Treatment of cystic ovarian disease in dairy cows with gonadotrophin‐releasing hormone: A field study

Hooijer, G.A.; Frankena, K.; Valks, M. M. H.; Schüring, Max-Peter

doi:10.1080/01652176.1999.9694988

Cited by 16 publications

(11 citation statements)

References 15 publications

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“…There was no difference between groups in the interval between treatment and first insemination. The conception rates between the groups were also similar suggesting that GnRH treatment was an effective therapy irrespective of the time 26 of diagnosis and treatment (Hooijer et al 1999). The response to treatment was not compared with a control group; hence, it is difficult to determine the efficacy of the GnRH treatment.…”

Section: Treatmentmentioning

confidence: 99%

“…This lack of difference between the treated and the control group may suggest that GnRH may not be as effective as it was thought to be, and, further, this also confirms the process of spontaneous recovery of cystic conditions. Another study attempted to determine the influence of time of treatment of GnRH in the postpartum period on the recovery rate of cystic conditions (Hooijer et al 1999). In this field study, cystic cows were treated with a single dose of 500 lg GnRH intramuscularly either before or after day 60 following 25…”

Section: Treatmentmentioning

confidence: 99%

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An Update on Cystic Ovarian Degeneration in Cattle

Peter

2004

Reprod Domestic Animals

160

145

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Cystic ovarian degeneration (COD) is considered to be one of the most important causes of reproductive failure in cattle. There is a severe economic loss to dairy industry because COD increases days-open in the postpartum period and the culling rates. The disease process is a consequence of a mature follicle that fails to ovulate at the appointed time of ovulation in the oestrous cycle. This anovulatory follicular structure either regresses or persists as a follicular or luteal cyst depending upon its structural/functional characteristics. The cells lining the follicular cyst synthesize oestrogen that, in certain instances, forces the animal to exhibit clinical signs of nymphomania. Besides oestrogen production, as per recent findings, they are also capable of secreting varying amount of progesterone which may dictate their fate. The animals that carry a luteal cyst may tend to be in anoestrus as the higher amount of progesterone secreted by this luteinized structure may change the pattern of gonadotrophins' secretion. Present findings suggest that perturbation of the hypothalamo-hypophyseal-ovarian (HHO) axis, due to many exogenous and endogenous factors, as the cause for anovulation. For example, it has been suggested that lack of hypothalamic or hypophyseal response to the positive feedback effect of oestrogens that are secreted by the dominant follicle as one of the many causes. The non-physiological changes that occur in the receptor expression of the HHO axis for the hormones involved in maturation, deviation, dominance and ovulation of the follicle may be yet another cause. The changes that occur at the cellular and molecular level in the ovary (in response to the factors mentioned above) that contribute to anovulation remain to be documented. This approach would allow us to completely understand the disease process. Hitherto, hormonal preparations that release luteinizing hormone from the anterior pituitary or have luteinizing hormone-like action are used to treat follicular cysts. GnRH belongs to the former group and human chorionic gonadotrophin (hCG) hormone forms the latter group. Treatment with a luteolytic agent, prostaglandin F2alpha (PGF2alpha), is successful if a luteal cyst is diagnosed properly. Many agents may be developed in the future if the cellular and molecular pathways of the disease process are delineated. This article will review recent advances in our understanding of the pathogenesis of COD and suggest direction for future studies to completely understand the disease mechanism. This review will also discuss the existing method of treatments for cysts and methods proposed for treatment of cysts that tend to be refractory in nature.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

An Update on Cystic Ovarian Degeneration in Cattle

Peter

2004

Reprod Domestic Animals

160

145

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“…Among the major reproductive problems that have direct impact on reproductive performance of dairy cows are abortion, dystocia, Retained Fetal Membrane (RFM), pyometra, metritis, prolapse (uterine and vaginal), anoestrus and repeat breeder. They are classified as before gestation (anoestrous and repeat breeding), during gestation (abortion, vagina prolapsed and dystocia) and after gestation (retained fetal membrane and uterine prolapsed) [2,13,29,18].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Major Reproductive Disorders of Dairy Cattle in Urban and Per Urban Area of Hosanna, Southern Ethiopia

