successful treatments of this parasitic infection.3-6Simplification of treatment regimens can contribute immeasurably to a decrease in the incidence and a better control of this infection. To date, in a variety of regimens, we have evaluated the following drugs in the treatment of pinworm infection in children:Egressin (thymol-n-isoamylcarbamate), Diphenan (parabenzlphenylcarbamate), methylrosaniline chloride (gentian violet), oxytetracycline, papain, Cremothalidine, (a phthalylsulfathiazole preparation), carbomycin, garlic, piperazine, promethazine hydrochloride, pyrathiazine, and pyrvinium chloride.5,7-10 In a more recent study (5) we reported the results of treatment of 139 children infected with pinworms. Thirty-four children, varying in age and weight, were treated with a single dose of 3 gm. of piperazine citrate (Antepar) once daily for three consecutive days with a cure rate of 90.6%. Thirty-four children were treated with the same dose of piperazine citrate for two days with a fourday rest period between the two treatment days, with a cure rate of 86.2%. A third group of 35 children were treated with a daily dose of 1.5 mg. of pyrvinium chloride (Vanquin) per kilogram of body weight divided into two equal doses for six consecu¬ tive days with a cure rate of 100%. A fourth group of 36 children were treated with a

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