Klinik, Diagnostik mid Therapie der Chromomykose

Mittag, H.; Kreysel, H. W.

doi:10.1111/j.1439-0507.1982.tb01958.x

Cited by 5 publications

(1 citation statement)

References 34 publications

(7 reference statements)

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“…Na década de 1980, o cetoconazol que é um derivado az6ico f indicado por diversos autores devido a melhora c1lnica e a menor toxicidad em comparaçao com a anfotericina B, promovidas por esse derivado az6ic no tratamento da micose em questão (MCBURNEY, 1982;MITTAG KREYSEL, 1982). No entanto, em monoterapia ou associado a f1uorocitosina, o uso prolongado de cetoconazol não impediu a ocorrência d recidivas da doença.…”

Section: Culturaunclassified

Avaliação da sensibilidade in vitro de agentes causadores de cromoblastomicose frente a diferentes antifúngicos, isolados e associados

Gimenes¹

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Section: Culturaunclassified

Avaliação da sensibilidade in vitro de agentes causadores de cromoblastomicose frente a diferentes antifúngicos, isolados e associados

Gimenes¹

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In vitro sensitivity of environmental isolates of pathogenic dematiaceous fungi to azole compounds and a phenylpropyl-morpholine derivative

Okeke

Gugnani

1987

Mycopathologia

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The in vitro sensitivity (minimum inhibitory concentrations; MICs) of 42 environmental isolates of pathogenic dematiaceous fungi to 7 azole compounds, viz. thiabendazole, ketoconazole, miconazole, econazole bifonazole, Bay n 7133, Bay 1 9139 and phenylpropyl-morpholine derivative, Ro14-4767/002 was studied by an agar dilution method using Emmon's Sabouraud dextrose agar (ESDA) as the culture medium. The isolates of Fonsecaea pedrosoi, Cladosporium carrionii, Exophiala jeanselmei and Ramichloridium subulatum were most sensitive to bifonazole with mean MICs of 0.06 microgram/ml or less; Phialophora verrucosa had an MIC of 0.05 microgram/ml to ketoconazole and Ro14-4767/002, respectively. Ochroconis sp had an MIC of 0.025 microgram/ml to Ro14-4767/002 and Cladosporium tennuisimum 0.39 microgram/ml to ketoconazole. Econazole and thiabendazole also showed good antifungal activity. The fungi were relatively resistant to the more recently developed azoles, viz. Bay n 7133 and Bay 1 9139, the later failing to inhibit C. tennuisimum at a concentration of 100 micrograms/ml. The minimum fungicidal concentrations (MFC) of the drugs were mostly within 2 to 8 fold of the MICs.

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Chromomykose durch Fonsecaea compacta (Carrion 1940) mit phaeohyphomykotischem Sekundärbefall durch Phaeosclera dematioides (Sigler 1981)/Chromomycosis Caused by Fonsecaea compacta (Carrion 1940) Followed by a Secondary Phaeohyphomycosis Due to Phaeosclera dematioides (Sigler 1981)

Krempl‐Lamprecht¹,

Luderschmidt²,

Wehrmann³

1987

Mycoses

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Zusammenfassung: Wir berichten über einen außergewöhnlichen Chromomykosefall, bei dem neben dem seltenen Erreger Fonsecaea compacta zum ersten Mal am Menschen Phaeosclera dematioides isoliert wurde. Definitionsgemäß handelt es sich demnach urn eine Chromomykose, bei der durch den Schwärzepilz Phaeosclera, der üblicherweise an verholzten Pflanzen auftritt, sekundär eine “phaeohyphomykotische Besiedlung” auftrat. Als klinische Läsion imponierte eine den gesamten Fußrücken überziehende verrucöse Platte, die fan Verlauf von 2–3 Jahrzehnten entstanden war. Histologisch lag die typische pseudoepitheliomatöse Hyperplasie vor; an Pilzelementen wurden fan Corium wenige einzeln liegende dunkle Sclerotialzellen und einige in Gruppen liegende Rundzellen fast ohne Pigmentierung gefunden, nirgends jedoch Hyphen. Zur Therapie wurde Ketoconazol verordnet – 400 mg/Tag –, da befan in‐vitro‐Test beide isolierten Pilze auf diese Substanz am besten ansprachen. Summary: We report on an exceptional chromomycosis whereby in addition to the rare fungus Fonsecaea compacta, Phaeosclera dematioides could be isolated for the first time in a human being. This process can be defined as a case of chromomycosis, where a secondary “phaeohyphomycotic infection” with the fungus Phaeosclera (normally found on ligneous plants) took place. Clinically, a verrucous plate covering the entire back of the foot was observed which had grown to this size over a period of twenty to thirty years. Histologically, a typical pseudoepitheliomateous hyperplasia was seen. Fungal elements were found both in the form of a few dark sclerotial cells, as well as almost pigment‐free round cells. Hyphae could not be found anywhere. The therapy consisted of Ketoconazol (400 mg/day), since both fungi, Fonsecaea and Phaeosclera, were found to be in vitro sensitive to it.

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Klinik, Diagnostik mid Therapie der Chromomykose

Cited by 5 publications

References 34 publications

Avaliação da sensibilidade in vitro de agentes causadores de cromoblastomicose frente a diferentes antifúngicos, isolados e associados

Avaliação da sensibilidade in vitro de agentes causadores de cromoblastomicose frente a diferentes antifúngicos, isolados e associados

In vitro sensitivity of environmental isolates of pathogenic dematiaceous fungi to azole compounds and a phenylpropyl-morpholine derivative

Chromomykose durch Fonsecaea compacta (Carrion 1940) mit phaeohyphomykotischem Sekundärbefall durch Phaeosclera dematioides (Sigler 1981)/Chromomycosis Caused by Fonsecaea compacta (Carrion 1940) Followed by a Secondary Phaeohyphomycosis Due to Phaeosclera dematioides (Sigler 1981)

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