Treatment of Debilitating Cremasteric Synkinesia With Intracremasteric Botulinum-A Toxin Injections

Mori, Ryan; Vasavada, Sandip; Baker, D C; Sabanegh, Edmund

doi:10.1016/j.urology.2011.03.011

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…These doses were selected as representatives for the minimum effective doses used for urologic indications . The repetition of injections was dictated by the fact that onabotA needs multiple injections due to its finite duration till acquiring therapeutic effect . All injections were given three times in a 2‐week interval.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, physicians must discuss with the families the potential risk for distant spread of the toxin and weigh this against the benefits that can be achieved. Other applications of onabotA in the pediatric population are retractile testes, and cremasteric synkinesia . This can be explained by the fact that onabotA relaxes the cremaster muscle, allowing proper descending of the testes.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Onabotulinumtoxin A on testes of the growing rat

Breikaa

Mosli

Abdel-Naim

2016

J Biochem & Molecular Tox

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Onabotulinumtoxin A (onabotA) is gaining wide medical use in children. The present study was planned to investigate the influence of its injection on the maturing testicular structures in rats. Immature rats were injected in the bilateral cremaster muscles by onabotA with three doses of (10, 20, and 40 U/kg) three times in a 2-week interval. The effect of these injections on fertility indices was examined. Levels of antisperm antibodies and several apoptosis parameters were also investigated. DNA content in form of ploidy and histopathological alterations were assessed. OnabotA-injected groups showed decreased sperm count and semen quality, while sperm vitality, morphology, and testosterone levels were not significantly affected. Furthermore, DNA flow cytometric analysis confirmed delayed sperm maturation. Apoptosis markers were significantly increased by the injections. In conclusion, onabotA injection in growing rats adversely affected sperm count and maturation. OnabotA testicular effects are mediated, at least partly, by apoptosis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Onabotulinumtoxin A on testes of the growing rat

Breikaa

Mosli

Abdel-Naim

2016

J Biochem & Molecular Tox

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“…Similar to adults, children with refractory detrusor overactivity associated with spina bifida and those suffering from cerebral palsy are nowadays candidates for the treatment with intradetrusal onabotA injections (Chancellor & Smith, 2011). Among the applications of onabotA in the pediatric age group, a potential application that has been suggested is the use of onabotA for retractile testes and cremasteric synkinesia (Mori et al, 2011). This can be explained by the fact that onabotA relaxes the cremasteric muscle, allowing proper descending of the testes.…”

Section: Introductionmentioning

confidence: 99%

Influence of onabotulinumtoxin A on testes of the growing rat

Breikaa

Mosli

Abdel-Naim

2016

Preprint

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Onabotulinumtoxin A (onabotA) is gaining wide medical use in children. However, little is known about its potential testicular effects. The present study was planned to investigate the influence of its injection on the maturing testicular structures in rats. Immature rats were injected in the peritesticular area by onabotA with three doses of (10, 20 and 40 U/kg) three times in a two-week interval. The effect of these injections on fertility indices (sperm parameters, semen quality and testosterone levels) was examined. In addition, levels of antisperm antibodies and several apoptosis parameters were investigated. DNA content in form of ploidy was compared to control group via flow cytometric analysis. Histopathological examination was carried out to confirm the findings. OnabotA-injected groups showed decreased sperm count and semen quality, while sperm vitality, morphology and testosterone levels were not significantly affected. Furthermore, DNA flow cytometric analysis confirmed delayed sperm maturation. Apoptosis markers were significantly increased by the injections. In conclusion, onabotA use in growing rats adversely affected sperm count and maturation. However, it had no significant effects on sperm morphology or vitality. OnabotA testicular effects are mediated, at least partly, by apoptosis.

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“…These doses were selected 90 as representatives for the minimum effective doses used for urologic indications (Cakmak et al,91 2003; Schurch & Reitz, 2004). The repetition of injections was dictated by the fact that 92 ONABOTA needs multiple injections due to its finite duration till acquiring therapeutic effect 93 (Mori et al, 2011). OnabotA was reconstituted with 4 ml 0.9 % saline and used within 1 h. All 94 injections were given three times in a two-week interval.…”

Section: Chemicalsmentioning

confidence: 99%

“…Among the applications of 68 onabotA in the pediatric age group, a potential application that has been suggested is the use of 69 onabotA for retractile testes and cremasteric synkinesia (Mori et al, 2011). This can be 70 explained by the fact that onabotA relaxes the cremasteric muscle, allowing proper descending of 71 the testes.…”

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confidence: 99%

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Treatment of Debilitating Cremasteric Synkinesia With Intracremasteric Botulinum-A Toxin Injections

Cited by 8 publications

References 6 publications

Influence of Onabotulinumtoxin A on testes of the growing rat

Influence of Onabotulinumtoxin A on testes of the growing rat

Influence of onabotulinumtoxin A on testes of the growing rat

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