Treatment of Chromomycosis With 5‐fluorocytosine

Kusunoki, Toshio; Tashiro, Hirotsugu; Tanaka, Michio; Ueda, Tokishi; Harada, Seiichi

doi:10.1111/j.1346-8138.1976.tb00982.x

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…Es md3 jedoch beriicksichtigt werden, daD alle Chromomykoseerreger eine hohe Resistenzfrequenz gegen 5-Flucytosin aufweisen (38). Sekundare Resistenzentwicklung unter 5-Flucytosin-Behandlung fihrte mehrfach zu Krankheitsriickfdlen (10,14,25,35,41).…”

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Klinik, Diagnostik mid Therapie der Chromomykose

Mittag¹,

Kreysel²

1982

Mycoses

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Zusammenfassung: Bei der Chromomykose handelt es sich um eine selten vorkommende, chronische, fast ausschlieBlich die Haut betreffende Infektion, hervorgerufen durch bestimmte dunkelpigmentierte Pilzarten. Klinik, Diagnostik und Therapie der Chromomykose werden am Beispiel eines aus Madagaskar stammenden Patienten besprochen. Kulturell konnte bei ihm Cladosporium carrionii Trejos 1954 diagnostiziert werden. Der Pilz zeigte in vitro gute Empfmdlichkeit gegenüber Ketoconazol und wenig bzw. keine Empfmdlichkeit gegen 5‐Flucytosin und Amphotericin B. Ketoconazolbehandlung die noch fortgesetzt wird, führte bei einer Dosis von 400 mg täglich in 4 Monaten ohne Nebenwirkungen zu einer wesentlichen Besserung des Hautbefundes. Summary: Chromomycosis is an infrequently observed, chronic infection, almost exclusively involving the skin. It is caused by certain dark‐coloured moulds. Clinical features of chromomycosis are presented in a patient from Madagaskar with implications on diagnosis and therapy. It was possible to isolate Cladosporium carrionii Trejos 1954. In vitro this fungus was sensitive to Ketoconazole, whereas there was little or no sensitivity to 5‐Flucytosine and Amphotericin B. Treatment with Ketoconazole (400 mg daily) already showed a marked regression of the skin disease in 4 months without any adverse effects of the drug.

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Klinik, Diagnostik mid Therapie der Chromomykose

Mittag¹,

Kreysel²

1982

Mycoses

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Facial Granuloma Associated With Trichosporon cutaneum Infection

Otsuka¹

1986

Arch Dermatol

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A 23-year-old woman presented with Trichosporon cutaneum, which invaded deep into the dermis and subcutaneous tissue of the face and developed chronic granulomatous reactions. We postulated that the local use of an occlusive dressing with topical corticosteroid ointment in the early stage of the infection played a role in promoting the process of this opportunistic fungal infection. Antifungal chemotherapies, selected according to sensitivity testing to the isolated organism, were unsuccessful, mainly because of the acquired resistance of the organism to the chemical agent. Surgery was finally performed and a good result was obtained.

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