Treatment of Cutaneous Warts With Multiple Puncture Technique

McLaughlin, Joseph S.; Fischer, Thomas J.; Merrell, Gregory A.

doi:10.1177/1558944718771389

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…In 1969, Falknor et al 12 was the first one who started a new technique using only needles for pricking the warts as a modality of treatment. Also, Mclaughlin et al 13 used an 18‐gauge needle to puncture warts for the treatment of 16 patients. They reported that complete response was seen in 85% of the patients.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of microneedling alone vs its combination with 5‐fluorouracil solution vs5‐fluorouracilintralesional injection in the treatment of plantar warts

Ghonemy

Ali

Ebrahim

2020

Dermatologic Therapy

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Intralesional 5-fluorouracil (IL5-FU) has been used off-label for warts treatment; however, its use was limited by intense pain. Combination treatment can offer a robust therapeutic effect. Was to assess the therapeutic efficacy, safety and tolerability of microneedling vs its combination with 5-FU solution vs IL5-FU in the treatment of plantar warts. Ninety patients with plantar warts were divided randomly into three groups each containing 30 patients. Group A received (intralesional 5-FU), group B (microneedling) while group C (microneedling and 5-FU solution). All groups received treatment for a maximum of six sessions 2 weeks apart. Complete response was observed in 86.7% of the warts treated with 5-FU and microneedling (group C) vs to 76.7% and 70% in group A and B, respectively, with no statistically significant difference (P = .36). A significant increase in the number of sessions (P = .01) and pain score (P = .001) were found among group A compared to groups B and C. Patient's satisfaction was higher in group C (P = .05). No recurrence was reported in all groups. Microneedling can be used as alternative or adjuvant therapeutic modality for plantar warts treatment and significantly associated with less pain. Combination group was superior compared to the others.

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Section: Discussionmentioning

confidence: 99%

The efficacy of microneedling alone vs its combination with 5‐fluorouracil solution vs5‐fluorouracilintralesional injection in the treatment of plantar warts

Ghonemy

Ali

Ebrahim

2020

Dermatologic Therapy

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“…Intralesional needling creates a pathway for immune cells to access the lesion, and increases blood flow to the lesion, all of which may lead to an immune‐mediated destruction of the wart 30 . Like other forms of medicine therapy, intralesional drug therapy has significant downsides that have sparked discussion such as immediate side effects, including pain during administration, bleeding, high risk of infection, and allergic reaction in addition to skin changes such as atrophy, telangiectasia, and pigmentary changes 31…”

Section: Discussionmentioning

confidence: 99%

“…Intralesional needling creates a pathway for immune cells to access the lesion, and increases blood flow to the lesion, all of which may lead to an immune-mediated destruction of the wart. 30 Like other forms of medicine therapy, intralesional drug therapy has significant downsides that have sparked discussion such as immediate side effects, including pain during administration, bleeding, high risk of infection, and allergic reaction in addition to skin changes such as atrophy, telangiectasia, and pigmentary changes. 31 The promising results of this study, encourage the use of combined intralesional furosemide and digoxin as a successful therapy in cases of multiple cutaneous warts with low/absent recurrence potential, insignificant adverse effects and the absence of scarring that may occur with other conventional destructive modalities.…”

Section: Discussionmentioning

confidence: 99%

Intralesional combined furosemide and digoxin in cutaneous warts treatment: A randomized controlled clinical trial

lofty

Elbakry

Omar

et al. 2022

Dermatologic Therapy

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Although being a benign lesion, Warts can affect the quality of life by causing discomfort, disfigurement, and social embarrassment besides the tendency to spread.Cutaneous wart treatment faces many challenges as the development of an antiviral drug that can eradicate the human papilloma virus (HPV) is difficult. This clinical study aimed to assess the efficacy and safety of intralesional combined furosemide and digoxin in the treatment of multiple cutaneous warts. This double blinded randomized clinical trial included 80 adult patients with multiple cutaneous warts (≥2 warts) who were randomized into two groups, Group I (40 patients) treated with intralesional combined furosemide and digoxin and Group II (40 patients) who were treated with intralesional normal saline solution as a control group, weekly till improvement or for maximum five sessions. Clinical and dermoscopic evaluation at baseline, every session, and monthly for 6 months after the last session to detect any recurrence was performed. Complete wart clearance was observed in 92.5% of patients in the intralesional combined furosemide and digoxin group (Group I) compared with 10.0% in saline group (Group II), with highly statistically significant difference (Pvalue = 0.000). Pain during injection in 95.0% and 45.0% of patients in Group I and Group II respectively, treatment group was superior compared to control group.Intralesional injection of combined furosemide and digoxin can be a safe and effective treatment option in multiple cutaneous warts with minimal side effects in this study.

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“…These micro injuries set up a wound healing cascade, in which platelets release chemotactic and growth factors causing invasion of other platelets, neutrophils, monocytes/macrophages, and new collagen production (De Vita and Goldust, 2018). It also creates a pathway for immune cells to access the lesion, and increases blood flow to the lesion, all of which may lead to an immune-mediated destruction of the wart (Mclaughlin et al, 2019).…”

Section: -Fluorouracil (5-fu) Is An Antimetabolite That Suppresses Ce...mentioning

confidence: 99%

Topical 5 Fluorouracil and Microneedling in the Treatment of Planter Warts: Randomized Comparative Trial

2022

Al-Azhar Medical Journal

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Background: Warts are benign proliferations of skin and mucosa that result from infection with human papilloma virus (HPV) which are double stranded deoxyribonucleic acid (DNA) viruses that replicate inside the nucleus. Infection with HPV may be clinical, subclinical, or latent.Objective: To compare the efficacy and safety of intralesional 5-FU solution and 5-FU solution using micro needling technique in the treatment of planter warts. Patients and methods:Our study was carried out on 60 patients complaining of planter warts divided into two equal groups: A and B from June 2020 to Janurary 2021, Group A: with planter warts received intralesional 5-FU solution every two weeks, and Group B:with planter warts received 5-FU solution using a micro needling pen type device every two weeks, for maximum period of six sessions or complete absence of the lesion. Patients were selected from out-

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Treatment of Cutaneous Warts With Multiple Puncture Technique

Abstract: Barbotage, the multiple puncture of cutaneous warts, may be a reasonable treatment with minimal morbidity.

Cited by 4 publications

References 3 publications

The efficacy of microneedling alone vs its combination with 5‐fluorouracil solution vs5‐fluorouracilintralesional injection in the treatment of plantar warts

The efficacy of microneedling alone vs its combination with 5‐fluorouracil solution vs5‐fluorouracilintralesional injection in the treatment of plantar warts

Intralesional combined furosemide and digoxin in cutaneous warts treatment: A randomized controlled clinical trial

Topical 5 Fluorouracil and Microneedling in the Treatment of Planter Warts: Randomized Comparative Trial

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