Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up

Pettine, Kenneth A.; Suzuki, Richard K.; Sand, Theodore T.; Murphy, Matthew B.

doi:10.1007/s00264-015-2886-4

Cited by 96 publications

(114 citation statements)

References 30 publications

Supporting

Mentioning

113

Contrasting

Order By: Relevance

“…Several studies have demonstrated improvement in clinical scores including ODI, VAS, and JOA beginning 1 month post-PRP injection [64][65][66][67]. Additionally, these studies have reported no complications associated with MSC and PRP injections [64].…”

Section: Treatment Non-operativementioning

confidence: 96%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

225

202

View full text Add to dashboard Cite

Purpose of Review Substantial advancements have been made in the cause, diagnosis, imaging, and treatment options available for patients with lumbar disc herniation (LDH). We examined the current evidence and highlight the concepts on the frontline of discovery in LDH. Recent Findings There are a myriad of novel etiologies of LDH detailed in recent literature including inflammatory factors and infectious microbes. In the clinical setting, recent data focuses on improvements in computer tomography as a diagnostic tool and non-traditional injection options including tumor necrosis alpha inhibitors and platelet-rich plasma. Operative treatment outcomes have focused on minimally invasive endoscopic approaches and demonstrated robust 5-year post-operative outcomes. Summary Advances in the molecular etiology of LDH will continue to drive novel treatment options. The role of endoscopic treatment for LDH will continue to evolve. Further research into10-year outcomes will be necessary as this surgical approach continues to gain widespread popularity.

show abstract

Section: Treatment Non-operativementioning

confidence: 96%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

225

202

View full text Add to dashboard Cite

show abstract

“…The study by Pettine et al, though it only included 26 subjects, demonstrated promising results (71 % reduction in VAS and [64 % improvement in ODI at 2 years) of BMC injection into one or two level degenerative discs in chronic LBP patients who had failed conservative treatment [17]. This study demonstrated that BMC injection can potentially provide long term relief (approximately 80 % avoided surgery at 2 years).…”

Section: Discussionmentioning

confidence: 55%

“…A recent study by Pettine et al evaluated 26 patients with chronic LBP after intradiscal injection of autologous BMC and performed follow-up from 3 months to 2 years post-injection [17]. The results demonstrated significant improvements in both ODI and VAS at one and 2 years.…”

Section: Injection Proceduresmentioning

confidence: 88%

“…There were studies published on intradiscal injections of various substances, including corticosteroid [8][9][10], methylene blue [11], etancercept [12], hypertonic dextrose [13], oxygen ozone (OOT) [14,15], chemonucleolysis with chymopapain [16], bone marrow concentrate (BMC) [17], and glucosamine/chondroitin [18]. Of these studies, seven were randomized controlled trials.…”

Section: Injection Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of Available Treatments for Discogenic Low Back Pain

Lucas

Stewart

Mattie

et al. 2016

Curr Phys Med Rehabil Rep

View full text Add to dashboard Cite

Discogenic pain is a known cause of low back pain (LBP). There are several proposed minimally invasive treatments in the literature including: percutaneous laser disc decompression, multiple radiofrequency thermocoagulation/ablative techniques, and intradiscal injection of varying medications. The body of literature suffers significantly from patient heterogeneity due to a lack of stringent inclusion criteria. Additional concerns in the literature include random follow-up times, variability in reported results, and non-reproducibility of findings. Collectively, these flaws significantly limit the conclusions that can be made regarding treating those with suspected discogenic pain. Despite this, the article will review the published literature to date on the interventional procedures for patients with suspected discogenic LBP.

show abstract

“…Early clinical studies for intradiscal injection of autologous bone marrow aspirate for discogenic back pain have been positive. Clinical follow up at 2 years after autologous bone marrow concentrate injection showed that 40% had improvement on MRI, while none had worse appearing MRI67 . Autologous bone marrow concentrate has been shown to significantly decrease lumbar discogenic pain, and that pain relief was improved at higher cell injection concentrations68 .…”

mentioning

confidence: 94%