Treatment of cutaneous pseudolymphoma with interferon alfa-2b

A case of cutaneous pseudolymphoma with a distinctive appearance treated successfully by intralesional interferon alpha‐1b and corticosteroids

“…As noted previously, the primary lesion nearly subsided after administering only nine doses of intralesional interferon combined with three doses of intralesional betamethasone. Although intralesional corticosteroid therapy is common, to the best of our knowledge, intralesional interferon therapy has been reported in only three cases of CPL 4‐6 . In our case, the good outcome may be attributable mainly to the anti‐proliferative and anti‐inflammatory effects of both interferon and corticosteroids, as well as the immunosuppressive effects of corticosteroids.…”

Subcutaneous Interferon Alfa for the Treatment of Cutaneous Pseudolymphoma

“…Two reports 7,8 in the literature have identified improvement with intralesional interferon therapy, but our case is the first, to our knowledge, to use systemic interferon. Intralesional interferon therapy may be a reasonable choice for a single persistent lesion, but a patient with multiple lesions in whom there is concern about new ones developing would best be served by systemic interferon therapy.…”

Treatment of Cutaneous Lymphoid Hyperplasia with Rituximab: A Case Report of 3 Patients

“…Persistent skin lesions show malignant potential. Different treatments of these lesions with different levels of success are Antibiotics (oral doxycycline), Biological agents (interferon-alfa-2b and TNF-antibodies), Corticosteroids (topical, intralesional, and systemic), External beam radiation, Immunosuppressants (azathioprine and cyclosporine) and Ultraviolet B phototherapy [5][6][7][8][9][10].…”