Treatment of Comorbid Alcohol Dependence and Anxiety Disorder: Review of the Scientific Evidence and Recommendations for Treatment

Gimeno, Carmen Pastor; Dorado, Marisa Luisa; Roncero, Carlos; Szerman, Néstor; Vega, Pablo Barranco; Balanzá‐Martínez, Vicent; Álvarez, F. Javier

doi:10.3389/fpsyt.2017.00173

Cited by 51 publications

(32 citation statements)

References 91 publications

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“…In particular, alcohol consumption is strongly associated with suicides, and this may be due to low serotonin activity leading to aggressiveness and impulsivity . In addition, alcohol dependence often coexists with depression and anxiety disorders , with alcohol use often being a form of self‐medication to manage depression and anxiety , and this psychiatric comorbidity has a major impact on suicidal behaviour . Alternatively, having a religion may lead to empowerment, sense of meaning in life or positive affects, and these may buffer individuals from suicidal behaviour .…”

Section: Discussionmentioning

confidence: 99%

The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom

Jacob

Haro

Koyanagi

2018

Acta Psychiatr Scand

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The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom.Objective: The goal was to analyze the association of religiosity with suicidal ideation and suicide attempts in a UK nationally representative sample.Methods: This study used cross-sectional data from 7403 people who participated in the 2007 Adult Psychiatric Morbidity Survey (APMS). Religion was assessed with the question 'Do you have a specific religion?' with 'yes' and 'no' answer options. Lifetime and past 12month suicidal ideation and suicide attempts were assessed. The association between religiosity and suicidality was studied in multivariable logistic regression models adjusted for sociodemographic, behavioural, and psychopathological factors. Results: Compared to those without a religion, the prevalence of past 12-month suicidal ideation (3.2% vs. 5.4%), past 12-month suicide attempts (0.4% vs. 0.9%), lifetime suicidal ideation (11.2% vs. 16.4%), and lifetime suicide attempts (3.6% vs. 6.0%) was lower among those with a religion. In the fully adjusted model, having a religion was significantly associated with lower odds for all types of suicidality except past 12-month suicide attempts: suicidal ideation (past 12month: OR = 0.71, 95% CI = 0.51-0.99; lifetime: OR = 0.83, 95% CI = 0.69-0.99) and suicide attempts (past 12-month: OR = 0.71, 95% CI = 0.35-1.45; lifetime: OR = 0.69, 95% CI = 0.53-0.90). Conclusion: There is a negative association between religiosity and suicidality in the UK. Future studies should focus on the underlying mechanisms. Significant outcomes• The prevalence of suicidal ideation and suicide attempts was lower in religious people than in non-religious people in the UK.• There was a significant and negative relationship of religiosity with suicidal ideation (past 12-month and lifetime) and suicide attempts (lifetime) after adjustment for sociodemographic, behavioural, and psychopathological factors.• Future studies are needed to gain a better understanding of the underlying mechanisms involved in this association. Limitations• More detailed series of questions on religiosity would have allowed for a better estimation of the religiosity-suicidality relationship.• Suicidality was assessed with self-reports. As suicide is associated with stigma, participants might have responded in a socially desirable manner, potentially leading to an underestimation of the associations.• The design of this study was cross-sectional, and it was thus not possible to determine causality or temporality in the association between religiosity and suicidal ideation or suicide attempt.

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Section: Discussionmentioning

confidence: 99%

The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom

Jacob

Haro

Koyanagi

2018

Acta Psychiatr Scand

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“…High comorbidity rates exist between SUD and AD. [35][36][37] Studies had shown that high AD is related to increased use of substances, increased severity of alcohol withdrawal, and higher relapse rates following substance abuse treatment, 15,[38][39][40] as well as HADDAD ET AL.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with anxiety disorders among patients with substance use disorders in Lebanon: Results of a cross‐sectional study

Haddad¹,

Darwich

Obeïd

et al. 2019

Perspect Psychiatr Care

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Objectives: Estimate the rate of anxiety disorders (AD) and associated factors among patients with substance use disorder (SUD) in Lebanon. Methods: A cross-sectional study, conducted between April and September 2017, enrolled 57 inpatients with SUD. Results: The rate of AD in patients with SUD was 61.4%. The university level of education compared to the primary level of education (ORa = 0.221) was significantly associated with lower anxiety among patients with SUD. Being sexually abused and having a family history of depression tended to significance. Practical Implications: AD is widespread in Lebanon and high rates of anxiety in patients with SUD were found, warranting the implementation of strategic interventions and establishing national policies and legislation for mental health services to provide optimal care. K E Y W O R D S addiction, anxiety disorder, risk factors, substance use disorder 1 | INTRODUCTION Anxiety disorders (AD) are among the most commonly occurring mental disorders worldwide, estimated to have a lifetime prevalence up to 33% 1 and a global prevalence ranging from 4.8 to 10.9%. 2 In Lebanon, 11.2% of the people suffer from an anxiety disorder, which represents around 560 000 inhabitants out of a total of about 5 million. 3,4 Lebanon witnessed a series of wars, local armed combats, and terrorist attacks, 5 in addition to a series of crises including clean water penury, electrical power failure, and waste management problems that had overwhelmed the country. 5 Moreover, a high number of Syrian refugees had led to high levels of unemployment and competition for employment with locals. This is concurrent with the lack of public awareness about these Souheil Hallit and Fouad Tahan are last co-authors. This work has been done in the frame of the "Behavioral and Cognitive Neuroscience Master 2 Program," Faculty of Sciences, Lebanese University.

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“…In this line, studies have reported clinical cases where treatment with SSRIs appears to be the cause of increased frequency of intoxication by alcohol and new onset of alcohol-related problems [103][104][105]. Finally, patients who actively drink suffering of comorbid anxiety and AUD have also shown that they may increase alcohol consumption under treatment with SSRIs [106].…”

Section: Clinical Evidence Of Antidepressant Treatment Improves Deprementioning

confidence: 99%

Rethinking the Use of Antidepressants to Treat Alcohol Use Disorders and Depression Comorbidity: The Role of Neurogenesis

Ballesta¹,

Alén²,

Fonseca³

et al. 2019

Antidepressants - Preclinical, Clinical and Translational Aspects

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Patients with alcohol use disorders (AUDs) are frequently treated with antidepressant drugs (ADs), but clinical evidence of their efficacy is contradictory. Considering that ADs are thought to produce their therapeutic effects partially by increasing hippocampal plasticity and neurogenesis (HN), and that both AUDs and depression share a potential for the disruption of these neuroplastic processes, one could reasonably wonder whether the poor efficacy of AD treatment could be explained by the inability of these drugs to exert their proper action in patients suffering from AUD or depression. In order to further clarify this question, this chapter aims to examine available data regarding the effect of ADs on behavioral and HN alterations related to alcohol abstinence, as a key period in which the treatment would be implemented and in which their potential effects on alcohol-related problems remain under controversy.

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Treatment of Comorbid Alcohol Dependence and Anxiety Disorder: Review of the Scientific Evidence and Recommendations for Treatment

Cited by 51 publications

References 91 publications

The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom

The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom

Factors associated with anxiety disorders among patients with substance use disorders in Lebanon: Results of a cross‐sectional study

Rethinking the Use of Antidepressants to Treat Alcohol Use Disorders and Depression Comorbidity: The Role of Neurogenesis

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