Haile¹,

Tsegaye²,

Tesfaye³

2014

AVS

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Abstract:The study which employed both questionnaire and observational survey was conducted in urban and per urban area of Hossana with the objectives of determining the prevalence of major reproductive health problems of dairy cattle and the possible risk factors in the selected dairy farms from November 2013 to April 2014. A total of 390 dairy cattle (349 cross and 41 local breed) which were kept under different management system (256 intensively, 60 semi intensively and 74 were extensive) were included, out of which 43.07 % (n=168) were found to be affected either with one or more of reproductive problems. Repeat breeder, anoestrus, Retained Fetal membrane (RFM), and dystocia were found to be the major reproductive health problems containing 13.08%, 12.06%, 7.18% and 5.9% prevalence rate respectively and other reproductive health problems observed with lower prevalence include vaginal prolapsed, abortion, mixed and uterine prolapsed having 3.44%, 2.56%, 1.03%, and 0.76% respectively in the study farms of the area. The overall prevalence of reproductive problems showed significant difference (p<0.05) with respect to body condition and parity of dairy cattle where major reproductive health problems were observed more frequently in poor body conditioned and pluriparus cows. Whereas breed and management system were not found to have a significant influence (p>0.05) on the occurrence of reproductive problems in the area. Therefore, it is recommended that awareness creation to farm owners, attendants and improved management such as, proper feeding, accurate heat detection, considering the size of sire and dam while using AI, and health management should be improved to minimize the occurrence of these problems and associated economic losses in the dairy farms of the area.

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“…The COD-positive cows were treated with 500 lg gonadorelin [Fertagyl Ò ; Janssen-Cilag (originally Akzo-Intervet), Tilburg, the Netherlands] at the day of diagnosis. If animals were not pregnant after at least three inseminations (repeat breeder), they were examined again (Hooijer et al, 1999(Hooijer et al, , 2001(Hooijer et al, , 2003. No blood parameters were determined when cows were treated.…”

Section: Measurementsmentioning

confidence: 99%

“…Human chorionic gonadotrophin (hCG) has LH activity, inducing follicular growth. Gonadotrophin-releasing hormone (GnRH) induces also LH release, and oestrus usually occurs within 4 weeks after treatment (Dinsmore et al, 1990;Hooijer et al, 1999). The GnRH and hCG elicit equivalent endocrine and clinical responses, but for routine treatment GnRH has an advantage over hCG because of its minimal antigenicity (Drost and Thatcher, 1992).…”

Section: Introductionmentioning

confidence: 99%

Influence of Negative Energy Balance on the Reproductive Performance after Treatment of Cystic Ovarian Disease with Gonadotrophin‐releasing Hormone in Dairy Cows*

Hooijer¹,

Oijen²,

Frankena³

et al. 2005

Journal of Veterinary Medicine Series A

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The aim of this study was to investigate whether a significant relation exists between the presence of a negative energy balance (NEB) in cows early in lactation and the reproductive performance after treatment with gonadotrophin-releasing hormone of cows with clinical cystic ovarian disease. Reproductive performance after treatment was assessed from the interval between treatment and first insemination (ITFI) and the interval between treatment and conception (ITC). Based on the outcome of the daily change of milk fat yield (Deltafatg) between the first and second milk recordings post-partum, cows were considered to have passed the NEB nadir (positive Deltafatg) or not (negative Deltafatg). Lactations (n = 430) were divided into four groups according to the interval between calving and first milk recording (ICMR): (i) 0-9 days; (ii) 10-19 days; (iii) 20-29 days; (iv) 30-49 days. The relation between a NEB-proxy parameter (Deltafatg) and reproductive performance was determined. A significant interaction existed for groups 1 and 3 (ICMR on 0-9 and 20-29 days post-partum respectively) with an increased and a decreased probability of being inseminated the first day after treatment (ITFI) respectively. However, no significant interaction was found between Deltafatg and the groups with regard to ITC.

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Treatment of cystic ovarian disease in dairy cows with gonadotrophin‐releasing hormone: A field study

Cited by 16 publications

References 15 publications

An Update on Cystic Ovarian Degeneration in Cattle

An Update on Cystic Ovarian Degeneration in Cattle

Assessment of Major Reproductive Disorders of Dairy Cattle in Urban and Per Urban Area of Hosanna, Southern Ethiopia

Influence of Negative Energy Balance on the Reproductive Performance after Treatment of Cystic Ovarian Disease with Gonadotrophin‐releasing Hormone in Dairy Cows*

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