Treatment of condyloma acuminatum using the combination of laser ablation and ALA-PDT

hu, shaoshan; Yang, Yan; Jiang, Bingbing; Su, Dongqiang; Zhang, Likun; Huang, Zheng; Zhang, Feng

doi:10.1016/j.pdpdt.2018.12.006

Cited by 40 publications

(16 citation statements)

References 19 publications

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“…It is a common method for clinical treatment of CA. It can accurately and completely cut and destroy the wart [ 13 , 14 ]. However, studies have pointed out that human papillomavirus infections can occur within 1 cm of the wart body of CA.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Cao

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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’Purpose. To observe the clinical efficacy and safety of carbon dioxide laser combined with ALA photodynamics in the treatment of condyloma acuminatum. Method. A total of 211 patients with condyloma acuminatum admitted to our hospital from April 2018 to June 2021 were selected as the observation object. They were divided into the intervention group (CO2 laser combined with ALA photodynamic therapy, 125 cases) and conventional group (CO2 laser treatment, 86 cases), and the efficacy and incidence of adverse reactions between the two groups were compared. Result. The total effective rate of the intervention group (96.00%) was significantly higher than that of the conventional group (84.88%) ( P < 0.05 ). The total incidence of adverse reactions in the intervention group (8.00%) was lower than that in the conventional group (32.56%) ( P < 0.05 ). Univariate analysis showed that the patient’s smoking history, drinking history, course of disease, wart area, and number of sexual partners were related to the short-term prognosis ( P < 0.05 ). Multivariate logistic regression analysis showed that the patient’s course of disease, the area of the wart body, and the number of sexual partners were independent factors affecting the prognosis of patients with condyloma acuminatum ( P < 0.05 ). Conclusion. Carbon dioxide laser combined with ALA dynamics treatment of condyloma acuminatum significantly improves the clinical efficacy, does not increase the incidence of adverse reactions, and has important clinical therapeutic value. The course of the disease, the area of the wart, and the number of sexual partners are independent factors affecting the prognosis of patients with condyloma acuminatum.

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Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Cao

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Various treatments for CA, including surgical excision, cryotherapy, imiquimod cream, and photodynamic therapy, all involve the universal challenges of thoroughly clearing human papillomavirus (HPV) infections and radically curing CA lesions. 4,[6][7][8][9][10][11][12] However, infection by HPV is intrinsically interconnected with the body's immune functions. Specifically, T cellular immunity plays significant roles in the activation of HPV and the occurrence, cure, and relapse of CA.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum

Shen

Fan

et al. 2020

Journal of Medical Virology

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Background Condyloma acuminatum (CA) is both highly infectious and frequently recurring and requires long‐term, repeated treatments, which seriously affect the physical and psychological health of patients. The purpose of the present study was to investigate the effectiveness of a combination therapy of traditional Chinese medicine and CO2 laser on CA and the relationship between CA relapse and cellular immunity. Methods The study cohort consisted of 160 CA patients who underwent ambulatory treatment between January 2017 and January 2019 in the Department of Dermatology and Venerology of our hospital. The 160 patients were randomly divided into two groups: a combination therapy group (80 cases), who underwent CO2‐laser treatment followed by three courses of oral traditional Chinese medicine and a control group (80 cases), who were only treated with the CO2 laser to remove warts. The efficacy of the CO2‐laser treatment was evaluated on the first month after treatment and relapse was evaluated at monthly follow‐ups for 6 months. Additionally, 20 normal volunteers were also recruited. Three months before and after treatment, the cellular immunity factors of peripheral blood T lymphocyte subsets, including CD4+, CD8+, CD4+/CD8+, and interleukin‐2 (IL‐2), were detected and compared between CA patients and normal volunteers, the combination therapy and control groups, and the relapse and cure groups to determine whether there were statistical differences. Results Compared with normal volunteers, CA patients exhibited lower CD4+, CD4+/CD8+, and IL‐2 levels and higher CD8+ levels (P < .05). In addition, the rates of relapse for the combination therapy and control groups were 25.7% and 40.8%, respectively. However, the comprehensive immunity factors showed no statistical difference (P > .05) before treatment. Three months after treatment, factors including CD4+ and CD4+/CD8+ were higher in the combination therapy group than in the control group (P < .05), and CD8+ and IL‐2 showed no statistical difference (P > .05); factors including CD4+, CD4+/CD8+, and IL‐2 were higher and CD8+ was lower in the cure group than in the relapse group (P < .05). Conclusion The therapy combination of traditional Chinese medicine and CO2‐laser treatment can reduce the relapse rate of CA. It might be that traditional Chinese medicine combined with CO2‐laser treatment regulate liver meridian, Qi and blood, and restore the balance between various subgroups.

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“…Recently, the clinical effects of the combination of CO 2 laser ablation followed by 3 times ALA-PDT were investigated in a single-arm prospective study of 98 cases of both sexes. Three months after the treatment, 93.8% of patients showed complete cure of the treated area, but 18 patients showed new lesions in the surrounding skin [106]. These results were challenged by a following phase III prospective randomized double-blind study of 175 patients that reported that adjuvant ALA-PDT of condylomata acuminata after CO 2 laser ablation did not help in preventing recurrence of anogenital warts [107].…”

Section: Skin Infectionsmentioning

confidence: 99%

A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions

et al. 2020

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Background: In the past 30 years, topical photodynamic therapy (PDT) has been investigated for the treatment of a broad spectrum of cosmetic, inflammatory, and infectious skin conditions with variable, and often contrasting, results. However, the non-expert clinician may be in difficulty evaluating these results because different sensitizers, concentrations, formulations, light sources, and irradiation protocols have been used. In addition, many of these studies have poor quality design being case reports and uncontrolled studies of few cases. Summary: With the aim to clarify the potential usefulness of PDT for the treatment of infectious and inflammatory skin diseases as well as selected cosmetic indications, we searched for randomized controlled clinical trials, non-randomized comparative studies, retrospective studies, and case series studies with a number of at least 10 patients, published since 1990. Later, we reappraised the results in order to give a simple critical overview. Key Messages: Evidence from the literature seems to strongly support the use of ALA- and MAL-PDT for the treatment of common skin diseases such as acne, warts, condylomata, and Leishmania skin infection and for photorejuvenation, i.e., the correction of selected cosmetic changes of aging and photoaging. For other disorders, the level of evidence and strength of recommendation are lower, and controlled randomized studies with prolonged follow-ups are necessary in order to assess the clinical usefulness and other potential advantages over current treatment options.

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Treatment of condyloma acuminatum using the combination of laser ablation and ALA-PDT

Cited by 40 publications

References 19 publications

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum

A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions

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Treatment of condyloma acuminatum using the combination of laser ablation and ALA-PDT

Cited by 40 publications

References 19 publications

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Clinical Efficacy of Carbon Dioxide Laser Combined with ALA Photodynamics in the Treatment of Condyloma Acuminatum

Effectiveness of a combination therapy of traditional Chinese medicine and CO2 laser treatment for condyloma acuminatum

A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions

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Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum